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- ARHL and Tinnitus in Portuguese Population: what we can hear from a sample of elderly individuals.Publication . Flook, M.; Lopes, S.; Aparicio, M.; Santos, R.; Andrade, C.; Andrade, S.; Martins, J.; O'Neill, A.; Escada, P.; Argüello, Patricia; Alcântara, P.; O'Neill, J.; Villaverde Cabral, M.; Antunes, M.; Matos, T.; Fialho, G.; Caria, H.
- Assessing Noncoding Sequence Variants of GJB2 for Hearing Loss Association.Publication . Matos, T. D.; Simões-Teixeira, H.; Caria, Helena; Cascão, R.; Rosa, H.; O'Neill, A.; Dias, O.; Andrea, M.E.; Kelsell, D. P.; Fialho, G.Involvement of GJB2 noncoding regions in hearing loss (HL) has not been extensively investigated. However, three noncoding mutations, c.-259C>T, c.-23G>T, and c.-23+1G>A, were reported. Also, c.-684 -675del, of uncertain pathogenicity, was found upstream of the basal promoter. We performed a detailed analysis of GJB2 noncoding regions in Portuguese HL patients (previously screened for GJB2 coding mutations and the common GJB6 deletions) and in control subjects, by sequencing the basal promoter and flanking upstream region, exon 1, and 3’UTR. All individuals were genotyped for c.-684 -675del and 14 SNPs. Novel variants (c.-731C>T, c.-26G>T, c.∗45G>A, and c.∗985A>T) were found in controls. A hearing individual homozygous for c.-684 - 675del was for the first time identified, supporting the nonpathogenicity of this deletion. Our data indicate linkage disequilibrium (LD) between SNPs rs55704559 (c.∗168A>G) and rs5030700 (c.∗931C>T) and suggest the association of c.[∗168G;∗931T] allele with HL. The c.∗168A>G change, predicted to alter mRNA folding, might be involved in HL.
- Audiological biomarkers of tinnitus in an older Portuguese populationPublication . Haider, Haúla F.; Ribeiro, Diogo; Ribeiro, Sara F.; Trigueiros, Nuno; Caria, Helena; Borrego, Luís; Pinto, Iola; Papoila, Ana L.; Hoare, Derek J.; Paço, JoãoTinnitus is a phantom sound perceived in the absence of external acoustic stimulation. It is described in a variety of ways (e.g., buzzing, ringing, and roaring) and can be a single sound or a combination of different sounds. Our study evaluated associations between audiological parameters and the presence or severity of tinnitus, to improve tinnitus diagnosis, treatment, and prognosis. Our sample included 122 older participants (63 women and 59 men), aged 55–75 years from the Portuguese population, with or without sensory presbycusis and with or without tinnitus. All participants underwent a clinical evaluation through a structured interview, Ear, Nose, and Throat observation, and audiological evaluation (standard and extended audiometry, psychoacoustic tinnitus evaluation, auditory brainstem responses, and distortion product otoacoustic emissions). The Tinnitus Handicap Inventory was used to measure tinnitus symptom severity. Our data confirmed that the odds of developing tinnitus were significantly higher in the presence of noise exposure and hearing loss. Also, participants who had abrupt tinnitus onset and moderate or severe hyperacusis featured higher odds of at least moderate tinnitus. However, it was in the ABR that we obtained the most exciting and promising results, namely, in wave I, which was the common denominator in all findings. The increase in wave I amplitude is a protective factor to the odds of having tinnitus. Concerning the severity of tinnitus, the logistic regression model showed that for each unit of increase in the mean ratio V/I of ABR, the likelihood of having at least moderate tinnitus was 10% higher. Advancing knowledge concerning potential tinnitus audiological biomarkers can be crucial for the adequate diagnosis and treatment of tinnitus.
- Biofísica na Licenciatura em AcupunturaPublication . Letournel, Anna; Caria, Helena
- Bioinformática, uma licenciatura no IPS do século XXI: curso em associaçãoPublication . Gonçalves, António; Santos, Sónia A.P.; Barbosa, Vítor; Caria, Helena
- Biologia marinha: manual de práticas de laboratórioPublication . Climent, Sílvia Rodríguez; Caria, Helena
- Biomarkers of presbycusis and tinnitus in a Portuguese older populationPublication . Haider, Haúla; Flook, Marisa; Ribeiro, Diogo; Antunes, Marília; Szczepek, Agnieszka; Hoare, Derek; Paço, João; Caria, Helena
- Curso de Licenciatura em Acupuntura: a construir o futuro no IPSPublication . Calado, Diogo; Roque, Natália; Pereira, Sara; Seruca, Ana Luísa; Caria, Helena
- Despite reproductive interference, the net outcome of reproductive interactions among spider mite species is not necessarily costlyPublication . Clemente, Salomé; Santos, Inês; Ponce, Rita; Rodrigues, Leonor; Varela, Susana; Magalhães, SaraReproductive interference is considered a strong ecological force, potentially leading to species exclusion. This supposes that the net effect of reproductive interactions is strongly negative for one, or both, of the species involved. Testing this requires a comprehensive analysis of interspecific reproductive interactions, accounting for the order and timing of mating events, and for their effects on either fertility or fecundity. To this aim, we measured reproductive interactions among spider mites, using a focal species, Tetranychus urticae, and an invasive (T. evansi) and a resident (T. ludeni) species, varying the mating sequence and interval, and measuring the effect of such crosses on fecundity and offspring sex ratio (a measure of fertility, as these species are haplodiploid). We found that mating with heterospecifics affected fecundity and sex ratio negatively or positively, depending on the species involved, and on the order and timing of mating events. Overall, the net effect of reproductive interactions was weak despite strong effects of particular events. In natural situations, the outcome of reproductive interactions will thus hinge upon the frequency of each event.