GAT - Grupo de Ativistas em Tratamentos
URI permanente desta comunidade:
O GAT - Grupo de Ativistas em Tratamentos, fundado em 2001, é uma estrutura de adesão individual e de cooperação entre pessoas de diferentes comunidades e de diferentes organizações, afetadas pelo VIH e SIDA, infeções sexualmente transmissíveis, hepatites virais e tuberculose. Trata-se de uma organização não-governamental, sem fins lucrativos registada como IPSS com o nº 11/04 no Livro n 2º das Instituições com Fins de Saúde, e sede em Lisboa.
O repositório do GAT tem como objetivo disponibilizar em Acesso Aberto (AO) toda a produção científica desenvolvida pelos seus associados e trabalhadores com afiliação GAT.
www.gatportugal.org/Navegar
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- Acção & Tratamentos Nº1Publication . Grupo de Ativistas em Tratamentos
- Acceptability of PrEP among HIV negative Portuguese men who have sex with men that attended 2014 Lisbon pride fairPublication . Rocha, Miguel; José Campos, Maria; Brito, João; Fuertes, Ricardo; Rojas, Jesus; Pinto, Nuno; Mendão, Luís; Esteves, Julio
- Acute HIV infection detection: rapid fourth-generation test or rapid molecular point-of-care HIV test?Publication . Rocha, Miguel; Medina, D.; Guerreiro, R.; Correia, H.; Rojas, J.; Ferreira, F.; Verissimo, L.; et al.
- Antimicrobial resistance and molecular characteristics of Neisseria gonorrhoeae isolates from men who have sex with menPublication . Calado, Joana; Castro, Rita; Lopes, Ângela; Campos, Maria José; Rocha, Miguel; Pereira, FilomenaObjectives To analyze the susceptibility of Neisseria gonorrhoeae isolates to penicillin (Pen), cefixime (Cfm), ceftriaxone (Cro), tetracycline (Tet), ciprofloxacin (Cip), azithromycin (Azm), and spectinomycin (Spt), and to verify the presence of mutations in resistance genes. Methods Antibiotic susceptibility testing was performed by Etest method on 30 N. gonorrhoeae isolates collected from the MSM (men who have sex with men) population. PCR and DNA sequencing were performed to identify mutations within the penA, mtrR, gyrA, and parC genes in intermediately resistant and fully resistant isolates. Results N. gonorrhoeae isolates showed intermediate or full resistance to Pen (73%), Cfm (3%), Tet (60%), Cip (37%), and Azm (13%). One isolate with resistance to Cfm presented a penicillin-binding protein 2 (PBP2) mosaic XXXIV. All isolates with intermediate or full resistance to Pen (except at PBP2 mosaic) presented a D345a in PBP2. All Cip-resistant isolates had an S91F in the gyrA gene together with mutations in the parC gene. All intermediate or fully resistant isolates to substrates of the MtrCDE efflux pump had an A39T or G45D mutation in the mtrR gene or an adenine deletion within the mtrR promoter. One isolate presented a Neisseria meningitidis-like mtrR promoter sequence. Conclusions The results of this study are consistent with the findings of other studies and reinforce the importance of the expedient development of new therapeutic options.
- Association of Sexualized Drug Use Patterns with HIV/STI Transmission Risk in an Internet Sample of Men Who Have Sex with Men from Seven European CountriesPublication . Guerras, Juan-Miguel; Hoyos Miller, Juan; Agustí, Cristina; Chanos, Sophocles; Pichon, François; Kuske, Matthias; Cigan, Bojan; Fuertes, Ricardo; Stefanescu, Roxana; Ooms, Lieselot; Casabona, Jordi; de la Fuente, Luis; Belza, María-José; Fernández-Balbuena, S; Maté, T.; Fernández, L.; Platteau, T.; Slaeen, P.; Lixandru, M.; Cosic, M.We estimated the prevalence of overall sexualized drug use (SDU) and of chemsex in particular, assessed patterns of drug use, and identified subpopulations of men who have sex with men (MSM) where SDU and chemsex are more frequent. Using data from an online survey of 9407 MSM recruited during 2016 in 7 European countries, we calculated the proportion of participants who reported SDU and chemsex (mephedrone, methamphetamine, and/or GHB/GBL) in the last 12 months. We grouped the different drug-use combinations in patterns and described sexual risk behaviors, sexually transmitted infections (STI), and HIV seropositivity for each one of them. Factors associated with SDU and chemsex were assessed with two logistic regression models. SDU was reported by 17.7% and chemsex by 5.2%. Risk indicators increased through the different SDU patterns but were higher within those including chemsex drugs. In the multivariate analysis, chemsex was independently associated with living in Slovenia. Both SDU and chemsex were independently associated with living in Spain; being < 50 years old; living in cities of > 500,000 inhabitants; being open about their sex life; reporting transactional sex; condomless anal intercourse; having received an STI diagnosis and with being HIV positive or having been tested ≤ 12 months ago. Magnitude of associations was higher in the chemsex model. One in five participants reported SDU, but prevalence of chemsex was notably lower. However, the risk profiles and higher prevalence of HIV/STIs among those involved in chemsex suggest the existence of a subpopulation of MSM that could be playing a relevant role in the HIV and STI epidemics, especially in very large cities of some countries.
- Bias-Motivated Physical or Verbal Violence Among Men Who Have Sex with Men: Findings from the Lisbon Cohort of MSMPublication . Vieira, Laís; Fraga, Sílvia; Rocha, Miguel; Oliveira, Miguel; Meireles, Paula
- Chlamydia trachomatis: when the virulence-associated genome backbone imports a prevalence-associated major antigen signaturePublication . Borges, Vítor; Cordeiro, Dora; Salas, Ana Isabel; Lodhia, Zohra; Correia, Cristina; Isidro, Joana; Fernandes, Cândida; Rodrigues, Ana Maria; Azevedo, Jacinta; Alves, João; Roxo, João; Rocha, Miguel; Côrte-Real, Rita; Vieira, Luís; Borrego, Maria José; Gomes, João PauloChlamydia trachomatis is the most prevalent sexually transmitted bacterium worldwide and the causative agent of trachoma. Its strains are classified according to their ompA genotypes, which are strongly linked to differential tissue tropism and disease outcomes [ocular disease, urogenital disease and lymphogranuloma venereum (LGV)]. While the genome-based species phylogenetic tree presents four main clades correlating with tropism/prevalence, namely ocular, LGV, urogenital T1 (more prevalent genotypes) and urogenital T2 (less prevalent genotypes), inter-clade exchange of ompA is considered a rare phenomenon probably mediating marked tropism alterations. An LGV epidemic, associated with the clonal expansion of the L2b genotype, has emerged in the last few decades, raising concerns particularly due to its atypical clinical presentation (ulcerative proctitis) and circulation among men who have sex with men (MSM). Here, we report an LGV outbreak, mostly affecting human immunodeficiency virus-positive MSM engaging in high-risk sexual practices, caused by an L2b strain with a rather unique non-LGV ompA signature that precluded the laboratory notification of this outbreak as LGV. C. trachomatis whole-genome capture and sequencing directly from clinical samples was applied to deeply characterize the genomic backbone of this novel LGV outbreak-causing clone. It revealed a chimeric genome structure due to the genetic transfer of ompA and four neighbouring genes from a serovar D/Da strain, likely possessing the genomic backbone associated with the more prevalent urogenital genotypes (T1 clade), to an LGV (L2b) strain. The hybrid L2b/D-Da strain presents the adhesin and immunodominant antigen MOMP (major outer membrane protein) (encoded by ompA) with an epitope repertoire typical of non-invasive genital strains, while keeping the genome-dispersed virulence fingerprint of a classical LGV strain. As previously reported for inter-clade ompA exchange among non-LGV clades, this novel C. trachomatis genomic mosaic involving a contemporary epidemiologically and clinically relevant LGV strain may have implications on its transmission, tissue tropism and pathogenic capabilities. The emergence of variants with epidemic and pathogenic potential highlights the need for more focused surveillance strategies to capture C. trachomatis evolution in action.
- City-level drug policies in Portugal: the COVID-19 pandemic as an analyzer of harm reduction responsiveness in Porto and Lisbon.Publication . Vale Pires, Cristiana; Cunha Curado, Adriana; Fuertes, Ricardo; Carvalho, Maria Carmo; Valente, HelenaThe COVID-19 pandemic health crisis and its potential implications for people who use drugs (PWUD) created permissive conditions toward social innovation and experimentation. Still, it also exposed gaps in harm reduction approaches. Harm reduction responsiveness was informed by the priorities defined at the local level, so it was not applied uniformly in different regions. This paper intends to contribute to the analysis of harm reduction responsiveness during the COVID-19 outbreak by comparing the adaptations and implementation of harm reduction and municipal services to support street-involved (SI) PWUD in two Portuguese cities- Porto and Lisbon. This study aims to shed light on the city-level implementation of drug policies in Portugal.
- CIVIL SOCIETY SURVEY: GOOD PRACTICES IN PRISON SETTINGSPublication . Civil Society Forum on Drugs EU
- Co-creating a Mpox Elimination Campaign in the WHO European Region: The Central Role of Affected CommunitiesPublication . Palumbo, Leonardo; Picchio, Camila A; Barbier, Franck; Calderon-Cifuentes, Amanita; James, Jules; Lunchenkov, Nikolay; Nutland, Will; Owen, Greg; Orkin, Chloe; Rocha, Miguel; Shanley, Adam; Stevenson, Luca; Vinti, Pietro; Salvi, Cristiana