Percorrer por autor "Viegas, Susana"
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- Current advances, research needs and gaps in mycotoxins biomonitoring under the HBM4EU : lessons learned and future trendsPublication . Alvito, Paula; Assunção, Ricardo; Bajard, Lola; Martins, Carla; Mengelers, Marcel J. B.; Mol, Hans; Namorado, Sónia; van den Brand, Annick D.; Vasco, Elsa; Viegas, Susana; Silva, Maria JoãoMycotoxins are natural metabolites produced by fungi that contaminate food and feed worldwide. They can pose a threat to human and animal health, mainly causing chronic effects, e.g., immunotoxic and carcinogenic. Due to climate change, an increase in European population exposure to mycotoxins is expected to occur, raising public health concerns. This urges us to assess the current human exposure to mycotoxins in Europe to allow monitoring exposure and prevent future health impacts. The mycotoxins deoxynivalenol (DON) and fumonisin B1 (FB1) were considered as priority substances to be studied within the European Human Biomonitoring Initiative (HBM4EU) to generate knowledge on internal exposure and their potential health impacts. Several policy questions were addressed concerning hazard characterization, exposure and risk assessment. The present article presents the current advances attained under the HBM4EU, research needs and gaps. Overall, the knowledge on the European population risk from exposure to DON was improved by using new harmonised data and a newly derived reference value. In addition, mechanistic information on FB1 was, for the first time, organized into an adverse outcome pathway for a congenital anomaly. It is expected that this knowledge will support policy making and contribute to driving new Human Biomonitoring (HBM) studies on mycotoxin exposure in Europe.
- Editorial : human biomonitoring (HBM) as a tool to support policy and regulatory action to prevent chemicals exposurePublication . Viegas, Susana; Martins, Carla; Assunção, Ricardo
- Exposure assessment of the European adult population to deoxynivalenol – results from the HBM4EU Aligned StudiesPublication . Namorado, Sónia; Martins, Carla; Ogura, Joana; Assunção, Ricardo; Vasco, Elsa; Appenzeller, Brice; Halldorsson, Thorhallur I.; Janasik, Beata; Kolossa-Gehring, Marike; Nieuwenhuyse, An Van; Ólafsdóttir, Kristin; Rambaud, Loïc; Riou, Margaux; Silva, Susana; Wasowicz, Wojciech; Weber, Till; Esteban-López, Marta; Castaño, Argelia; Gilles, Liese; Martin, Laura Rodríguez; Govarts, Eva; Schoeters, Greet; Viegas, Susana; Silva, Maria João; Alvito, PaulaMycotoxins are natural toxins produced by fungi that may cause adverse health effects thus constituting a public health concern. Deoxynivalenol (DON), a mycotoxin affecting the immune system and causing intestinal disorders, was selected as a priority under the European Human Biomonitoring Initiative (HBM4EU). Urinary total DON levels (tDON) of 1270 participants from six countries were used to characterize the internal exposure of the adult European population and identify the most relevant determinants of exposure. tDON concentrations’ P50 and P95 were in the range of 0.41–10.16 µg/L (0.39–9.05 µg/g crt) and 3.25–46.58 µg/L (2.12–33.50 µg/g crt) respectively. Higher tDON levels were observed for (i) male participants from France and Germany, (ii) samples collected in spring and summer, (iii) participants with a lower educational level, (iv) participants living in rural areas, (v) individuals without a job in France and Luxembourg, while in Portugal higher exposure was observed in working individuals, (vi) individuals with higher consumption of cereals and bread. The proportion of individuals with exposure levels exceeding the HBM-GV of 23 µg/L was 12.3 %, ranging from 0.8 % to 20.7 % in the individual countries. This study on mycotoxins exposure has used post harmonized questionnaire data and validated analytical methodologies for analysis and covered countries representing the four geographical regions of Europe, having produced much needed knowledge on the exposure of the European adult population to deoxynivalenol.
- Health burden and costs attributable to the carbon footprint of the health sector in the European UnionPublication . Chen-Xu, José; Corda, Mariana O.; Varga, Orsolya; Viegas, SusanaBackground: The healthcare sector has an environmental impact of around 4.6% of global CO2 emissions, contributing to aggravating the climate crisis. However, the impact of the health sector’s emissions on human health is not regularly assessed. We aim to estimate the health burden and associated costs of the health sector’s carbon footprint within the European Union (EU). Methods: We calculated disability-adjusted life years (DALYs) and associated costs based on human health damage factors (DALYs/kg-CO2e) by considering four scenarios. Three scenarios for shared socioeconomic pathways (S1 – high growth, S2 − baseline, and S3 − low growth) represented variations of global society, demographics, and economics until 2100. A fourth scenario (S4) considered the current EU’s 55% reduction goal of greenhouse gas emissions. The healthcare sector’s emissions per capita (in CO2-equivalent) in 2019 were extracted from the Lancet Countdown, and population data were retrieved from Eurostat for the same year. Results: In the EU, 365,047 DALYs (95%CI: 194,692–535,403) are expected to be caused by the health sector’s emissions at baseline (S2). In an S1 scenario, the burden would slightly decrease to 316,374 DALYs (95%CI: 170,355–462,393), whereas a S3 scenario would increase 486,730 DALYs (95%CI: 243,365–681,422). If EU’s carbon goals are met, the burden could be substantially reduced to 164,271 DALYs (95%CI: 87,611–240,931). Costs can amount to 25.6 billion euros, when considering DALYs monetisation. Conclusion: CO2 emissions from the health sector are expected to significantly impact human health. Therefore, it is important to ensure that EU climate policies for public buildings are in line with the Paris Agreement, increase funding for climate mitigation programs within the healthcare sector, and review clinical practices at the local level.
- Training on the impact of climate change on public health : reflections and lessons learntPublication . Viegas, Susana; Santos, João Almeida; Kazmierczak, Aleksandra; Assunção, Ricardo; Viegas, Carla; Martins, Carla
- Vitamin D levels in Portuguese Navy military personnelPublication . Henriques, Santos; Serranheira, Florentino; Viegas, Susana; Sacadura-Leite, Ema; BMJ Group