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- Potential herb–drug interactions in the management of age-related cognitive dysfunctionPublication . Auxtero, Maria Deolinda; Chalante, Susana; Abade, Mário R.; Jorge, Rui; Fernandes, A.I.
- Polyvinyl alcohol/chitosan wound dressings loaded with antisepticsPublication . Massarelli, E.; Silva, D.; Pimenta, A. F. R.; Fernandes, A.I.; Mata, J. L. G.; Armês, H.; Salema-Oom, Madalena; Saramago, B.; Serro, A.P.Wound care remains a challenge in healthcare. This work aimed to develop a new polyvinyl alcohol (PVA)/chitosan (Ch) based wound dressing able to ensure protection, hydration and a controlled release of antiseptics, as alternative to actual treatments. Two distinct formulations (1:1 and 3:1, w/w) were prepared, sterilized by autoclaving and characterized concerning surface morphology, degradation over the time, mechanical properties and hydrophilicity. Both dressings revealed adequate properties for the intended purpose. The dressings were loaded with chlorhexidine (CHX) and polyhexanide (PHMB) and the drug release profiles were determined using Franz diffusion cells. The release of PHMB was more sustained than CHX, lasting for 2 days. As the amounts of drugs released by PVA/Ch 1:1 were greater, the biological tests were done only with this formulation. The drug loaded dressings revealed antibacterial activity against S. aureus and S. epidermidis, but only the ones loaded with PHMB showed adequate properties in terms of cytotoxicity and irritability. The application of this elastic dressing in the treatment of wounds in a dog led to faster recovery than conventional treatment, suggesting that the material can be a promising alternative in wound care.
- Performance and paroxetine stability in tablets manufactured by fused deposition modelling-based 3D printingPublication . Figueiredo, Sara; Fernandes, A.I.; Carvalho, Fátima G.; Pinto, João F.Objectives: The objective of this study was to develop a method for the preparation and characterization of paroxetine (PRX) tablets, obtained by coupling hot-melt extrusion and fused deposition modelling (FDM)-based three-dimensional printing (3DP) technology. The impact of the printing process parameters on the drug stability and on the tablets performance was assessed.
- Solid state conversion of olanzapine during tabletingPublication . Costa, Nuno F. da; Fernandes, A.I.; Daniels, Rolf; Pinto, João F.
- Production of individualized medicines by additive manufacture (3D-printing)Publication . Figueiredo, Sara; Carvalho, Fátima; Fernandes, A.I.; Pinto, João F.
- 3D-Printing of paracetamol tablets by fused deposition modellingPublication . Pereira, Gabriela G.; Henriques, Ana I.; Fernandes, A.I.; Santos, Inês A.; Pinto, João F.
- Downstream processing of co-amorphous olanzapinePublication . Costa, Nuno F. da; Fernandes, A.I.; Pinto, João F.
- Production of individualized medicines by additive manufacture (3D-printing)Publication . Figueiredo, Sara; Carvalho, Fátima; Fernandes, A.I.; Pinto, João F.
- Downstream processing of co-amorphous olanzapinePublication . Costa, Nuno F. da; Fernandes, A.I.; Pinto, João F.
- 3D-Printing of paracetamol tablets by fused deposition modellingPublication . Pereira, Gabriela G.; Henriques, Ana I.; Fernandes, A.I.; Santos, Inês A.; Pinto, João F.