Browsing by Author "Pereira, Joana"
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- Caracterização dos pais e perceção dos mesmos sobre aulas de natação para bebésPublication . Encarnação, Ana; Mendes, Patrícia; Miranda, Sílvia; Gouveia, Carina; Pereira, Joana; Marques, Liliana; Nunes, Paulo; Figueiredo, Teresa; Figueira, Ana; Pereira, A; Ferreira, Cátia; Espada, MárioO objetivo do presente estudo foi aferir o perfil dos pais e perceção destes relativamente às aulas de natação para bebés. Quarenta e cinco pais de crianças integradas em aulas de natação para bebés em três piscinas do Distrito de Setúbal preencheram oquestionário. 82.2% dos educadores transmitiram ter mantido o hábito de prática desportiva no passado, ao passo que apenas 51.5% indicou manter a prática no momento do estudo. A totalidade dos pais considerou relevante a emissão de feedbackpor parte dos professores de natação para bebés nas aulas e o conhecimento das metodologias aplicadas nas aulas. É fundamental caracterizar os responsáveis pelo envolvimento de bebés em aulas de natação e compreender as suas ideias sobre a natação para bebés no sentido de procurar ser adaptada a oferta à procura da atividade em amplo crescimento.
- O Ciberespaço e a mutação da realidade: o caso dos EUAPublication . Pereira, Joana
- A classificação da Universidade, Alta e Sofia como património mundial da Unesco : uma reflexão sobre a divulgação de um destino turístico classificadoPublication . Pereira, Joana; Moura, AndreiaA grandeza e notoriedade da Universidade de Coimbra, bem como a classificação atribuída pela UNESCO, que a coloca junto do Património da Humanidade veio reforçar a sua importância e o seu interesse em termos de estudo científico no âmbito do turismo. Desta forma, verificou-se pertinente compreender o potencial trazido pela classificação UNESCO para o destino turístico de Coimbra e perceber de que forma as entidades turísticas locais assimilaram esta nova realidade em termos de divulgação do destino. Assim, em termos metodológicos procedeu-se à realização de um estudo exploratório de natureza qualitativa, através da realização de entrevistas às entidades turísticas locais, devidamente selecionadas de acordo com a sua pertinência e relação com a temática em estudo. Os resultados dão conta que a imagem do destino turístico de Coimbra é indissociável da própria Universidade e que o número de turistas aumentou após a sua classificação como património da Humanidade, apurando-se que a divulgação deste património e da sua chancela não é, de todo, eficiente.
- Comparação entre composição corporal e aptidão física em ginastas femininas de trampolins e acrobáticaPublication . Pereira, Joana; Vasques, Ana; Marques, Liliana; Nunes, Paulo; Pereira, A; Espada, Mário; Figueiredo, Teresa
- Is there a C-reactive protein value beyond which one should consider infection as the cause of acute heart failure?Publication . Pereira, Joana; Ribeiro, Ana; Ferreira-Coimbra, Joao; Barroso, Isaac; Guimaraes, Joao-Tiago; Bettencourt, Paulo; Lourenco, PatriciaBACKGROUND: Heart Failure (HF) is a low grade inflammatory condition. High sensitivity C-reactive protein (hsCRP) is an established marker of inflammation. A cut-off value of hsCRP beyond which an infection should be sought has never been studied in HF. We aimed to determine the best hsCRP cut-off for infection prediction in acute HF. METHODS: We analyzed patients included in an acute HF registry - EDIFICA (Estratificação de Doentes com InsuFIciência Cardíaca Aguda). Admission hsCRP measurement was available as part of the registry's protocol. Patients with acute coronary syndrome as the cause of acute HF were excluded from the registry. Infection was considered according to the diagnosis registered in the discharge record. A receiver-operating characteristic (ROC) curve was used to determine the best hsCRP cut-off for infection prediction. RESULTS: We studied 615 patients. Mean age was 76 years, 45.2% were male, 60.3% had systolic dysfunction. Median admission hsCRP was 20.3 (9.5-55.5)mg/L; in 41.6% the cause of decompensation was an infection. The area under the ROC curve for admission hsCRP in the prediction of infection was 0.79 (0.76-0.83); the best hsCRP cut-off was 25 mg/L with a sensitivity of 72.7%, specificity 77.2%, positive predictive value 69.4% and negative predictive value 79.9%. Age and elevated hsCRP independently associated with an infection as the precipitant of acute HF. CONCLUSIONS: We suggest 25 mg/L as a cut-off beyond which an infection should be sought underlying acute HF. Almost 80% of the patients with hsCRP< 25 mg/L are not infected and 69.4% of those with higher hsCRP have a concomitant infection.
- Superior Mesenteric Artery Syndrome: A Rare Cause of Intestinal ObstructionPublication . Ribeiro, Andreia; Pereira, Joana; Tonel, Carla
- Trajetórias Relacionais e Reprodutivas Conducentes à Gravidez na Adolescência: a Realidade Nacional e Regional PortuguesaPublication . Pires, Raquel; Pereira, Joana; Pedrosa, Anabela Araújo; Bombas, Teresa; Vilar, Duarte; Vicente, Lisa; Canavarro, Maria CristinaIntroduction: The current study aimed to describe the relational and reproductive trajectories leading to adolescent pregnancy in Portugal, and to explore whether there were differences in this process according to adolescents’ place of residence. Material and Methods: Data were collected between 2008 and 2013 in 42 public health services using a self-report questionnaire developed by the researchers. The sample consisted of a nationally representative group of pregnant adolescents (n = 459). Results: Regardless of having had one (59.91%) or multiple sexual partners (40.09%), the majority of adolescents became pregnant in a romantic relationship, using contraception at the time of the conception and knowing the contraceptive failure which led to pregnancy (39.22%). In some regions other trajectories were highly prevalent, reflecting options such as planning the pregnancy (Alentejo Region/Azores Islands), not using contraception (Centro Region/Madeira Islands) or using it incorrectly, without identifying the contraceptive failure (Madeira Islands). On average, romantic relationships were longer than 19 months and adolescents’ partners were older than themselves (> 4 years) and no longer in school (75.16%); these results were particularly significant when the pregnancy was planned. Discussion: The knowledge gained in this study shows that prevention efforts must be targeted according to the adolescents’ needs in each region and should include high-risk male groups. Conclusion: Our results may enable more efficient health policies to prevent adolescent pregnancy in different country regions and support educators and health care providers on sexual education and family planning efforts.
- UHPLC-MS/MS methodology for analysis of new synthetic opioids and hallucinogens in whole bloodPublication . Pereira, Joana; Antunes, Mónica; Neng, N.R.; Mustra, Carla; Franco, João; Fonseca, SuzanaBackground & Aims: New Psychoactive Substances (NPS) are a real contemporaneous threat, due to their potency, dangerousness, and lack of control/monitoring. The NPS group that has grown the most is the synthetic opioids group, where fentanyl and its analogues stand out. However, the emerging concerning synthetic opioids are nitazenes. Due to their high potency, even minimal consumption doses can lead to severe health effects or even fatal overdoses, making them a public health issue. Notwithstanding, is it also important to remain vigilant towards more “traditional” psychoactive substances like hallucinogens once they have been associated with both intentional and unintentional poisonings/intoxications. This is particularly relevant now that they are also being used for clinical purposes. Therefore, it is essential to establish analytical methodologies for monitoring these compounds. As a result, the aim of this study was to develop, optimize and validate an easy to use, fast, simple, sensitive, robust, and routine flow method for the analysis of new synthetic opioids (fentanyls and nitazenes) and (classic) hallucinogens in whole blood. Methods: The present work describes a method that allows the screening, qualitative confirmation, and quantification of more than 10 psychoactive substances, including new synthetic opioids and hallucinogens. The sample preparation step consisted in 50 µL of whole blood protein precipitation with refrigerated acetonitrile containing formic acid and was optimized using a design of experiments (DoE) approach, namely Full Factorial Design, to achieve the best conditions for compounds extraction from matrix. Following centrifugation, the resulting supernatant extract can be directly injected into an ultra-high-performance liquid chromatograph coupled to a triple quadrupole linear ion trap mass spectrometer (Sciex UHPLC-QTRAP-MS® 6500+) and analyzed in a 5-minute run in Multiple Reaction Monitoring (MRM) mode with 2 transitions for each compound. The developed analytical methodology was fully validated according to the guiding principles of the ANSI/ASB Standard 036. To confirm its applicability in a real context, the proposed methodology was applied to the analysis of authentic forensic samples. Results & Discussion: In terms of validation, the methodology linearity was assessed between 1 and 20 ng/mL. The precision and accuracy were satisfactory, with values <15% and within ±15% (20% at the LOQ), respectively. The limits of detection were between 0.1 and 1 ng/mL, depending on the compound. Dilution ratios were also successfully evaluated. Selectivity was confirmed by analyzing spiked samples containing several therapeutic drugs and other drugs of abuse. Conclusion: The proposed methodology provides a valuable and powerful tool for toxicology laboratory, enabling the simultaneous identification, confirmation, and quantification of different families of psychoactive substances, including synthetic opioids and hallucinogens. Its speed, simplicity, effectiveness, and reliability make it particularly advantageous for routine analysis. These combined advantages make it a suitable alternative for routine implementation.