Browsing by Author "Caria, Helena"
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- Age-related hearing loss: is this a preventable condition?Publication . Aparício, M.; Matos, T. M.; Arguello, Patricia; Antunes, M.; O'Neill, A.; Escada, P.; Caria, Helena
- Age4all: uma sinergia científica no IPSPublication . Leotournel, Anna; Germano, Helena; Gronita, Joaquim; Nunes, Nuno; Arguello, Patricia; Gomes, Ana; Teles, Edgar; Dias, Inês; Brito, Maeva; Gonçalves, Tânia; Caria, Helena
- Aprendizagem com base em processos de cocriação: o exemplo do DEMOLA® no Instituto Politécnico de SetúbalPublication . Silva, Maria Alcina Velho Dourado da; Ruivo, Maria Alice Gois; Ramos, Bernardo; PICOITO, CÉLIA; Serralha, F. N.; Angelino, F J A; Caria, Helena; Vinagre, João; Pires, José; Pereira, NunoAssistimos, atualmente a inúmeras parcerias e projetos de âmbito nacional e internacional na área da formação ativa, com recurso à utilização de ferramentas digitais e assentes em processos de cocriação entre diferentes parceiros, com o objetivo de se obterem processos/percursos mais criativos e adequados, que respondam de forma eficaz aos desafios científicos que vivemos e se avizinham. Neste artigo procede-se à apresentação, de forma sumária, da participação de um grupo de docentes do Instituto Politécnico de Setúbal no Projeto DEMOLA®. Apresentamos os objetivos, a constituição das equipas e a metodologia de trabalho estabelecida. Descrevemos as principais fases que constituem o desenvolvimento do projeto no âmbito do IPS e os resultados que obtivemos da análise de todas componentes (formação estudantes, docentes, desafios com as empresas/ organizações e perceções de toda a equipa). Salientam-se o desenvolvimento de competências instrumentais (Canva, Miro, PESTLE, Portefólio); competências científicas/pedagógicas (Trabalho em Equipa, Abordagem Multiprofissional, Processos de Cocriação, Design Thinking, Pesquisa, Facilitação, Pensamento Disruptivo e Coconstrução, entre outros); e situações de “win-win”, ou melhor “learn-learn” entre facilitadores e estudantes, inovação, intergerações, sustentabilidade e liberdade de pensamento.
- Assessing Noncoding Sequence Variants of GJB2 for Hearing Loss Association.Publication . Matos, T. D.; Simões-Teixeira, H.; Caria, Helena; Cascão, R.; Rosa, H.; O'Neill, A.; Dias, O.; Andrea, M.E.; Kelsell, D. P.; Fialho, G.Involvement of GJB2 noncoding regions in hearing loss (HL) has not been extensively investigated. However, three noncoding mutations, c.-259C>T, c.-23G>T, and c.-23+1G>A, were reported. Also, c.-684 -675del, of uncertain pathogenicity, was found upstream of the basal promoter. We performed a detailed analysis of GJB2 noncoding regions in Portuguese HL patients (previously screened for GJB2 coding mutations and the common GJB6 deletions) and in control subjects, by sequencing the basal promoter and flanking upstream region, exon 1, and 3’UTR. All individuals were genotyped for c.-684 -675del and 14 SNPs. Novel variants (c.-731C>T, c.-26G>T, c.∗45G>A, and c.∗985A>T) were found in controls. A hearing individual homozygous for c.-684 - 675del was for the first time identified, supporting the nonpathogenicity of this deletion. Our data indicate linkage disequilibrium (LD) between SNPs rs55704559 (c.∗168A>G) and rs5030700 (c.∗931C>T) and suggest the association of c.[∗168G;∗931T] allele with HL. The c.∗168A>G change, predicted to alter mRNA folding, might be involved in HL.
- Audiological biomarkers of tinnitus in an older Portuguese populationPublication . Haider, Haúla F.; Ribeiro, Diogo; Ribeiro, Sara F.; Trigueiros, Nuno; Caria, Helena; Borrego, Luís; Pinto, Iola; Papoila, Ana L.; Hoare, Derek J.; Paço, JoãoTinnitus is a phantom sound perceived in the absence of external acoustic stimulation. It is described in a variety of ways (e.g., buzzing, ringing, and roaring) and can be a single sound or a combination of different sounds. Our study evaluated associations between audiological parameters and the presence or severity of tinnitus, to improve tinnitus diagnosis, treatment, and prognosis. Our sample included 122 older participants (63 women and 59 men), aged 55–75 years from the Portuguese population, with or without sensory presbycusis and with or without tinnitus. All participants underwent a clinical evaluation through a structured interview, Ear, Nose, and Throat observation, and audiological evaluation (standard and extended audiometry, psychoacoustic tinnitus evaluation, auditory brainstem responses, and distortion product otoacoustic emissions). The Tinnitus Handicap Inventory was used to measure tinnitus symptom severity. Our data confirmed that the odds of developing tinnitus were significantly higher in the presence of noise exposure and hearing loss. Also, participants who had abrupt tinnitus onset and moderate or severe hyperacusis featured higher odds of at least moderate tinnitus. However, it was in the ABR that we obtained the most exciting and promising results, namely, in wave I, which was the common denominator in all findings. The increase in wave I amplitude is a protective factor to the odds of having tinnitus. Concerning the severity of tinnitus, the logistic regression model showed that for each unit of increase in the mean ratio V/I of ABR, the likelihood of having at least moderate tinnitus was 10% higher. Advancing knowledge concerning potential tinnitus audiological biomarkers can be crucial for the adequate diagnosis and treatment of tinnitus.
- Biofísica na Licenciatura em AcupunturaPublication . Letournel, Anna; Caria, Helena
- Bioinformática, uma licenciatura no IPS do século XXI: curso em associaçãoPublication . Gonçalves, António; Santos, Sónia A.P.; Barbosa, Vítor; Caria, Helena
- Biologia marinha: manual de práticas de laboratórioPublication . Climent, Sílvia Rodríguez; Caria, Helena
- Biomarkers of presbycusis and tinnitus in a Portuguese older populationPublication . Haider, Haúla; Flook, Marisa; Ribeiro, Diogo; Antunes, Marília; Szczepek, Agnieszka; Hoare, Derek; Paço, João; Caria, Helena
- Co-creation design thinking process: learning with Demola approachPublication . PICOITO, CÉLIA; Caria, Helena; Angelino, F J A; Velho Dourado Da Silva, Maria Alcina; Pereira, Nuno; Serralha, F. N.; Ruivo, Maria Alice Gois; Vinagre, João; Pires, José