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Integrated Reporting
Publication . Agra, Carlos André Louro; Reis, Ricardo Ferreira; Dias, André Ferreira
A presente dissertação debruça-se sobre a aplicação do Integrated Reporting (IR) para mapear a criação de valor na Marinha Portuguesa. Num cenário global de crescente procura por transparência e otimização de recursos, a Marinha Portuguesa, embora com a sua missão central de defesa e segurança nacional, gera valor em múltiplas dimensões que vão além do estritamente militar, contribuindo para o bem-estar e segurança da nação. O IR emerge como uma ferramenta inovadora para comunicar esta história completa de criação de valor a longo prazo, conectando atividades, desempenho, desafios e perspetivas futuras aos seus diversos capitais: financeiro, manufaturado, intelectual, humano, social e de relacionamento, e natural. O estudo salienta que o IR, concebido inicialmente para o setor privado, tem potencial imenso no setor público e militar. Contudo, representa um desafio metodológico e prático significativo traduzir a doutrina militar e as operações diárias, que muitas vezes envolvem confidencialidade, hierarquias rígidas e uma lógica de comando e controlo, num modelo de criação de valor abrangente e transparente para múltiplos stakeholders, civis e militares. A investigação procura preencher essa lacuna no conhecimento existente sobre a aplicação do IR em contextos não empresariais e de segurança. Através da análise dos seis capitais do framework do IR, o estudo oferece insights valiosos que podem fortalecer a legitimidade social da Marinha Portuguesa, otimizar a gestão de recursos e melhorar a comunicação do seu papel vital e do valor gerado aos cidadãos e ao governo. O objetivo central de investigação (OCI) é mapear a criação de valor da Marinha Portuguesa através do framework. A abordagem visa aprofundar a compreensão sobre como os diversos capitais podem ser identificados, geridos e comunicados em organizações onde o lucro financeiro não é o principal motor, mas sim o impacto social e a defesa nacional. Integrated Reporting; Marinha Portuguesa; Framework; Capitais; Defesa Nacional
Improving properties of an experimental universal adhesive by adding a multifunctional dendrimer (G-IEMA) : bond strength and nanoleakage evaluation
Publication . Cruz, Joana Vasconcelos e; Delgado, António H. S.; Félix, Samuel; Brito, José; Gonçalves, Luísa; Polido, Mário
A vast number of adhesive formulations exist currently. However, available adhesives still have several drawbacks such as increased hydrophilicity, polymerization deficiency, potential cytotoxicity and limited monomer interdiffusion within dentin. To improve material properties, a Bisphenol A-free adhesive containing a novel dendrimer G(2)-isocyanatoethyl methacrylate (G-IEMA) in replacement of Bis-GMA was made and tested. Sound human molars were sectioned to expose mid-coronal dentin, which was bonded using four adhesives—Futurabond, Scotchbond Universal and experimentals EM1 and EM2. The experimental adhesive EM2 contained G-IEMA, while EM1 had Bis-GMA. Groups were further allocated to two different adhesive strategies: etch-and-rinse (20 s etching) or self-etch. Immediate (24 h) microtensile bond strength to dentin (n = 5) was tested using a universal testing machine (1 mm/min, 5 kN; Shimadzu AGS-X Autograph, Tokyo, Japan), while the ultrastructure of the interface (n = 2) was assessed using scanning electron microscopy-energy dispersive spectroscopy (SEM-EDS). Nanoleakage expression was evaluated using silver nitrate penetration and posterior SEM-EDS analysis (n = 3). Linear mixed models/Generalized models were used for inferential statistics (5% significance level). Bond strength results did not depend on the adhesive choice, although differences were found between strategies (p < 0.001). Regarding nanoleakage, when applied in an etch-and-rinse mode, experimental adhesives scored lower nanoleakage means than Futurabond and Scotchbond Universal. The novel adhesive shows interesting interfacial properties, with favorable nanoleakage results and a bond strength to dentin that matches current commercial adhesives.
Impact of mechanical complications on success of dental implant treatments : a case–control study
Publication . Ferreira, Patrícia W.; Nogueira, Paulo J.; Nobre, Miguel A. de Araújo; Guedes, Carlos Moura; Salvado, Francisco
Objective: This study aimed to investigate the impact of mechanical complications on outcome measures for implant dentistry.
Materials and methods: This case-control study included 282 patients with mechanical complications occurring in fixed prosthetic rehabilitation supported by immediate function implants with external connection (cases) and 282 individuals without mechanical complications (control). Pairing was performed for sex, age (range = 3 years), and follow-up months (range = 11 months). The primary outcome measure was implant survival, while the secondary outcome measures were marginal bone loss and biological complication parameters (peri-implant pathology, soft tissue inflammation, fistula formation, and abscess formation).
Statistical analysis: Cumulative implant survival was estimated by using life tables. Descriptive statistics with 95% confidence intervals (CI) and inferential statistics (Chi-square test) were performed to evaluate differences between cases and controls. The significance level was set at 5%.
Results: The average follow-up duration was 8.5 years. Mechanical complications included prosthetic fracture (n = 159), abutment loosening (n = 89), prosthetic screw loosening (n = 20), milled abutment (n = 12), milled prosthetic screw (n = 1), and decemented crown (n = 1). Implant failure occurred in one patient from the control group, with survival rates of 100 and 99.6% for cases and controls, respectively (p = 0.317). The average marginal bone loss was 1.72 (95% confidence interval [CI]: 1.60-1.84) for cases and 1.55 (95% CI: 1.45-1.65) for controls (p = 0.068). Biological complications were observed in 90 patients, with significant differences between cases (n = 54) and controls (n = 36; p = 0.038).
Conclusion: Mechanical complications did not significantly influence survival or marginal bone loss; nevertheless, there is a need for studies with longer follow-up duration. Mechanical complications also significantly influence the incidence of biological complications.
Alargamento do complexo arqueológico de Conimbriga. Trabalhos arqueológicos no setor F
Publication . Correia, Virgílio Hipólito; Perpétuo, João
Relatório final do projeto MUBICOF (MUralha do Baixo-Império de Conimbriga, setor F).
Impact of body composition on prognosis and dose-limiting toxicities on metastatic colorectal cancer
Publication . Dias, David da Silva; Machado, Mafalda; Trabulo, Carolina; Gosálbez, Beatriz; Ravasco, Paula
Sarcopenia is a progressive skeletal muscle disease, often present in oncological patients, that is associated with multiple adverse events such as worse prognosis, physical performance, and quality of life. Body composition evaluation by CT cross-section at the L3 vertebrae region appears to be a precise method to quantify skeletal muscle. The optimal cut-off for the definition of sarcopenia is not yet established, therefore the incidence of sarcopenia varies according to different studies. The main goal was to evaluate the presence of sarcopenia in patients with metastatic colorectal cancer (mCRC) and its impact on overall survival (OS) and dose-limiting toxicities (DLT). A retrospective cohort study of 178 patients with mCRC under first-line chemotherapy (ChT) in association with target therapy, in two hospital units, between January 2015 and December 2018. Skeletal mass area (SMA) was quantified with the NIH ImageJ software in CT cross-sectional images at the L3 vertebrae region. Statistical analysis was performed with IBM SPSS v25 software https://www.ibm.com/analytics/spss-statistics-software. The median age was 62 (SD ± 11) years old, 65% were men and 62.9% had an Eastern Cooperative Oncology Group (ECOG) performance status of 0. The cut-off value was established based on ROC analysis, with sarcopenia defined as SMI < 49.12 cm2/m2 for men and < 35.85 cm2/m2 for women. Despite the mean body mass index (BMI) of 25.71 (± 4.71) kg/m2, half of the patients presented sarcopenia. In a multivariate analysis using a Cox regression model, an association was observed between OS and higher ECOG PS (p = 0.014; HR 5.46, CI 95% [1.42–21.10]), neutrophil-to-lymphocyte ratio (NLR) >2.80 (p = 0.038; HR 2.20, CI 95% [1,05–4.62]), and sarcopenia (p = 0.01; HR 4.73, CI 95% [1.85–12.09]). Additionally, in a logistic regression model, age (p = 0.014; OR 1.09, IC 95% [1.02–1.16]) and sarcopenia (p= 0.030, OR 4.13, IC 95% [1.15-14.8]) were associated with higher incidence of DLT. The CT evaluation of the body composition at the L3 region allows for the quantification of sarcopenia, providing prognostic information and predictive value of DLT in patients with mCRC, although the establishment of optimal cut-off values are required for implementation in clinical practice. A multimodal strategy to delay muscle waste should be considered in these patients.