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Is cold storage still a must? Evaluating room-temperature onabotulinumtoxinA for glabellar lines treatment
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Orientador(es)
Resumo(s)
Background: New botulinum toxin type A (BoNT-A) formulations eliminated cold-chain storage before reconstitution. Nonetheless, concerns remain about BoNT-A properties when stored at room temperature after reconstitution.
Aim: This study aimed to evaluate the sterility and effectiveness of BoNT-A storage at room temperature in glabellar wrinkles.
Methods: BoNT-A (Allergan Botox, Brazil) was reconstituted and maintained in a stove at 37°C for 60 days and then tested for sterility according to the Pharmacopeia guidelines. Then, sixty patients aged 25–60 years were divided into two groups: Group 1 (G1) received BoNT-A immediately after reconstitution, and Group 2 (G2) received BoNT-A after 7 days at room temperature. Participants were assessed for wrinkle severity using the Merz Scale, satisfaction with treatment using the Face-Q scale, and muscle activity by electromyography. Data were collected before injections and after 15, 30, 60, and 90 days.
Results: Absence of turbidity evidenced no microbial growth in all periods analyzed. Both groups showed significant reductions in glabellar contraction (p < 0.001), wrinkle severity (p < 0.05), and improved satisfaction. G1 presented lower wrinkle severity, while G2 reported higher satisfaction (p < 0.05).
Conclusion: Room temperature and longer storage periods may not affect OnabotulinumtoxinA sterility and clinical results.
Descrição
Palavras-chave
botulinum toxins type A reconstitution temperature
Contexto Educativo
Citação
R. Y. D. S. B.Rodriguez, G.De La Torre Canales, C. N.Giracca, et al., “Is Cold Storage Still a Must? Evaluating Room-Temperature OnabotulinumtoxinA for Glabellar Lines Treatment,” Journal of Cosmetic Dermatology, 24, no. 11 (2025): e70554, https://doi.org/10.1111/jocd.70554.
Editora
Wiley