Publicação
Is cold storage still a must? Evaluating room-temperature onabotulinumtoxinA for glabellar lines treatment
| datacite.subject.fos | Ciências Médicas::Ciências da Saúde | |
| datacite.subject.sdg | 03:Saúde de Qualidade | |
| dc.contributor.author | Rodriguez, Ruth Yimna Del Socorro Blanco | |
| dc.contributor.author | Canales, Giancarlo De La Torre | |
| dc.contributor.author | Giracca, César Nunes | |
| dc.contributor.author | Vaz, Thaís Caroline Schwartz Saldanha | |
| dc.contributor.author | Paulovski, Gislaine | |
| dc.contributor.author | Mendes, Lucas Alexandre de Sousa | |
| dc.contributor.author | Cordeiro, Jairo Matozinho | |
| dc.contributor.author | Murakami, Fábio Seigi | |
| dc.contributor.author | Câmara-Souza, Mariana Barbosa | |
| dc.date.accessioned | 2026-05-12T15:27:24Z | |
| dc.date.available | 2026-05-12T15:27:24Z | |
| dc.date.issued | 2025-11 | |
| dc.description.abstract | Background: New botulinum toxin type A (BoNT-A) formulations eliminated cold-chain storage before reconstitution. Nonetheless, concerns remain about BoNT-A properties when stored at room temperature after reconstitution. Aim: This study aimed to evaluate the sterility and effectiveness of BoNT-A storage at room temperature in glabellar wrinkles. Methods: BoNT-A (Allergan Botox, Brazil) was reconstituted and maintained in a stove at 37°C for 60 days and then tested for sterility according to the Pharmacopeia guidelines. Then, sixty patients aged 25–60 years were divided into two groups: Group 1 (G1) received BoNT-A immediately after reconstitution, and Group 2 (G2) received BoNT-A after 7 days at room temperature. Participants were assessed for wrinkle severity using the Merz Scale, satisfaction with treatment using the Face-Q scale, and muscle activity by electromyography. Data were collected before injections and after 15, 30, 60, and 90 days. Results: Absence of turbidity evidenced no microbial growth in all periods analyzed. Both groups showed significant reductions in glabellar contraction (p < 0.001), wrinkle severity (p < 0.05), and improved satisfaction. G1 presented lower wrinkle severity, while G2 reported higher satisfaction (p < 0.05). Conclusion: Room temperature and longer storage periods may not affect OnabotulinumtoxinA sterility and clinical results. | eng |
| dc.identifier.citation | R. Y. D. S. B.Rodriguez, G.De La Torre Canales, C. N.Giracca, et al., “Is Cold Storage Still a Must? Evaluating Room-Temperature OnabotulinumtoxinA for Glabellar Lines Treatment,” Journal of Cosmetic Dermatology, 24, no. 11 (2025): e70554, https://doi.org/10.1111/jocd.70554. | |
| dc.identifier.doi | 10.1111/jocd.70554 | |
| dc.identifier.issn | 1473-2165 | |
| dc.identifier.uri | http://hdl.handle.net/10400.26/63090 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.publisher | Wiley | |
| dc.relation.hasversion | https://doi.org/10.1111/jocd.70554 | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | botulinum toxins type A | |
| dc.subject | reconstitution | |
| dc.subject | temperature | |
| dc.title | Is cold storage still a must? Evaluating room-temperature onabotulinumtoxinA for glabellar lines treatment | eng |
| dc.type | contribution to journal | |
| dspace.entity.type | Publication | |
| oaire.citation.issue | 11 | |
| oaire.citation.startPage | e70554 | |
| oaire.citation.title | Journal of Cosmetic Dermatology | |
| oaire.citation.volume | 24 | |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 |