Percorrer por autor "Torres, M. Edite"
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- Bar adsorptive microextraction approach for trace determination of local anesthetics in urine matricesPublication . Pereira, Joana R. P.; Rocha, Daniela C.; Neng, Nuno R.; Maurício, Paulo; Torres, M. Edite; Ahmad, Samir M.; Quintas, AlexandreThe present work reports the development, optimization, and validation, of a methodology to determine lidocaine, procaine, tetracaine, and benzocaine in urine matrices. Two extractive preconcentration techniques, solid-phase microextraction (SPME) LC Tips and bar adsorptive microextraction (BAμE), were studied and applied to the four target anesthetics, followed by gas chromatography-mass spectrometry (GC-MS) analysis. Several parameters that could affect microextraction and back-extraction were optimized using two different designs of experiments (Box–Behnken and full-factorial) to maximize extraction efficiency from aqueous media. Under optimized experimental conditions, the BAμE technique showed better performance than SPME LC Tips and was chosen for validation assays and urine sample analysis. In blank urine, the BAµE/GC-MS methodology revealed suitable sensitivity (LOD between 2 and 18 ng/mL), good linearity (r2 ≥ 0.9945) between 0.5 and 30.0 µg/mL and recovery yields of 30.3–97.9%. Good precision (%RSD ≤ 8.8%) and accuracy (bias % between −15.9 and 15.0%) values were achieved. The developed methodology was successfully applied to the target anesthetics analysis of volunteers’ urine matrices and proved to be an environmentally friendly alternative to monitor trace levels of local anesthetics in complex matrices compared to other extraction techniques.
- Development of green approaches for preconcentration of local anesthetics in biological matricesPublication . Pereira, Joana; Rocha, Daniela C.; Neng, Nuno R.; Torres, M. Edite; Quintas, Alexandre; Ahmad, Samir M.Poster presented at the CQE Days - 5º encontro anual do Centro de Química Estrutural do Instituto Superior Técnico da Universidade de Lisboa. Lisboa, 25-26 may 2023
- Development of green methodologies for pre-concentration of local anaesthetics in biological matricesPublication . Pereira, Joana; Rocha, Daniela C.; Neng, Nuno R.; Torres, M. Edite; Quintas, Alexandre; Ahmad, Samir M.Poster presented at the 6th International Congress of CiiEM—Immediate and Future Challenges to Foster One Health. Monte de Caparica, 5-7 july 2023
- Novas abordagens verdes para determinação de anestésicos locais em matrizes biológicasPublication . Pereira, Joana R. P.; Rocha, Daniela C.; Neng, Nuno R.; Ahmad, Samir Marcos; Torres, M. Edite; Quintas, AlexandrePoster apresentado nas IV Jornadas Científicas Egas Moniz. Monte de Caparica, 27-30 novembro de 2023