Browsing by Author "Santos, C."
Now showing 1 - 8 of 8
Results Per Page
Sort Options
- Análise fotométrica da face: "starting from the outside in" [Revisão Narrativa]Publication . Baptista-Fernandes, M.; Cabral, M.; Santos, C.; Teles, I; Delgado, A. M.
- Biomechanical and physicochemical characterization of the rat’s osteoporotic bonePublication . Santos, C.; Carmezim, M. J.; Valido, A. J.; Colaço, B.; Fernandes, M. H.; Gomes, P.Osteoporosis is a clinical condition characterized by an increased risk of bone fracture. Structural fragility seems to result from a reduction in bone mass due to a decreased mineral content and impaired/altered protein synthesis. Despite the established knowledge on osteoporosis, little is known on how these compositional changes may affect the bone microarchitecture throughout different bones, and how these correlate with the attained increase of the fracture risk. This work aims to examine the relation between bone material properties and skeletal fragility in the femur, tibia, maxilla, mandible and calvarial structure of an animal model representative of the human osteoporotic condition, i.e., the ovariectomized Wistar rat. Two groups of animals, with 3 and 6 months following the induction of the osteoporotic condition were established, and bone tissue properties were compared to age-matched healthy controls. The biomechanical performance of different bones was tested by three-point bending. Structural (load-bearing capacity and stiffness), geometric (cross-sectional area, cortical sectional area, and moment of inertia) and material (modulus of elasticity and maximum elastic stress) properties were also evaluated, while morphological characterization was performed by FEGSEM. The organic content was determined by ash measurements and confocal Raman microscopy was used to evaluate compositional differences. Reported analyses showed that osteoporotic bones presented significant mechanical and morphological differences when compared with those from age-matched controls. Moreover, osteoporotic bones displayed a high ultimate tensile strength and were found to be more brittle than control bones. Attained differences could be related to the reduction in the collagen content, verified in osteoporotic conditions. These results highlight the role of the collagenous component in the structural and material properties of trabecular bone, and may account for the attained reduced bone mass in osteoporotic conditions.
- “Chaves” para análise facial em OrtodontiaPublication . Baptista-Fernandes, M.; Cabral, M.; Santos, C.; Teles, I.; Delgado, A. M.
- Dentinogénese Imperfeita – A propósito de um caso clínicoPublication . Bettencourt Lucas, A.; Santos, F.; Sobral Costa, T.; Santos, C.; Delgado, A.
- Organização e envolvimento no espaço educativo.Publication . Santos, C.; Cabral, A.P.
- Portuguese consensus document for the management of alpha-1-antitrypsin deficiencyPublication . Lopes, A.P.; Mineiro, M.A.; Costa, F.; Gomes, J.; Santos, C.; Antunes, C.; Maia, D.; Melo, R.; Canotilho, M.; Magalhães, E.; Vicente, I.; Valente, C.; Gonçalves, B.G.; Conde, B.; Guimarães, C.; Sousa, C.; Amado, J.; Brandão, M.E.; Sucena, M.; Oliveira, M.J.; Seixas, S.; Teixeira, V.; Telo, L.Alpha-1-antitrypsin deficiency (AATD) is a genetic autosomal codominant disorder caused by mutations in SERPINA1 gene. It is one of the most prevalent genetic disorders, although it remains underdiagnosed. Whereas at international level there are several areas of consensus on this disorder, in Portugal, inter-hospital heterogeneity in clinical practice and resources available have been adding difficulties in reaching a diagnosis and in making therapeutic decisions in this group of patients. This raised a need to draft a document expressing a national consensus for AATD. To this end, a group of experts in this field was created within the Portuguese Pulmonology Society - Study group on AATD, in order to elaborate the current manuscript. The authors reviewed the existing literature and provide here general guidance and extensive recommendations for the diagnosis and management of AATD that can be adopted by Portuguese clinicians from different areas of Medicine. This article is part of a supplement entitled "Portuguese consensus document for the management of alpha-1-antitrypsin deficiency" which is sponsored by Sociedade Portuguesa de Pneumologia.
- Saccharomyces cerevisiae as a toxicological model to study synthetic cannabinoids and its pyrolysis productsPublication . Ferreira, C.; Couceiro, J.; Soeiro, R.; Noronha, J.; Santos, C.; Outeiro, T.; Tenreiro, S.; Quintas, A."Synthetic cannabinoids are among the major psychoactive drugs widespread as safe and legal alternatives to cannabis. They are commercially available as herbal incense products intended for smoke. This has led most of developed countries to concentrate efforts in order to ban the so called “legal highs”. Despite of their increasing use, there is still a lack of information on both synthetic and natural ingredients, pharmacokinetic properties and toxic effects. In fact some of the substances seem to have stronger toxicological effects when compared to their legal counterpart. Toxicological assays are paramount to know how harmful these new substances are, helping increase public awareness since several hospitalization cases have been reported due to consumption. To tackle the new challenges posed by novel drugs worldwide, we developed an approach using Saccharomyces cerevisiae as a model to investigate the toxicity of pyrolysis products of synthetic cannabinoids. S. cerevisiae."
- Síndrome de Eagle: apresentação de um caso clínicoPublication . Furão, S.; Santos, P. F.; Silva, C.; Santos, C.; Teles, I.; Delgado, A.