Browsing by Author "Portugal, Jaime"
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- Challenges in matrix metalloproteinases inhibitionPublication . Laronha, Helena; Carpinteiro, Inês; Portugal, Jaime; Azul, Ana; Polido, Mário; Petrova, Krasimira T.; Salema-Oom, Madalena; Caldeira, JorgeMatrix metalloproteinases are enzymes that degrade the extracellular matrix. They have different substrates but similar structural organization. Matrix metalloproteinases are involved in many physiological and pathological processes and there is a need to develop inhibitors for these enzymes in order to modulate the degradation of the extracellular matrix (ECM). There exist two classes of inhibitors: endogenous and synthetics. The development of synthetic inhibitors remains a great challenge due to the low selectivity and specificity, side effects in clinical trials, and instability. An extensive review of currently reported synthetic inhibitors and description of their properties is presented.
- Influência da clorexidina na resistência adesiva à dentina : duas estratégias adesivasPublication . Carpinteiro, Inês; Melo, Teresa; Pinto, Alexandra; Fernandes, Inês Caldeira; Azul, Ana Cristina; Portugal, Jaime
- Resistência adesiva ao ProRoot® MTA e BIODENTINE™ com diferentes estratégias adesivasPublication . Batista, Melissa; Portugal, Jaime; Polido, Mário; Pereira, Mário Rito; Azul, Ana Cristina