Polymerizable matrix metalloproteinases’ inhibitors with potential application for dental restorations

Collagen cleavage by matrix metalloproteinase (MMP) is considered a major cause of dental resins long term failure. Most MMP inhibitors display significant toxicity and are unsuitable for dental resins’ applications. Here we report a study of a new class of inhibitors that display the unique property of being co-polymerizable with other vinyl compounds present in commercial dental resins, limiting their release and potential toxicity. Computational affinity towards the active site of different MMP-1; -2; -8; -9 and -13 of several compounds showed interesting properties and were synthesized. These free compounds were tested concerning their toxicity upon contact with two different cell types, with no substantial decrease in cell viability at high concentrations. Even so, compound’s safety can be further improved upon copolymerization with commercial dental resins, limiting their release.

Keywords

matrix metalloproteinases Inhibitors of matrix metalloproteinases citotoxicity

URI

http://hdl.handle.net/10400.26/59043

Citation

Laronha H, Carpinteiro I, Portugal J, Azul A, Polido M, Petrova KT, Salema-Oom M, Barahona I, Caldeira J. Polymerizable Matrix Metalloproteinases’ Inhibitors with Potential Application for Dental Restorations. Biomedicines. 2021; 9(4):366. https://doi.org/10.3390/biomedicines9040366