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Polymerizable matrix metalloproteinases’ inhibitors with potential application for dental restorations

datacite.subject.fosCiências Médicas
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorLaronha, Helena
dc.contributor.authorCarpinteiro, Inês
dc.contributor.authorPortugal, Jaime
dc.contributor.authorAzul, Ana
dc.contributor.authorPolido, Mário
dc.contributor.authorPetrova, Krasimira T.
dc.contributor.authorSalema-Oom, Madalena
dc.contributor.authorBarahona, Isabel
dc.contributor.authorCaldeira, Jorge
dc.date.accessioned2025-10-10T09:47:47Z
dc.date.available2025-10-10T09:47:47Z
dc.date.issued2021-04
dc.description.abstractCollagen cleavage by matrix metalloproteinase (MMP) is considered a major cause of dental resins long term failure. Most MMP inhibitors display significant toxicity and are unsuitable for dental resins’ applications. Here we report a study of a new class of inhibitors that display the unique property of being co-polymerizable with other vinyl compounds present in commercial dental resins, limiting their release and potential toxicity. Computational affinity towards the active site of different MMP-1; -2; -8; -9 and -13 of several compounds showed interesting properties and were synthesized. These free compounds were tested concerning their toxicity upon contact with two different cell types, with no substantial decrease in cell viability at high concentrations. Even so, compound’s safety can be further improved upon copolymerization with commercial dental resins, limiting their release.eng
dc.identifier.citationLaronha H, Carpinteiro I, Portugal J, Azul A, Polido M, Petrova KT, Salema-Oom M, Barahona I, Caldeira J. Polymerizable Matrix Metalloproteinases’ Inhibitors with Potential Application for Dental Restorations. Biomedicines. 2021; 9(4):366. https://doi.org/10.3390/biomedicines9040366
dc.identifier.doi10.3390/biomedicines9040366
dc.identifier.issn2227-9059
dc.identifier.urihttp://hdl.handle.net/10400.26/59043
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relation.hasversionhttps://doi.org/10.3390/biomedicines9040366
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectmatrix
dc.subjectmetalloproteinases
dc.subjectInhibitors of matrix metalloproteinases
dc.subjectcitotoxicity
dc.titlePolymerizable matrix metalloproteinases’ inhibitors with potential application for dental restorationseng
dc.typecontribution to journal
dspace.entity.typePublication
oaire.citation.issue4
oaire.citation.startPage366
oaire.citation.titleBiomedicines
oaire.citation.volume9
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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