Browsing by Author "Pinto, J. F."
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- Child-driven design of milk micelles for drug deliveryPublication . Fernandes, T.; Aguiar, J.; Scheppe, S.; Pinto, J. F.; Fernandes, A. I.
- Co-amorphization of olanzapine and saccharin : a pathway to increase solubility in waterPublication . Costa, N. F. da; Fernandes, A. I.; Pinto, J. F.
- Development of casein micellar pediatric formulationsPublication . Brachkova, M. I.; Pinto, J. T.; Fernandes, A. I.; Pinto, J. F."The current need for medicines specifically designed for children, which consider ease of administration, dose flexibility, palatability, safety of excipients, stability and therapeutic equivalency of pediatric dosage forms, has driven the development of pediatric drug formulations. In the present work casein (CN) based micellar formulations are evaluated as vehicles for the oral delivery of pediatric drugs, since caseins are nontoxic, biodegradable, GRAS materials and nanoencapsulation of drugs can improve their bioavailability. Chemical crosslinking of casein by carbodiimide (EDC) has been studied as an approach to improve the stability of the CN micelles and to tailor drug release."
- Evaluation of the ability of powdered milk to produce mini-tablets containing paracetamolPublication . Pinto, J. T.; Brachkova, M. I.; Fernandes, A. I.; Pinto, J. F."In recent years the development of medicines for paediatric use have gained increase interest. Small, flexible solid dosage forms, such as mini-tablets, are an attractive choice when developing new medicines for children. Excipients, though innocuous in adults, may pose a threat to the different paediatric age groups and, therefore, milk, a complete, universally accepted food, used in children’s diet since birth, seems to be an innovative and attractive excipient when formulating for the aforementioned population. In this study a full factorial design was employed to identify the variables (both formulation and manufacturing) and their interactions with significant impact on selected properties of mini-tablets, containing paracetamol and powdered milk, produced by direct compression."
- HPLC determination of theophylline and paracetamol in fresh and powdered milkPublication . Fernandes, T.; Aguiar, J.; Pinto, J. F.; Fernandes, A. I."Theophylline and paracetamol are drugs used worldwide both in human and veterinary medicine. Paracetamol (or acetaminophen) is employed as analgesic and antipyretic, and theophylline is a bronchodilator drug used in the treatment of asthma and chronic obstructive pulmonary disease. Both drugs are extensively used in pediatrics and their dosage is based on the child's body weight. Due to possible liver toxicity (paracetamol) and narrow therapeutic index (theophylline) it is imperative to carefully select and monitor the dose administered to children. Additionally, the recent proposal of milk as a platform to deliver drugs in pediatrics has prompted the development of a simple and sensitive high-performance liquid chromatography (HPLC) quantification method, of both theophylline and paracetamol, in the complex matrix that milk represents."
- Medicinal powders made of fresh milk for pediatric usePublication . Aguiar, J. P.; Fernandes, T.; Nese, C.; Pinto, J. F.; Fernandes, A. I."Nowadays, the need to formulate medicines specifically designed for children is imperative [1] and solid dosage forms are the first choice for providing the required drug stability and dose accuracy. Milk, as a worldwide accepted food, is proposed in this study as a platform to deliver drugs orally in pediatrics. Therefore, the main goals of this project are: (a) to assess the properties of spray-dried milk powders, (b) to evaluate drug-milk interactions and (c) to ascertain the stability of the spray-dried milk powders."
- Milk as a drug delivery platform in paediatricsPublication . Aguiar, J. P.; Fernandes, T.; Nese, C.; Fernandes, A. I.; Pinto, J. F."Purpose: to assess the physical properties of spray dried milk powders and evaluate drug-milk interactions."
- Simple and sensitive HPLC determination of paracetamol and theophylline in fresh and powdered milkPublication . Fernandes, T. A.; Aguiar, J. P.; Fernandes, A. I.; Pinto, J. F.
- Spray-dried fresh milk powders for oral drug delivery in pediatricsPublication . Aguiar, J. P.; Fernandes, T. A.; Nese, C.; Fernandes, A. I.; Pinto, J. F.