Evaluation of the ability of powdered milk to produce mini-tablets containing paracetamol

Pinto, J. T.; Brachkova, M. I.; Fernandes, A. I.; Pinto, J. F.

http://hdl.handle.net/10400.26/13402

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Abstract(s)

"In recent years the development of medicines for paediatric use have gained increase interest. Small, flexible solid dosage forms, such as mini-tablets, are an attractive choice when developing new medicines for children. Excipients, though innocuous in adults, may pose a threat to the different paediatric age groups and, therefore, milk, a complete, universally accepted food, used in children’s diet since birth, seems to be an innovative and attractive excipient when formulating for the aforementioned population. In this study a full factorial design was employed to identify the variables (both formulation and manufacturing) and their interactions with significant impact on selected properties of mini-tablets, containing paracetamol and powdered milk, produced by direct compression."