Browsing by Author "Oom, Madalena Salema"
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- Evidence for loss and reacquisition of alcoholic fermentation in a fructophilic yeast lineagePublication . Gonçalves, Carla; Wisecaver, Jennifer H.; Kominek, Jacek; Oom, Madalena Salema; Leandro, Maria José; Shen, Xing-Xing; Opulente, Dana A.; Zhou, Xiaofan; Peris, David; Kurtzman, Cletus P.; Hittinger, Chris Todd; Rokas, Antonis; Gonçalves, PaulaFructophily is a rare trait that consists of the preference for fructose over other carbon sources. Here, we show that in a yeast lineage (the Wickerhamiella/Starmerella, W/S clade) comprised of fructophilic species thriving in the high-sugar floral niche, the acquisition of fructophily is concurrent with a wider remodeling of central carbon metabolism. Coupling comparative genomics with biochemical and genetic approaches, we gathered ample evidence for the loss of alcoholic fermentation in an ancestor of the W/S clade and subsequent reinstatement through either horizontal acquisition of homologous bacterial genes or modification of a pre-existing yeast gene. An enzyme required for sucrose assimilation was also acquired from bacteria, suggesting that the genetic novelties identified in the W/S clade may be related to adaptation to the high-sugar environment. This work shows how even central carbon metabolism can be remodeled by a surge of HGT events.
- Influence of intensive training on salivary flow, on salivary pH and on salivary lactate concentration: consequences for oral healthPublication . Reis, Natacha; Oom, Madalena Salema; Vicente, Ana Filipa; Amorim, Armanda; Delgado, João; Godinho, Catarina
- Vitamin C content: fresh homemade vs. commercial orange juicesPublication . Raposo, Carolina Azaredo; Albuquerque, Tânia Gonçalves; Oom, Madalena Salema; Sanches-Silva, Ana; Costa, Helena S.