Browsing by Author "Miranda, Margarida"
Now showing 1 - 4 of 4
Results Per Page
Sort Options
- Amorphous nasal powder advanced performance : in vitro/ex vivo studies and correlation with in vivo pharmacokineticsPublication . Henriques, Patrícia; Bicker, Joana; Carona, Andreia; Miranda, Margarida; Vitorino, Carla; Doktorovová , Slavomíra; Fortuna, AnaPurpose: Amorphous solid dispersions (ASD) for nasal delivery offer the opportunity to increase drug release performance, while using polymers with mucoadhesive properties. The aim of the present study was to apply this solubility enhancement technique to a poorly soluble drug for nasal delivery, while comparing two particle engineering strategies, namely spray dried microparticles and chimeral agglomerates, with the corresponding physical blends with crystalline drug. Methods: Formulations of piroxicam were manufactured using varied polymer and particle engineering strategies and evaluated through in vitro drug release and ex vivo permeation studies, as well as nasal deposition and in vivo pharmacokinetic studies. Results: ASD with hydroxypropyl methylcellulose (HPMC) showed enhanced drug release and permeation, compared to polyvinylpyrrolidone/vinyl acetate formulations and blends. Nasal deposition of HPMC chimeral agglomerates suggested off-target deposition. In vivo pharmacokinetic studies revealed that spray-dried HPMC-containing microparticles exhibited the highest maximum plasma concentration (Cmax) and the lowest time to attain it (tmax). In vitro release rate and in vivo absorption rate were correlated as well as tmax and in vitro performance. When excluding the formulation with least nasal targeted deposition, in vitro release and ex vivo permeation performance were also correlated with Cmax and area under the drug concentration-time curve (AUC) from 0 to 1 h, with R2 > 0.89. Conclusion: ASD for nasal delivery provide fast drug absorption, which depends on the supersaturation ability of the polymer employed. In vitro-in vivo correlations suggested that in vitro release and ex vivo permeation studies are predictive tools regarding nasal absorption.
- Bridging generations through integrative learning, research, and community care : The ESPIEM ProjectPublication . Auxtero, Maria Deolinda; Costa, Isabel Margarida; Brito, José; Figueiredo, Alexandra; Ascenso, Carla; Miranda, Margarida; Caneiras, Cátia; Fernandes, Ana IsabelCommunication abstract presented at the EAFP Annual Conference 2025 – “Pharmaceutical Education & Research: SWOT Analysis”. Faculty of Pharmacy, University of Coimbra, 13th-15th of May 2025
- Non multa sed multum - Américo da Costa Ramalho 1921-2021Publication . Miranda, Margarida; Academia das Ciências de Lisboa
- The trends of Portugal’s 100 most popular sunscreens : a cosmetic consumer profiling studyPublication . Miquelino, Inês; Miranda, Margarida; Raposo, Sara; Auxtero, Maria DeolindaPoster presented at the 7th CiiEM International Congress: Empowering One Health to Reduce Social Vulnerabilities. Monte de Caparica, 2-4 july 2025