Percorrer por autor "Marques, Carolina"
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- Análise de discurso infantil: da avaliação à intervenção – ferramentas para o portuguêsPublication . Castro, Ana; Marques, Carolina; Doro, Catarina
- The asymmetric Petasis borono-Mannich reaction : insights on the last 15 yearsPublication . Marques, Carolina; Brandão, PedroThe Petasis borono-Mannich reaction, commonly described as the Petasis reaction, was one of the latest famous multicomponent reactions described in the literature. Currently celebrating its 30th anniversary since it was first reported by Petasis and Akritopoulou in 1993, this reaction has emerged as a powerful tool for the synthesis of biologically relevant molecules (such as substituted amines or amino acids), among others. This three-component catalyst-free reaction (the classic model), involving the coupling of an aldehyde, an amine, and a boronic acid, enables the synthesis of polysubstituted amine-containing molecules. Several accounts regarding the catalyst-free version using different carbonyl, amine, and boron-type components have been reported thus far. In contrast, the asymmetric version is still in its infancy since it was first reported in 2007. In this work, we aim to review the asymmetric versions of the Petasis reaction reported over the last 15 years, considering the chiral pool approach (asymmetric induction by one reaction component) and the use of catalysts (organocatalysts, transition-metal catalysts, and others) to access enantiomeric and diastereomeric pure amino-derivatives. Insights regarding the catalyzed Petasis reaction and consequent sustainable synthesis will be highlighted.
- A defesa da medicina legal aos olhos de Sousa MartinsPublication . Marques, Manuela; Cantante, Raquel; Marques, Carolina; Gonçalves, Rui; Teixeira, Helena M.O Médico, Farmacêutico, Professor, Cientista e Humanista, José Tomaz de Sousa Martins, foi uma personalidade nacional marcante do século XIX. Entre os seus múltiplos interesses encontra-se a área da Medicina Legal, tendo sido um dos seus maiores defensores, procurando a sua valorização no âmbito da Justiça.Como membro da Sociedade de Ciências Médicas de Lisboa, Sousa Martins participou em diversas discussões de interesse médico-legal, nomeadamente no debate sobre a utilização do chumbo e do zinco no revestimento interno de reservatórios de água potável, bem como na identificação de casos de saturnismo, ocorrências que Sousa Martins atribuía à questão do rapé ser vendido em pacotes revestidos a folha de chumbo. Não menos importantes foram as questões que levantou sobre a importância do segredo médico e sobre a imparcialidade e independência que os médicos deveriam atender nos pareceres médico-legais. É, ainda, de referir, que a sua primeira comunicação nesta sociedade versou sobre um suposto caso de suicídio por ingestão de fósforo, onde Sousa Martins, na procura sobre as eventuais causas de morte através da autópsia médico legal, evidenciou a importância da realização de exames complementares. No âmbito da valorização do perito, publicou diversos artigos na imprensa médica, defendendo que a justiça não devia solicitar perícias “ao primeiro intimado, agarrado e ajuramentado” apenas porque possuía um diploma de medicina, pois era importante formação especifica para além da necessidade de uma organização médico-legal. E é nesta linha de pensamento que o Prof. Sousa Martins se liga igualmente ao mediático caso “Joana Pereira”, tendo integrado a equipa médica (juntamente com Manuel Bento de Sousa e Curry Cabral) que realizou as perícias no cadáver encontrado em Mafra em 1876, concluindo que a morte do individuo deste caso se devia a asfixia por estrangulamento, levantando, desta forma, a suspeita de homicídio. Em Tribunal, a defesa dos suspeitos de homicídio (que alegavam que a vítima se tinha suicidado através de enforcamento), solicita um parecer a outros 3 médicos que não confirmam a hipótese de estrangulamento. A Justiça acabou por absolver os suspeitos de crime, o que contrariou as conclusões das perícias médicas realizadas. O desfecho judicial deste caso levou Sousa Martins e os outros peritos, que foram responsáveis pelos exames médico-legais, a publicarem um valioso trabalho que envolveu pareceres de 30 médicos, de 16 países da Europa, concluindo que as lesões descritas no relatório pericial eram compatíveis com estrangulamento e não com uma situação de enforcamento, indo ao encontro do pressuposto da etiologia homicida, confirmando assim as conclusões da autópsia médico-legal realizada. O presente trabalho visa, assim, valorizar e dar a conhecer a figura de Sousa Martins na História da Medicina Legal em Portugal, no período antecessor à publicação da organização dos serviços médico-legais no nosso país, o que só viria a ocorrer em 1899.
- Evaluating the quality of systematic reviews on pediatric sedation in dentistry : an umbrella reviewPublication . Marques, Carolina; Dinis, Mafalda; Machado, Vanessa; Botelho, João; Lopes, Luísa BandeiraSedation is a depression of a patient’s state of consciousness, induced by medications, that can reach different levels of intensity during a medical procedure. Conscious sedation produces a minimally depressed level of consciousness without impairment of the ability to maintain an open airway, of protective reflexes or of responses to verbal and physical stimulation. This umbrella review is aimed at critically assessing the available systematic reviews (SRs) and meta-analyses (MA) on sedation in children/adolescents. An electronic database search was conducted that included Pubmed-Medline, Web of Science, Cochrane, Scopus, Scielo, Embase, LILACS and TRIP and the scope of which extended until January 2023. The risk of bias (RoB) of SRs was analyzed using the Measurement Tool to Assess SRs criteria 2 (AMSTAR2). Of 998 entries, 37 SRs were included. In terms of methodological quality, eight studies were assessed as having critically low quality, four studies had low quality, nine studies had moderate quality, and sixteen were considered to be of high quality. Based on the current guidelines, the most employed drugs in pediatric dentistry for sedation are nitrous oxide and midazolam; however, the available evidence supporting their use is insufficient and of low/critically low quality. The combined technique is recommended (nitrous oxide (30–50%) + midazolam). The optimal dose of oral midazolam is 0.75 mg/kg. The level of methodological quality of SRs is expected to increase according to the results and future directions of this umbrella review.
- From the assessment of speech samples to intervention in language impairment of European Portuguese speaking childrenPublication . Castro, Ana; Dôro, Catarina; Marques, Carolina
- International guidelines on conscious sedation in pediatric dentistry : a comparative analysis and evidence mapping studyPublication . Marques, Carolina; Dinis, Mafalda; Botelho, João; Machado, Vanessa; Lopes, Luísa BandeiraConscious sedation is widely used in pediatric dentistry to manage dental anxiety, behavioral difficulties, and systemic diseases that compromise patient compliance with dental care. Despite its clinical importance, international recommendations vary considerably. Objective: To conduct a comparative analysis and evidence mapping of international clinical practice guidelines on conscious sedation in pediatric dentistry. Methods: A comparative guideline analysis and evidence mapping study was performed. Electronic searches were conducted in PubMed (MEDLINE), Scopus, EMBASE, Cochrane Database of Systematic Reviews, Web of Science, LILACS, SciELO, TRIP, and OpenGrey up to December 2023. Guidelines issued by recognized professional or governmental organization addressing conscious sedation in pediatric dentistry were included. Predefined domains were analyzed, including indications, contraindications, pharmacological agents, dosages, routes of administration, monitoring, discharge criteria, and professional training. Data were synthesized descriptively and graphically mapped to illustrate coverage patterns. Results: Twelve international guidelines were included. Complete convergence (100%) was observed in core safety domains, such as patient assessment, monitoring, and professional training. A high agreement was found for discharge criteria (91.67%) and contraindications (83.33%). However, substantial variability emerged in pharmacological protocols, with only 16.67% of guidelines providing comprehensive drug and dosage descriptions. Routes of administration and emergency equipment recommendations were inconsistently reported, appearing in 66.67% and 50% of guidelines, respectively. Conclusions: Although foundational safety principles are consistently addressed, significant heterogeneity persists in pharmacological and procedural recommendations. This variability may contribute to differences in practice and uncertainty among practitioners. Greater international harmonization of guidelines may improve consistency, enhance clinical decision-making, and strengthen patient safety in pediatric dental care. Clinical Relevance: Identifying areas of convergence and variability across international guidelines may support the development of more standardized sedation protocols and promote safer evidence-based clinical practice in pediatric dentistry.
- A procedure for morphosyntactic analysis of European Portuguese speaking children's spontaneous language samplesPublication . Castro, Ana; Marques, Carolina; Dôro, Catarina