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Browsing by Author "Coelho, Miguel"

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  • Action verbal fluency in Parkinson’s patients
    Publication . Tello Rodrigues, Inês; Ferreira, Joaquim; Coelho, Miguel; Rosa, Mário; Castro-Caldas, Alexandre
    We compared the performance of 31 non-demented Parkinson´s disease (PD) patients to 61 healthy controls in an action verbal fluency task. Semantic and phonemic fluencies, cognitive impairment and behavioural dysfunction were also assessed. The mean disease duration of PD was 9.8 years (standard deviation (SD) = 6.13). There were no age (U = 899.5, p = 0.616), gender(chi-square = 0.00, p = 1.00) or literacy (U = 956, p = 0.96) differences between the two groups. A significant difference was observed between the two groups in the action verbal fluency task (U = 406.5, p < 0.01) that was not found in the other fluency tasks. The education level was the only biographical variable that influenced the action (verb) fluency outcomes, irrespective of disease duration. Our findings suggest a correlation between the disease mechanisms in PD and a specific verb deficit, support the validity of the action (verb) fluency as an executive function measure and suggest that this task provides unique information not captured with traditional executive function tasks.
    2015-02-25Journal article Open access Show more
  • Avaliação do Estado Mental para Estimulação Cerebral Profunda: “ON” vs. “OFF”
    Publication . Freitas, Vanda; Coelho, Miguel; Albuquerque, Luísa; Godinho, Catarina; Rosa, Mário Miguel; Martins, Isabel Pavão
    2015-03-13Conference object Open access Show more
  • Clinical diagnostic criteria have a high impact on the frequency of dementia in late-stage Parkinson's disease
    Publication . Sousa, Catarina Severiano e; Fabbri, Margherita; Godinho, Catarina; Simões, Rita; Chendo, Inês; Coelho, Miguel; Martins, Isabel Pavão; Ferreira, Joaquim J.
    Background: Cognitive impairment is a potential late feature of Parkinson's disease (PD). However, studies in patients with late-stage PD are lacking due to the particular characteristics of this population.
    2021-05Journal article Open access Show more
  • Clinical rating scale for pantothenate kinase-associated neurodegeneration: A pilot study
    Publication . Darling, Alejandra; Tello, Cristina; Martí, María Josep; Garrido, Cristina; Aguilera-Albesa, Sergio; Tomás Vila, Miguel; Gastón, Itziar; Madruga, Marcos; González Gutiérrez, Luis; Ramos Lizana, Julio; Pujol, Montserrat; Gavilán Iglesias, Tania; Tustin, Kylee; Lin, Jean Pierre; Zorzi, Giovanna; Nardocci, Nardo; Martorell, Loreto; Lorenzo Sanz, Gustavo; Gutiérrez, Fuencisla; García, Pedro J.; Vela, Lidia; Hernández Lahoz, Carlos; Ortigoza Escobar, Juan Darío; Martí Sánchez, Laura; Moreira, Fradique; Coelho, Miguel; Correia Guedes, Leonor; Castro Caldas, Ana; Ferreira, Joaquim; Pires, Paula; Costa, Cristina; Rego, Paulo; Magalhães, Marina; Stamelou, María; Cuadras Pallejà, Daniel; Rodríguez-Blazquez, Carmen; Martínez-Martín, Pablo; Lupo, Vincenzo; Stefanis, Leonidas; Pons, Roser; Espinós, Carmen; Temudo, Teresa; Pérez Dueñas, Belén
    Pantothenate kinase-associated neurodegeneration is a progressive neurological disorder occurring in both childhood and adulthood. The objective of this study was to design and pilot-test a disease-specific clinical rating scale for the assessment of patients with pantothenate kinase-associated neurodegeneration.
    2017-08-28Journal article Open access Show more
  • Cognitive impairment in fall-related studies in Parkinson’s Disease
    Publication . Domingos, Josefa M.; Godinho, Catarina; Dean, John; Coelho, Miguel; Pinto, Anabela; Bloem, Bastiaan R.; Ferreira, Joaquim J.
    2015-09Journal article Open access Show more
  • Disability in activities of daily living and severity of dyskinesias determine the handicap of Parkinson´s disease patients in advanced stage selected to dbs
    Publication . Coelho, Miguel; Abreu, Daisy; Correia-Guedes, Leonor; Lobo, Patrícia Pita; Fabbri, Margherita; Godinho, Catarina; Domingos, Josefa; Albuquerque, Luisa; Freitas, Vanda; Pereira, João Miguel; Cattoni, Begona; Carvalho, Herculano; Reimão, Sofia; Rosa, Mário M.; Ferreira, António Gonçalves; Ferreira, Joaquim J.
    "BACKGROUND: There is scarce data on the level of handicap in Parkinson's disease (PD) and none in advanced stage PD. OBJECTIVE: To assess the handicap in advanced stage PD patients with disabling levodopa-induced motor complications selected to deep brain stimulation (DBS). METHODS: Data was prospectively recorded during routine evaluation for DBS. Handicap was measured using London Handicap Scale (LHS) (0 = maximal handicap; 1 = no handicap). Disease severity was evaluated using the Hoehn & Yahr scale and the UPDRS/MDS-UPDRS, during off and on after a supra-maximal dose of levodopa. Schwab and England Scale (S&E) was scored in off and on. Dyskinesias were scored using the modified Abnormal Involuntary Movement Scale (mAIMS). Results concern cross-sectional assessment before DBS. RESULTS: 100 PD patients (mean age 61 (±7.6); mean disease duration 12.20 (±4.6) years) were included. Median score of motor MDS-UPDRS was 54 in off and 25 in on. Mean total LHS score was 0.56 (±0.14). Patients were handicapped in several domains with a wide range of severity. Physical Independence and Social Integration were the most affected domains. Determinants of total LHS score were MDS-UPDRS part II off (β= -0.271; p = 0.020), S&E on (β= 0.264; p = 0.005) and off (β= 0.226; p = 0.020), and mAIMS on (β= -0.183; p = 0.042) scores (R2  = 29.6%). CONCLUSIONS: We were able to use handicap to measure overall health condition in advanced stage PD. Patients were moderately to highly handicapped and this was strongly determined by disability in ADL and dyskinesias. Change in handicap may be a good patient-centred outcome to assess efficiency of DBS."
    2017Journal article Restricted access Show more
  • Dysphagia predicts poor outcome in late-stage Parkinson's disease
    Publication . Fabbri, Margherita; Coelho, Miguel; Abreu, Daisy; Guedes, Leonor Correia; Rosa, Mario M.; Godinho, Catarina; Cardoso, Rita; Guimarães, Isabel; Antonini, Angelo; Zibetti, Maurizio; Lopiano, Leonardo; Ferreira, Joaquim J.
    "BACKGROUND: Few data exist on the rate of clinical progression for Parkinson's disease (PD) patients who have entered a late stage of the disease. OBJECTIVE: Study the clinical progression of a late-stage PD (LSPD) population over one year follow-up. METHODS: 50 LSPD patients (Schwab and England ADL Scale <50 or Hoehn Yahr Stage >3 in MED ON) underwent an extensive clinical assessment at baseline and after one year and an acute levodopa test at baseline. RESULTS: Mean age of LSPD patients (female 46%) was 77.5 ± 5.9 years and mean disease duration was 15.5 ± 6.5 years. At baseline, 76% had levodopa-induced motor complications (MC), usually non-troublesome, 68% were demented, 54% had psychosis and 68% depression. Caregiver distress was high. l-dopa responsiveness was mild (18% ± 12 of improvement on MDS-UPDRS-III). After one-year, 20% of the patients were dead, institutionalized or HY 5. MDS-UPDRS-motor mean score worsened 7.2 ± 10.3 points although there was heterogeneity between patients, and there was a global worsening of non-motor symptoms, mostly in cognition/mood, urinary and gastrointestinal domains. Nevertheless, MC improved despite similar levodopa equivalent dose. Functional independence and quality of life worsened. Dysphagia severity at baseline predicted a poor outcome (death, institutionalization or HY 5) (Hazard ratio 2.3, 95% CI 1.12-4.4; p = 0.01), whereas magnitude of l-dopa response of LSPD patients did not. CONCLUSIONS: LSPD patients still present a significant, although heterogeneous, motor and non-motor progression over 1 year. Dysphagia severity predicts the occurrence of additional disease severity milestones and its management must be prioritized."
    2019-07Journal article Open access Show more
  • Dysphagia predicts poor outcome in late-stage Parkinson's disease
    Publication . Fabbri, Margherita; Coelho, Miguel; Abreu, Daisy; Guedes, Leonor Correia; Rosa, Mario M; Godinho, Catarina; Cardoso, Rita; Guimarães, Isabel; Antonini, Angelo; Zibetti, Maurizio; Lopiano, Leonardo; Ferreira, Joaquim J
    2019-02-25Journal article Restricted access Show more
  • High frequency of psychosis in late-stage Parkinson’s disease
    Publication . Chendo, Inês; Fabbri, Margherita; Godinho, Catarina; Simões, Rita Moiron; Sousa, Catarina Severiano; Coelho, Miguel; Voon, Valerie; Ferreira, Joaquim J.
    Background Psychosis is a frequent non-motor symptom in Parkinson’s disease (PD). Estimates of the frequency of Parkinsońs disease psychosis (PDP) vary widely. Knowledge about the frequency and phenomenology of psychosis in late-stage (LS) PD patients is limited. This study aimed to determine the frequency of psychosis in LSPD patients through clinical diagnostic interview (CDI) (gold standard), according to NINDS/NIMH diagnostic criteria for PDP. The secondary objectives were to characterize the phenomenology, to test selected instruments and assess their adequacy in comparison to CDI, and to assess the psychiatric comorbidities.
    2021Journal article Open access Show more
  • Main reasons for rejection of deep brain stimulation surgery in candidates with Parkinson Disease
    Publication . Sousa, Teresa Almeida e; Ferret-Sena, Véronique; Coelho, Miguel; Correia-Guedes, Leonor; Fabbri, Margherita; Rosa, Mário Miguel; Godinho, Catarina
    2017-06-11Conference object Open access Show more