Browsing by Author "Cardoso, J"
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- Asthma management with breath-triggered inhalers: innovation through designPublication . Morais-Almeida, M; Pité, H; Cardoso, J; Costa, R; Robalo-Cordeiro, C; Silva, E; Todo-Bom, A; Vicente, C; Agostinho-Marques, JBackground: Asthma affects the lives of hundred million people around the World. Despite notable progresses in disease management, asthma control remains largely insufficient worldwide, influencing patients' wellbeing and quality of life. Poor patient handling of inhaling devices has been identified as a major persistent problem that significantly reduces inhaled drugs' efficacy and is associated with poor adherence to treatment, impairing clinical results such as asthma control and increasing disease-related costs. We herein review key research and development (R&D) innovation in inhaler devices, highlighting major real-world critical errors in the handling and inhalation technique with current devices and considering potential solutions. Furthermore, we discuss current evidence regarding breath-triggered inhalers (BTI). Main body: The two most common significant problems with inhalers are coordinating actuation and inhalation with pressurized metered-dose inhalers (pMDIs), and the need to inhale forcibly with a dry powder inhaler. BTI R&D plans were designed to overcome these problems. Its newest device k-haler® has several other important features, generating a less forceful aerosol plume than previous pMDIs, with efficient drug delivery and lung deposition, even in patients with low inspiratory flow. The local and systemic bioavailability of fluticasone propionate and formoterol (FP/FORM) administered via k-haler® has been shown to be therapeutically equivalent when administered via the previous FP/FORM pMDI. This device requires very few steps and has been considered easy to use (even at first attempt) and preferred by the patients in a randomized crossover study. In our country, FP/FORM k-haler is available without additional costs compared to FP/FORM pMDI. All devices continue to require education and regular checking of the correct inhalation technique. Conclusion: BTI R&D can bring advantage over current available inhalers, avoiding the two most common identified critical errors in inhalation technique. K-haler® BTI is currently available, without an increased cost, and approved for adolescents and adults with asthma in whom treatment with inhaled combined therapy with long-acting beta2-agonists and corticosteroids is indicated. Its attractive and practical design to facilitate its use has been awarded. K-haler® represents added value through innovation to fulfill actual asthma patient needs, thus with potential relevant impact in asthma management and effective control.
- Asthma-chronic obstructive pulmonary disease overlap syndrome - Literature review and contributions towards a Portuguese consensusPublication . Araújo, D; Padrão, E; Morais-Almeida, M; Cardoso, J; Pavão, F; Leite, R B; Caldas, A C; Marques, APhenotypic overlap between the two main chronic airway pulmonary diseases, asthma and chronic obstructive pulmonary disease (COPD), has been the subject of debate for decades, and recently the nomenclature of asthma-COPD overlap syndrome (ACOS) was adopted for this condition. The definition of this entity in the literature is, however, very heterogeneous, it is therefore important to define how it applies to Portugal.
- A False Step in a Ballerina: A Rare Case of Osteonecrosis of Subhallucal Sesamoid BonePublication . Maganinho, P; Sá Malheiro, F; Cardoso, J; Sampaio Macedo, C; Pereira, BSSubhallucal interphalangeal osteonecrosis is an uncommon cause of forefoot pain, and a rarely reported clinical entity, being often overlooked. Imaging, particularly computed tomography (CT) scan and magnetic resonance imaging (MRI) have an essential role in early and differential diagnosis and guiding for appropriate therapy. The first approach should be conservative, and surgical treatment should be considered when it proves ineffective. In this case report, we describe a rare case of hallucal interphalangeal osteonecrosis manifesting a long-term hallux discomfort, successfully managed through a conservative approach, and we discuss the role of imaging techniques in its diagnosis.
- Feasibility and Acceptability of an Asthma App to Monitor Medication Adherence: Mixed Methods StudyPublication . Jácome, C; Almeida, R; Pereira, AM; Amaral, R; Mendes, S; Alves-Correia, M; Vidal, C; López Freire, S; Méndez Brea, P; Araújo, L; Couto, M; Antolín-Amérigo, D; de la Hoz Caballer, B; Barra Castro, A; Gonzalez-De-Olano, D; Todo Bom, A; Azevedo, J; Leiria Pinto, P; Pinto, N; Castro Neves, A; Palhinha, A; Todo Bom, F; Costa, A; Chaves Loureiro, C; Maia Santos, L; Arrobas, A; Valério, M; Cardoso, J; Emiliano, M; Gerardo, R; Cidrais Rodrigues, JC; Oliveira, G; Carvalho, J; Mendes, A; Lozoya, C; Santos, N; Menezes, F; Gomes, R; Câmara, R; Rodrigues Alves, R; Moreira, AS; Bordalo, D; Alves, C; Ferreira, JA; Lopes, C; Silva, D; Vasconcelos, MJ; Teixeira, MFa; Ferreira-Magalhães, M; Taborda-Barata, L; Cálix, MJ; Alves, A; Almeida Fonseca, JBackground: Poor medication adherence is a major challenge in asthma, and objective assessment of inhaler adherence is needed. The InspirerMundi app aims to monitor adherence while providing a positive experience through gamification and social support. Objective: This study aimed to evaluate the feasibility and acceptability of the InspirerMundi app to monitor medication adherence in adolescents and adults with persistent asthma (treated with daily inhaled medication). Methods: A 1-month mixed method multicenter observational study was conducted in 26 secondary care centers from Portugal and Spain. During an initial face-to-face visit, physicians reported patients' asthma therapeutic plan in a structured questionnaire. During the visits, patients were invited to use the app daily to register their asthma medication intakes. A scheduled intake was considered taken when patients registered the intake (inhaler, blister, or other drug formulation) by using the image-based medication detection tool. At 1 month, patients were interviewed by phone, and app satisfaction was assessed on a 1 (low) to 5 (high) scale. Patients were also asked to point out the most and least preferred app features and make suggestions for future app improvements. Results: A total of 107 patients (median 27 [P25-P75 14-40] years) were invited, 92.5% (99/107) installed the app, and 73.8% (79/107) completed the 1-month interview. Patients interacted with the app a median of 9 (P25-P75 1-24) days. At least one medication was registered in the app by 78% (77/99) of patients. A total of 53% (52/99) of participants registered all prescribed inhalers, and 34% (34/99) registered the complete asthma therapeutic plan. Median medication adherence was 75% (P25-P75 25%-90%) for inhalers and 82% (P25-P75 50%-94%) for other drug formulations. Patients were globally satisfied with the app, with 75% (59/79) scoring ≥4,; adherence monitoring, symptom monitoring, and gamification features being the most highly scored components; and the medication detection tool among the lowest scored. A total of 53% (42/79) of the patients stated that the app had motivated them to improve adherence to inhaled medication and 77% (61/79) would recommend the app to other patients. Patient feedback was reflected in 4 major themes: medication-related features (67/79, 85%), gamification and social network (33/79, 42%), symptom monitoring and physician communication (21/79, 27%), and other aspects (16/79, 20%). Conclusions: The InspirerMundi app was feasible and acceptable to monitor medication adherence in patients with asthma. Based on patient feedback and to increase the registering of medications, the therapeutic plan registration and medication detection tool were redesigned. Our results highlight the importance of patient participation to produce a patient-centered and engaging mHealth asthma app.
- Teleconsultation in respiratory medicine – A position paper of the Portuguese Pulmonology SocietyPublication . Morais, A; Bugalho, A; Drummond, M; Ferreira, AJ; Oliveira, AS; Sousa, S; Winck, JC; Cardoso, JThe COVID-19 pandemic crisis, among so many social, economic and health problems, also brought new opportunities. The potential of telemedicine to improve health outcomes had already been recognised in the last decades, but the pandemic crisis has accelerated the digital revolution. In 2020, a rapid increase in the use of remote consultations occurred due to the need to reduce attendance and overcrowding in outpatient clinics. However, the benefit of their use extends beyond the pandemic crisis, as an important tool to improve both the efficiency and capacity of future healthcare systems. This article reviews the literature regarding telemedicine and teleconsultation standards and recommendations, collects opinions of Portuguese experts in respiratory medicine and provides guidance in teleconsultation practices for Pulmonologists.
- Volumoso quisto acromioclavicular como apresentação invulgar de rotura massiva da coifa dos rotadoresPublication . Karmali, S; Barbosa, N; Teixeira-Ramos, J; Almeida, J; Cardoso, J; Barros, A; Rosa, B; Lopes, A; Sá da Costa, D; Silva-Gomes, D; Quinaz-Neto, PObjetivo: Os quistos sinoviais da articulação acromioclavicular (AC), podem ocorrer associadas à artrose AC ou como consequência da rotura massiva da coifa dos rotadores. Com o presente caso, os autores pretendem apresentar e discutir uma situação pouco frequente. Relato de caso: Homem de 81 anos, referenciado à consulta de Ortopedia por tumefação da região superior do ombro direito, indolor e de aumento progressivo nos últimos 2 anos. Avaliação clínica e radiológica compatível com volumoso quisto sinovial da acromioclavicular, associado a rotura massiva da coifa dos rotadores; submetido a tratamento cirúrgico com excisão marginal da lesão; a análise anatomopatológica confirmou o diagnóstico de quisto sinovial. Comentários: Os quistos sinoviais da articulação AC são entidades raras e pouco abordadas na literatura. A sua etiologia permanece por esclarecer ainda que um dos tipos descritos pareça estar associada à omatrose com rotura massiva da coifa dos rotadores (artropatia da coifa); nestes, a rotura da coifa permite a passagem de grandes quantidades de líquido sinovial para o espaço subacromial com formação de um volumoso quisto. Atendendo à sua raridade, o tratamento permanece controverso. O caso vem alertar para a ocorrência dos quistos da articulação AC, como apresentação invulgar de artropatia das coifa dos rotadores, discutindo a sua etiologia e abordagem terapêutica adequada.