Percorrer por autor "Braga, Ana Cristina"
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- Associação da má oclusão de Classe II Divisão 2 com anomalias do desenvolvimento dentárioPublication . Pereira, Pedro Mariano; Ferreira, Afonso Pinhão; Tavares, Purificação; Braga, Ana Cristina
- Botulinum toxin effects on biochemical biomarkers related to inflammation-associated head and neck chronic conditions : a systematic review of clinical researchPublication . Pereira, Inês Novo; Durão, Sara; Hassan, Haidar; Braga, Ana Cristina; Almeida, André Mariz de; Manso, Ana Cristina; Faria- Almeida, Ricardo; Canales, Giancarlo De la TorreBotulinum toxin type A (BoNT) has emerged as a potential alternative to conventional therapies to many debilitating chronic diseases characterised by inflammatory states. However, the biological rationale remains ambiguous. Our review aimed to systematically assessed which biochemical biomarkers have been reported in clinical research to evaluate BoNT analgesic and mood-lifting effects in head and neck chronic conditions related to inflammation. We searched databases and registries between inception and September 29, 2023. Of the nine included studies, there were concerns about risk of bias for six studies. The leading biomarker with five studies was the calcitonin gene-related peptide (CGRP), followed by serotonin with two studies. Oxidative stress biomarkers were only reported in one study. Several important players in inflammatory processes and different immune cell classes have been evaluated in four studies. There was only one trial measuring changes in beta Tubulin and SNAP-25, and another study evaluating cutaneous neuropeptide substance-P. After BoNT, a significant effect was reported in six studies, including decrease in plasma levels of CGRP in chronic migraine and trigeminal neuralgia; serotonin decrease when collected from human tears in refractory intractable dry eye disease and increase in peripheral blood platelets in painful cervical dystonia associated to depression and anxiety; decrease in plasma concentration of markers of oxidative damage to proteins and increase in biomarkers for antioxidant power; decrease in expression of gene sets involved in inflammatory pathways and immune cells classes in the periosteum and metalloproteinase-9 molecule in the tears. BoNT seems to affect some biomarkers present in chronic inflammatory conditions. However, the certainty evidence found was very low to moderate. This study is registered on PROSPERO (CRD42023432131).
- Botulinum toxin effects on biochemical biomarkers related to inflammation-associated head and neck chronic conditions : a systematic review of preclinical researchPublication . Pereira, Inês Novo; Canales, Giancarlo De La Torre; Durão, Sara; Shado, Rawand; Braga, Ana Cristina; Almeida, André Mariz de; Hassan, Haidar; Manso, Ana Cristina; Faria-Almeida, RicardoCurrent research reported that the number of clinical studies found for botulinum toxin (BoNT) key effects on biochemical biomarkers in head and neck chronic conditions linked to inflammation was very low. There are no systematic reviews of animal studies on this topic, and hence our review aimed to evaluate the quality of the preclinical evidence. We searched PubMed, Scopus, and Web of Science databases, and registries up to 29 January 2024. There were 22 eligible records, and data were available for 11 randomised controlled trials. There were concerns about the risk of bias and great variations of data obtained regarding chronic conditions, which included mostly trigeminal neuralgia. The leading biomarkers were proinflammatory cytokines (IL-1β, TNF-α) and synaptosomal-associated protein-25 (SNAP25), followed by neuron activation marker c-Fos and calcitonin gene-related peptide (CGRP). Overall, data found that BoNT significantly altered the under/over-expression of biomarkers evoked by the investigated disease models and had no effect when the levels of these biomarkers were not changed by the induced chronic conditions in animals. However, there were some mixed results and exceptions, and the certainty evidence found was very low to low. Although the sample sizes detected significant effect size (p < 0.05), most studies are based on male inferior animals, which may limit the recommendations for clinical trials. This study is registered on PROSPERO (CRD42023432411).
- Different manifestations of Class II Division 2 incisor retroclination – Morphologic studyPublication . Pereira, Pedro Mariano; Ferreira, Afonso Pinhão; Tavares, Purificação; Braga, Ana Cristina"Introduction: The aim of the present study was to investigate whether there is a different transverse morphologic pattern of dental arches among the different manifestations of Class II Division 2 incisor retroclination and evaluate to what extent the pattern of smaller-than-average teeth in Class II Division 2 malocclusion is common to all groups studied. This information may clarify whether different Class II Division 2 phenotypes represent a single etiology or multiple etiologies. Methods: The sample comprised 108 Class II Division 2 malocclusions which were divided into two groups according to the type of incisor retroclination: Group I composed of 43 Class II Division 2 with retroclination exclusively of the maxillary central incisors; Group II composed of 65 Class II Division 2 with retroclination of the four maxillary incisors. Maxillary and mandibular intercanine and intermolar widths as well as the mesiodistal crown dimension of the four maxillary and mandibular incisors were determined using the initial study models of patients. Mean values of all variables were compared between the two groups by gender using ANOVA. Results: From the comparison between the two groups analyzed, no statistically significant differences were found for all transverse measurements (p>0.05). For all mesiodistal measurements analyzed, statistically significant differences between the groups were only found for the mean value of both maxillary lateral incisors mesiodistal dimension in both sexes (p<0.05). Conclusions: It is not possible to attribute a characteristic pattern of dental arch width and of incisor mesiodistal dimension to the different manifestations of incisor retroclination in Class II Division 2 malocclusion."
- Different manifestations of class II division 2 incisor retroclination and their association with dental anomaliesPublication . Pereira, Pedro Mariano; Ferreira, Afonso Pinhão; Tavares, Purificação; Braga, Ana Cristina"Objective: To investigate whether there is an association between dental development anomalies (DDAs) and the different manifestations of Class II Division 2 (CII/2) malocclusion incisor retroclination. This information may clarify whether the different CII/2 phenotypes, with regard to maxillary incisor retroclination, are a single clinical entity or etiologically different entities. Design: Retrospective comparative study. Setting: Private orthodontic practice in the regions of Lisbon and Porto, Portugal Subjects and Methods: The sample comprised 115 CII/2 malocclusions distributed into 2 groups on the basis of incisor retroclination: Group I composed of 48 CII/2 with retroclination exclusively of both maxillary central incisors; Group II composed of 67 CII/2 with retroclination of all four maxillary incisors. Using the initial orthodontic records, it was determined for each patient the presence of the following DDAs: tooth impaction, tooth agenesis, maxillary lateral incisor microdontia, tooth transpositions and supernumerary teeth. Results: 55.0% of patients were diagnosed with at least one of the DDAs studied. In the total sample the prevalence rates were determined as follows: 20.0% of palatal maxillary canine impaction, 27.4% of third molar agenesis, and 15.7% of maxillary lateral incisor microdontia. No patient exhibited any transpositions or supernumerary teeth. The distribution of the DDAs studied by groups revealed a strong association of palatal canine impaction, tooth agenesis and maxillary lateral incisor microdontia with Groups II but not with Group I. Conclusion: The association of DDAs with CII/2 malocclusion is not common to all types of maxillary incisor retroclination, suggesting different etiologic bases among the different manifestations of CII/2 malocclusion incisor retroclination."