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Mastites ovinas subclínicas por Staphylococcus aureus – eficácia da tilmicosina via parenteral
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Abstract(s)
Staphylococcus aureus é um dos principais agentes etiológicos de mastite em pequenos
ruminantes, provocando frequentemente casos graves de mastite gangrenosa muitas vezes
letal. As estratégias terapêuticas para fazer face a este agente etiológico, apresentam muitas
falhas em parte devido à biologia e fatores de resistência do próprio microrganismo. O presente
estudo teve como objetivos caracterizar a infeção por S. aureus num rebanho de ovinos da
raça autóctone portuguesa Bordaleira Serra da Estrela e avaliar a eficácia do antibiótico
tilmicosina, administrado por via parenteral, no tratamento de mastites subclínicas por S.
aureus durante o período seco. Para o efeito foram colhidas aleatoriamente amostras de leite
de um grupo de ovelhas pertencentes a um único rebanho no início do período de secagem.
Estas amostras foram previamente sujeitas ao Teste Californiano de Mastites e posteriormente
seguiram para análise bacteriológica. Perante os resultados da primeira análise bacteriológica
foram constituídos cinco diferentes grupos de animais: positivos a S. aureus e não tratados
(G1), positivos a S. aureus e tratados à secagem com tilmicosina (G2), positivos a S. aureus
tratados à secagem e ao parto com tilmicosina (G3), negativos a S. aureus e tratados à
secagem com tilmicosina (G4) e negativos a S. aureus não tratados. (G5). O tratamento
consistiu na administração subcutânea de 600 mg de tilmicosina. A eficácia do tratamento
instituído foi aferida através de uma nova análise bacteriológica e complementada pelo Teste
Californiano de Mastites realizada aos animais após o desmame dos borregos. Pôde concluirse
através deste estudo que a cura bacteriológica foi superior nos animais tratados com
tilmicosina (grupos G2 e G3) relativamente ao grupo não tratado (G1), não tendo sido
encontrada diferença entre os dois grupos tratados. Desta forma pode assim afirmar-se que a
administração parenteral de tilmicosina no período seco é uma estratégia terapêutica
promissora na cura de mastites por S. aureus em ovinos.
Staphylococcus aureus is the main etiological agent of small ruminants mastitis and is responsible for gangrenous mastitis cases that can be many times lethal. The therapeutic strategies aren’t effective because of the agent biology and resistance factors. The aim of this study was to characterize S. aureus infection in a flock of Bordaleira Serra da Estrela, a typical Portuguese sheep bread, and evaluate the efficacy of parenteral administration of tilmicosine in the dry period treatment in S. aureus subclinical mastitis. For that purpose milk samples were collected in the beginning of the dry period of a sheep group of one only and single flock. California Mastitis Test were done to all samples and then went to laboratory to bacteriological analysis. With the first tests, the first group were divided in other five groups: S. aureus positive and not treated animals (G1), S. aureus positive and tilmicosine dry-off treated animals (G2), S. aureus positive and tilmicosine dry-off and calving treatment animals (G3), S. aureus negative tilmicosine dry-off treatment animals (G4), and S. aureus negative not treated (G5). The treatment consisted in 600 mg tilmicosine subcutaneous administration of a commercial product. The treatment efficacy was evaluated by a second bacteriology analysis and California Mastitis Test after the lambing process. The treated animals (G2 and G3) had a higher rate cure than untreated animals (G1), without differences between one or two treatments. For that it can be said that the dry off treatment with parenteral tilmicosine administration is a promising therapeutic strategy against sheep S. aureus subclinical mastitis.
Staphylococcus aureus is the main etiological agent of small ruminants mastitis and is responsible for gangrenous mastitis cases that can be many times lethal. The therapeutic strategies aren’t effective because of the agent biology and resistance factors. The aim of this study was to characterize S. aureus infection in a flock of Bordaleira Serra da Estrela, a typical Portuguese sheep bread, and evaluate the efficacy of parenteral administration of tilmicosine in the dry period treatment in S. aureus subclinical mastitis. For that purpose milk samples were collected in the beginning of the dry period of a sheep group of one only and single flock. California Mastitis Test were done to all samples and then went to laboratory to bacteriological analysis. With the first tests, the first group were divided in other five groups: S. aureus positive and not treated animals (G1), S. aureus positive and tilmicosine dry-off treated animals (G2), S. aureus positive and tilmicosine dry-off and calving treatment animals (G3), S. aureus negative tilmicosine dry-off treatment animals (G4), and S. aureus negative not treated (G5). The treatment consisted in 600 mg tilmicosine subcutaneous administration of a commercial product. The treatment efficacy was evaluated by a second bacteriology analysis and California Mastitis Test after the lambing process. The treated animals (G2 and G3) had a higher rate cure than untreated animals (G1), without differences between one or two treatments. For that it can be said that the dry off treatment with parenteral tilmicosine administration is a promising therapeutic strategy against sheep S. aureus subclinical mastitis.
Description
Keywords
S. aureus Mastite Ovinos Tilmicosina Período seco Mastitis Sheep Tilmicosine Dry period