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Evidence for loss and reacquisition of alcoholic fermentation in a fructophilic yeast lineage

2018-04Journal article Open access
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dc.contributor.authorGonçalves, Carla
dc.contributor.authorWisecaver, Jennifer H.
dc.contributor.authorKominek, Jacek
dc.contributor.authorOom, Madalena Salema
dc.contributor.authorLeandro, Maria José
dc.contributor.authorShen, Xing-Xing
dc.contributor.authorOpulente, Dana A.
dc.contributor.authorZhou, Xiaofan
dc.contributor.authorPeris, David
dc.contributor.authorKurtzman, Cletus P.
dc.contributor.authorHittinger, Chris Todd
dc.contributor.authorRokas, Antonis
dc.contributor.authorGonçalves, Paula
dc.date.accessioned2019-12-16T15:52:04Z
dc.date.available2019-12-16T15:52:04Z
dc.date.issued2018-04
dc.description.abstractFructophily is a rare trait that consists of the preference for fructose over other carbon sources. Here, we show that in a yeast lineage (the Wickerhamiella/Starmerella, W/S clade) comprised of fructophilic species thriving in the high-sugar floral niche, the acquisition of fructophily is concurrent with a wider remodeling of central carbon metabolism. Coupling comparative genomics with biochemical and genetic approaches, we gathered ample evidence for the loss of alcoholic fermentation in an ancestor of the W/S clade and subsequent reinstatement through either horizontal acquisition of homologous bacterial genes or modification of a pre-existing yeast gene. An enzyme required for sucrose assimilation was also acquired from bacteria, suggesting that the genetic novelties identified in the W/S clade may be related to adaptation to the high-sugar environment. This work shows how even central carbon metabolism can be remodeled by a surge of HGT events.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGonçalves et al. eLife 2018;7:e33034. DOI: https://doi.org/10.7554/eLife.33034pt_PT
dc.identifier.doi10.7554/eLife.33034pt_PT
dc.identifier.issn2050-084X
dc.identifier.urihttp://hdl.handle.net/10400.26/30510
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publishereLife Sciences Publicationspt_PT
dc.relation.publisherversionhttps://doi.org/10.7554/eLife.33034pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectTarmerellapt_PT
dc.subjectAlcoholic fermentationpt_PT
dc.subjectEvolutionary biologypt_PT
dc.subjectFloral nichept_PT
dc.subjectFructophilic yeastspt_PT
dc.subjectGenomicspt_PT
dc.subjectHorizontal gene transferpt_PT
dc.subjectSugar metabolismpt_PT
dc.titleEvidence for loss and reacquisition of alcoholic fermentation in a fructophilic yeast lineagept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPagee33034pt_PT
oaire.citation.titleeLifept_PT
oaire.citation.volume7pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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