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A Electroquimioterapia no Tratamento dos Carcinomas Cutâneos de Células Escamosas nos Gatos
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Abstract(s)
Os carcinomas de células escamosas representam uma proporção significativa das neoplasias felinas,
especialmente os tumores cutâneos, sobretudo nos gatos de pelagem clara, que são mais sensíveis à
luz solar. O diagnóstico baseia-se na observação macroscópica das lesões e na análise citológica ou
histopatológica dos tecidos recolhidos por biópsia. Na maior parte dos casos, as lesões estão
presentes há várias semanas ou meses, pelo que são diagnosticadas numa fase avançada, o que torna
o tratamento mais complexo. A electroquimioterapia é uma técnica que combina o princípio da
electroporação das membranas celulares com a administração de quimioterapia, por via intravenosa
ou via intratumoral, para otimizar a destruição das células neoplásicas e que se tem revelado como
uma modalidade terapêutica eficaz no tratamento desta doença.
O objetivo deste trabalho foi analisar a literatura científica existente para determinar a eficácia e
segurança do tratamento de electroquimioterapia nos carcinomas cutâneos de células escamosas em
gatos.
Squamous cell carcinomas represent a significant proportion of feline neoplasms, especially of the skin, particularly in cats with light-color coats, which are more sensitive to sunlight. Diagnosis is based on macroscopic observation of the lesions and cytological or histopathological analysis of biopsied tissues. In most cases, the lesions have been present for several weeks or months, and are diagnosed at an advanced stage, which makes treatment more complex. Electrochemotherapy is a technique that combines the principle of electroporation of cell membranes with the administration of chemotherapy, either intravenously or intratumorally, to optimize the destruction of neoplastic cells, and which has proven to be an effective therapeutic modality in the treatment of this disease. The aim of this study was to analyze the existing scientific literature to determine the efficacy and safety of electrochemotherapeutic treatment in cutaneous squamous cell carcinomas in cats.
Squamous cell carcinomas represent a significant proportion of feline neoplasms, especially of the skin, particularly in cats with light-color coats, which are more sensitive to sunlight. Diagnosis is based on macroscopic observation of the lesions and cytological or histopathological analysis of biopsied tissues. In most cases, the lesions have been present for several weeks or months, and are diagnosed at an advanced stage, which makes treatment more complex. Electrochemotherapy is a technique that combines the principle of electroporation of cell membranes with the administration of chemotherapy, either intravenously or intratumorally, to optimize the destruction of neoplastic cells, and which has proven to be an effective therapeutic modality in the treatment of this disease. The aim of this study was to analyze the existing scientific literature to determine the efficacy and safety of electrochemotherapeutic treatment in cutaneous squamous cell carcinomas in cats.
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Keywords
Carcinomas cutâneos de células escamosas Eletroporação Eletroquimioterapia Gato Cutaneous squamous cell carcinoma Electroporation Electrochemotherapy Feline