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Genomic epidemiological analysis of Klebsiella pneumoniae from Portuguese hospitals reveals insights into circulating antimicrobial resistance

2022-08Contributo em revista Acesso aberto
http://hdl.handle.net/10400.26/59709
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Autores

Spadar, Anton
Phelan, Jody
Elias, Rita
Modesto, Ana
Caneiras, Cátia
Marques, Cátia
Lito, Luís
Pinto, Margarida
Cavaco-Silva, Patrícia
Ferreira, Helena

Orientador(es)

Resumo(s)

Klebsiella pneumoniae (Kp) bacteria are an increasing threat to public health and represent one of the most concerning pathogens involved in life-threatening infections and antimicrobial resistance (AMR). To understand the epidemiology of AMR of Kp in Portugal, we analysed whole genome sequencing, susceptibility testing and other meta data on 509 isolates collected nationwide from 16 hospitals and environmental settings between years 1980 and 2019. Predominant sequence types (STs) included ST15 (n = 161, 32%), ST147 (n = 36, 7%), ST14 (n = 26, 5%) or ST13 (n = 26, 5%), while 31% of isolates belonged to STs with fewer than 10 isolates. AMR testing revealed widespread resistance to aminoglycosides, fluoroquinolones, cephalosporins and carbapenems. The most common carbapenemase gene was blaKPC-3. Whilst the distribution of AMR linked plasmids appears uncorrelated with ST, their frequency has changed over time. Before year 2010, the dominant plasmid group was associated with the extended spectrum beta-lactamase gene blaCTX-M-15, but this group appears to have been displaced by another carrying the blaKPC-3 gene. Co-carriage of blaCTX-M and blaKPC-3 was uncommon. Our results from the largest genomics study of Kp in Portugal highlight the active transmission of strains with AMR genes and provide a baseline set of variants for future resistance monitoring and epidemiological studies.

Descrição

Palavras-chave

Antibiotics Antimicrobial resistance Bacterial genomics

URI

http://hdl.handle.net/10400.26/59709

Contexto Educativo

Citação

Spadar, A., Phelan, J., Elias, R. et al. Genomic epidemiological analysis of Klebsiella pneumoniae from Portuguese hospitals reveals insights into circulating antimicrobial resistance. Sci Rep 12, 13791 (2022). https://doi.org/10.1038/s41598-022-17996-1

Projetos de investigação

Unidades organizacionais

Fascículo

Editora

Springer Nature

DOI

10.1038/s41598-022-17996-1

Coleções

EM - Artigos Científicos

Licença CC

cclicense-by

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