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Long-term endoscopic gastrostomy enteral feeding of neurosurgical patients : a reference center experience

2025-07Contributo em revista Acesso aberto
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datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorPalma, Carolina
dc.contributor.authorSantos, Carla Adriana
dc.contributor.authorMendes, Ivo
dc.contributor.authorVara-Luiz, Francisco
dc.contributor.authorNunes, Gonçalo
dc.contributor.authorMocanu, Irina
dc.contributor.authorOliveira, Cátia
dc.contributor.authorMeira, Tânia
dc.contributor.authorBrito, Marta
dc.contributor.authorSantos, Ana Paula
dc.contributor.authorGonçalves, Ana Sofia
dc.contributor.authorCasimiro, Carlos
dc.contributor.authorSá, Manuel Cunha e
dc.contributor.authorFonseca, Jorge
dc.date.accessioned2026-05-13T11:57:31Z
dc.date.available2026-05-13T11:57:31Z
dc.date.issued2025-07
dc.description.abstractBackground/Objectives: Nutritional support in neurosurgical patients is challenging due to severe brain injury, neurological disease, or post-surgical complications. This study aimed to assess outcomes of long-term enteral nutrition via endoscopic gastrostomy (PEG) in these patients over a 22-year period. Methods: A single-center retrospective (2001–2023) study was conducted on patients referred for PEG. Included patients presented severe traumatic brain injury (TBI), stroke, brain tumor, or other neurosurgical conditions. Demographic, anthropometric, and clinical data were collected. Results: A total of 196 patients were included (105 men); 57% were under 65 years. The main diagnoses were stroke (41.8%), TBI (35.2%), and brain tumors (19.9%). The median time from diagnosis to PEG was 94 days. At the time of PEG, only 38.5% were underweight. Outcomes: A total of 132 deaths (75.4%) occurred, while 21 patients resumed oral feeding (10.7%), 22 patients remained PEG-fed (12.6%), and 21 patients were lost to follow-up (10.7%). Most surviving PEG-fed patients had experienced stroke (77%). Median post-PEG survival was 11.5 months and 88% survived >1 month. Higher albumin, transferrin, and cholesterol levels at the time of PEG were associated with longer survival. Albumin (p < 0.001) and transferrin (p < 0.01) were significantly associated with reduced short-term mortality. Conclusions: Despite limited overall survival, reflecting the clinical severity of the diseases, most patients were adequate survivors, and PEG-feeding proved to be appropriate and useful for neurosurgical patients. While most patients had normal-to-high BMI, low serum biomarkers reflected acute illness. Higher serum albumin level was associated with better outcomes, supporting its potential prognostic value.eng
dc.identifier.citationPalma C, Santos CA, Mendes I, Vara-Luiz F, Nunes G, Mocanu I, Oliveira C, Meira T, Brito M, Santos AP, et al. Long-Term Endoscopic Gastrostomy Enteral Feeding of Neurosurgical Patients: A Reference Center Experience. Biomedicines. 2025; 13(7):1549. https://doi.org/10.3390/biomedicines13071549
dc.identifier.doi10.3390/biomedicines13071549
dc.identifier.issn2227-9059
dc.identifier.urihttp://hdl.handle.net/10400.26/63105
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relation.hasversionhttps://doi.org/10.3390/biomedicines13071549
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectpercutaneous endoscopic gastrostomy
dc.subjectPEG
dc.subjectneurosurgery
dc.subjectdysphagia
dc.subjecttube feeding
dc.subjectenteral nutrition
dc.subjecttraumatic brain inhury
dc.subjectbrain tumor
dc.titleLong-term endoscopic gastrostomy enteral feeding of neurosurgical patients : a reference center experienceeng
dc.typecontribution to journal
dspace.entity.typePublication
oaire.citation.issue7
oaire.citation.startPage1549
oaire.citation.titleBiomedicines
oaire.citation.volume13
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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