Loading...
Publication
Estratégias de formulação e dispensa em geriatria
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 1.51 MB | Adobe PDF |
Authors
Advisor(s)
Abstract(s)
Os idosos fazem parte de um segmento populacional cujo crescimento é bastante elevado em termos globais, ao qual Portugal não é exceção, constituindo um desafio significante para as autoridades de saúde e indústria farmacêutica, pois o avançar da idade traz várias comorbilidades e alterações do foro fisiológico e patológico, que requerem especial atenção.
Existem várias razões que influenciam a falta de adesão a terapêutica, uma delas é a inadequação das formulações às necessidades do doente. Isto pode conduzir ao não cumprimento da terapêutica farmacológica prescrita pelo médico, levando a deterioração do estado de saúde do doente e, consequentemente, mais gastos para o sistema nacional de saúde, podendo ainda contribuir para o incremento da polifarmácia.
Daí a importância do desenvolvimento de abordagens de personalização da medicação; a ideia de “one size fits all” já não se aplica, pelo que se deve ter em consideração na conceção das formulações as necessidades dos subgrupos a que os medicamentos se destinam. Para isso, a indústria farmacêutica deve utilizar as tecnologias de fabrico avançadas, para produzir formas farmacêuticas convenientes e armazenadas em material de acondicionamento de fácil utilização. Nesta perspetiva, enquadra-se o desenvolvimento de formulações orodispersíveis e, mais recentemente, a impressão tridimensional de medicamentos, ainda numa fase inicial.
Esta revisão reporta os recentes avanços, os produtos e serviços existentes e formas farmacêuticas adaptadas ao doente geriátrico.
Overall, the elderly is part of a population segment whose growth is quite high to which Portugal is no exception, constituting a significant challenge for health authorities and the pharmaceutical industry because advancing age brings various comorbidities and physiological and pathological changes, which require special attention. There are several reasons influencing the lack of compliance to therapy, one of which is the unsuitability of the formulations to the patient's needs. It may lead to non-compliance with the pharmacological treatment prescribed by the doctor, resulting in deterioration of the patient's health status and, consequently, more costs for the national health system, and may also contribute to increase polypharmacy. Hence the importance of developing approaches to personalization of medication; the idea of "one size fits all" no longer applies, so the sub-group needs for whom the drugs are intended must be taken into consideration when designing pharmaceutical formulations. To do this, the pharmaceutical industry must use advanced manufacturing technologies to produce convenient dosage forms stored in user-friendly packaging. In this perspective, the development of orodispersible formulations is an example, and more recently the application of 3D printing in the pharmaceutical field, which is still at an early stage. This review reports on recent advances, existing products and services and drug dosage forms adapted to the geriatric patien.
Overall, the elderly is part of a population segment whose growth is quite high to which Portugal is no exception, constituting a significant challenge for health authorities and the pharmaceutical industry because advancing age brings various comorbidities and physiological and pathological changes, which require special attention. There are several reasons influencing the lack of compliance to therapy, one of which is the unsuitability of the formulations to the patient's needs. It may lead to non-compliance with the pharmacological treatment prescribed by the doctor, resulting in deterioration of the patient's health status and, consequently, more costs for the national health system, and may also contribute to increase polypharmacy. Hence the importance of developing approaches to personalization of medication; the idea of "one size fits all" no longer applies, so the sub-group needs for whom the drugs are intended must be taken into consideration when designing pharmaceutical formulations. To do this, the pharmaceutical industry must use advanced manufacturing technologies to produce convenient dosage forms stored in user-friendly packaging. In this perspective, the development of orodispersible formulations is an example, and more recently the application of 3D printing in the pharmaceutical field, which is still at an early stage. This review reports on recent advances, existing products and services and drug dosage forms adapted to the geriatric patien.
Description
Dissertação para obtenção do grau de Mestre no Instituto Universitário Egas Moniz
Keywords
Geriatria Personalização da medicação Design centrado no doente Impressão 3D