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Boosting cosmeceutical peptides : coupling Imidazolium-based ionic liquids to pentapeptide-4 originates new leads with antimicrobial and collagenesis-inducing activities

2022-07Contributo em revista Acesso aberto
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datacite.subject.fosCiências Médicas
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorGomes, Ana
dc.contributor.authorBessa, Lucinda J.
dc.contributor.authorFernandes, Iva
dc.contributor.authorAguiar, Luísa
dc.contributor.authorFerraz, Ricardo
dc.contributor.authorMonteiro, Cláudia
dc.contributor.authorMartins, M. Cristina L.
dc.contributor.authorMateus, Nuno
dc.contributor.authorGameiro, Paula
dc.contributor.authorTeixeira, Cátia
dc.contributor.authorGomes, Paula
dc.date.accessioned2025-11-03T16:53:50Z
dc.date.available2025-11-03T16:53:50Z
dc.date.issued2022-07
dc.description.abstractFollowing our previous reports on dual-action antibacterial and collagenesis-inducing hybrid peptide constructs based on “pentapeptide-4” (PP4, with amino acid sequence KTTKS), whose N-palmitoyl derivative is the well-known cosmeceutical ingredient Matrixyl, herein we disclose novel ionic liquid/PP4 conjugates (IL-KTTKS). These conjugates present potent activity against either antibiotic-susceptible strains or multidrug resistant clinical isolates of both Gram-positive and Gram-negative bacterial species belonging to the so-called “ESKAPE” group of pathogens. Noteworthy, their antibacterial activity is preserved in simulated wound fluid, which anticipates an effective action in the setting of a real wound bed. Moreover, their collagenesis-inducing effects in vitro are comparable to or stronger than those of Matrixyl. Altogether, IL-KTTKS exert a triple antibacterial, antifungal, and collagenesis-inducing action in vitro. These findings provide solid grounds for us to advance IL-KTTKS conjugates as promising leads for future development of topical treatments for complicated skin and soft tissue infections (cSSTI). Further studies are envisaged to incorporate IL-conjugates into suitable nanoformulations, to reduce toxicity and/or improve resistance to proteolytic degradation.eng
dc.identifier.citationGomes A, Bessa LJ,Fernandes I, Aguiar L, Ferraz R,Monteiro C,Martins MCL,,Mateus N, Gameiro P, Teixeira C, Gomes P. 2022. Boosting Cosmeceutical Peptides: Coupling Imidazolium-Based Ionic Liquids to Pentapeptide-4 Originates New Leads with Antimicrobial and Collagenesis-Inducing Activities. Microbiol Spectr 10:e02291-21. https://doi.org/10.1128/spectrum.02291-21
dc.identifier.doi10.1128/spectrum.02291-21
dc.identifier.issn2165-0497
dc.identifier.urihttp://hdl.handle.net/10400.26/59497
dc.language.isoeng
dc.peerreviewedyes
dc.publisherAmerican Society for Microbiology
dc.relation.hasversionhttps://doi.org/10.1128/spectrum.02291-21
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectantibacterial
dc.subjectantifungal
dc.subjectcollagenesis-induction
dc.subjectcosmeceutical peptides
dc.subjectionic liquid
dc.subjectMatrixyl
dc.subjectantimicrobial activity
dc.subjectcollagen boosting
dc.subjectpentapeptide-4
dc.titleBoosting cosmeceutical peptides : coupling Imidazolium-based ionic liquids to pentapeptide-4 originates new leads with antimicrobial and collagenesis-inducing activitieseng
dc.typecontribution to journal
dspace.entity.typePublication
oaire.citation.startPagee02291-21
oaire.citation.titleMicrobiology Spectrum
oaire.citation.volume10
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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