Boosting cosmeceutical peptides : coupling Imidazolium-based ionic liquids to pentapeptide-4 originates new leads with antimicrobial and collagenesis-inducing activities

Following our previous reports on dual-action antibacterial and collagenesis-inducing hybrid peptide constructs based on “pentapeptide-4” (PP4, with amino acid sequence KTTKS), whose N-palmitoyl derivative is the well-known cosmeceutical ingredient Matrixyl, herein we disclose novel ionic liquid/PP4 conjugates (IL-KTTKS). These conjugates present potent activity against either antibiotic-susceptible strains or multidrug resistant clinical isolates of both Gram-positive and Gram-negative bacterial species belonging to the so-called “ESKAPE” group of pathogens. Noteworthy, their antibacterial activity is preserved in simulated wound fluid, which anticipates an effective action in the setting of a real wound bed. Moreover, their collagenesis-inducing effects in vitro are comparable to or stronger than those of Matrixyl. Altogether, IL-KTTKS exert a triple antibacterial, antifungal, and collagenesis-inducing action in vitro. These findings provide solid grounds for us to advance IL-KTTKS conjugates as promising leads for future development of topical treatments for complicated skin and soft tissue infections (cSSTI). Further studies are envisaged to incorporate IL-conjugates into suitable nanoformulations, to reduce toxicity and/or improve resistance to proteolytic degradation.

Palavras-chave

antibacterial antifungal collagenesis-induction cosmeceutical peptides ionic liquid Matrixyl antimicrobial activity collagen boosting pentapeptide-4

URI

http://hdl.handle.net/10400.26/59497

Citação

Gomes A, Bessa LJ,Fernandes I, Aguiar L, Ferraz R,Monteiro C,Martins MCL,,Mateus N, Gameiro P, Teixeira C, Gomes P. 2022. Boosting Cosmeceutical Peptides: Coupling Imidazolium-Based Ionic Liquids to Pentapeptide-4 Originates New Leads with Antimicrobial and Collagenesis-Inducing Activities. Microbiol Spectr 10:e02291-21. https://doi.org/10.1128/spectrum.02291-21

Editora

American Society for Microbiology

DOI

10.1128/spectrum.02291-21

Coleções

EM - Artigos Científicos

Licença CC

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