Development of Nevirapine resistance in children exposed to the prevention of mother-to-child HIV-1 transmission programme in Maputo, Mozambique

Antunes, Francisco; Zindoga, Pereira; Gomes, Perpétua; Augusto, Orvalho; Mahumane, Isabel; Veloso, Luís; Valadas, Emília; Camacho, Ricardo

http://hdl.handle.net/10400.26/14897

Use this identifier to reference this record.

Name:	Description:	Size:	Format:
Artigo04_PGomes_2016.pdf		359.29 KB	Adobe PDF	Download

Send Feedback

Authors

Abstract(s)

"Background: single-dose nevirapine (sd-NVP) has been the main option for prevention of mother-to-child transmission (PMTCT) of HIV-1 in low-resource settings. However, sd-NVP can induce the selection of HIV-1 resistant mutations in mothers and infants. In Mozambique, there are limited data regarding the profile of NVP resistance associated mutations (RAM) in the context of PMTCT. Objectives: to assess the prevalence and the factors associated with NVP RAM among children born to HIV-1 infected mothers enrolled in the PMTCT programme adopted in Mozambique."

Description

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Keywords

Single-dose nevirapine Mother-to-child transmission HIV-1 Mozambique NVP resistance

URI

http://hdl.handle.net/10400.26/14897

Citation

Antunes F, Zindoga P, Gomes P, Augusto O, Mahumane I, Veloso L, et al. (2015) Development of Nevirapine Resistance in Children Exposed to the Prevention of Mother-to-Child HIV-1 Transmission Programme in Maputo, Mozambique. PLoS ONE 10 (7): e0131994. doi:10.1371/journal.pone.0131994