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Transthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular Identities to Endothelial Cells

2013-11-01Journal article Open access
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dc.contributor.authorNunes, Raquel J.
dc.contributor.authorOliveira, Paula de
dc.contributor.authorLages, Ana
dc.contributor.authorBecker, Jörg D.
dc.contributor.authorMarcelino, Paulo
dc.contributor.authorBarroso, Eduardo
dc.contributor.authorPerdigoto, Rui
dc.contributor.authorKelly, Jeffery W.
dc.contributor.authorQuintas, Alexandre
dc.contributor.authorSantos, Susana C. R.
dc.date.accessioned2014-11-06T14:20:47Z
dc.date.available2014-11-06T14:20:47Z
dc.date.issued2013-11-01
dc.description"This research was originally published in The Journal of Biological Chemistry. Raquel J. Nunes, et al. Transthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular Identities to Endothelial Cells. Journal Name. 2013; 288:31752-31760. © the American Society for Biochemistry and Molecular Biology."
dc.description.abstract"Background: The biological effects of transthyretin proteins on vasculature remain unknown. Results: V30M transthyretin tetramer modulates endothelial global gene expression, down-regulating pro-angiogenic genes, inducing apoptosis and inhibiting migration. Conclusion: Transthyretin proteins regulate angiogenesis by conferring different molecular identities to endothelial cells. Significance: This work has critical implications in the prevention of early hepatic artery thrombosis in familial amyloidotic polyneuropathy patients after liver transplantation."por
dc.identifier.citationTHE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 288, NO. 44, pp. 31752–31760, November 1, 2013por
dc.identifier.doi10.1074/jbc.M113.469858
dc.identifier.issn0021-9258
dc.identifier.issne-1083-351X
dc.identifier.urihttp://hdl.handle.net/10400.26/6945
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherASBMBpor
dc.relation.publisherversionhttp://www.jbc.org/content/288/44/31752por
dc.subjectAngiogenesispor
dc.subjectEndothelial Cellpor
dc.subjectFamilial Amyloidotic Polyneuropathypor
dc.subjectGene Expressionpor
dc.subjectMicroarraypor
dc.subjectTransthyretinpor
dc.subjectVascular Biologypor
dc.titleTransthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular Identities to Endothelial Cellspor
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5646-ICCMS/PIC%2FIC%2F83062%2F2007/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F43482%2F2008/PT
oaire.citation.endPage31760por
oaire.citation.startPage31752por
oaire.citation.titleJournal of Biological Chemistrypor
oaire.citation.volume288por
oaire.fundingStream5646-ICCMS
oaire.fundingStreamSFRH
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isProjectOfPublicationded0ef8f-3a16-4abf-9c9b-4408174497c4
relation.isProjectOfPublication62b7722d-5784-4591-9174-84190d78975b
relation.isProjectOfPublication.latestForDiscoveryded0ef8f-3a16-4abf-9c9b-4408174497c4

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