Transthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular Identities to Endothelial Cells

"Background: The biological effects of transthyretin proteins on vasculature remain unknown. Results: V30M transthyretin tetramer modulates endothelial global gene expression, down-regulating pro-angiogenic genes, inducing apoptosis and inhibiting migration. Conclusion: Transthyretin proteins regulate angiogenesis by conferring different molecular identities to endothelial cells. Significance: This work has critical implications in the prevention of early hepatic artery thrombosis in familial amyloidotic polyneuropathy patients after liver transplantation."

Descrição

"This research was originally published in The Journal of Biological Chemistry. Raquel J. Nunes, et al. Transthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular Identities to Endothelial Cells. Journal Name. 2013; 288:31752-31760. © the American Society for Biochemistry and Molecular Biology."