Publicação
Vascular function after acute aerobic exercise in adults with and without type 2 diabetes mellitus
| datacite.subject.fos | Ciências Médicas::Ciências da Saúde | |
| datacite.subject.sdg | 03:Saúde de Qualidade | |
| dc.contributor.author | Marôco, João Luís | |
| dc.contributor.author | Arrais, Inês | |
| dc.contributor.author | Silvestre, Tiago | |
| dc.contributor.author | Pinto, Marco | |
| dc.contributor.author | Laranjo, Sérgio | |
| dc.contributor.author | Magalhães, João | |
| dc.contributor.author | Santa-Clara, Helena | |
| dc.contributor.author | Fernhall, Bo | |
| dc.contributor.author | Melo, Xavier | |
| dc.date.accessioned | 2026-06-01T11:00:45Z | |
| dc.date.available | 2026-06-01T11:00:45Z | |
| dc.date.issued | 2025-07 | |
| dc.description.abstract | It is unknown whether type 2 diabetes mellitus (T2DM) influences the vascular function response to aerobic exercise. We examined brachial artery flow-mediated dilation (FMD) and flow-mediated slowing (FMS) of pulse wave velocity (PWV), 10-and 60-min after a high-intensity interval exercise (HIIE) and moderate-intensity continuous exercise (MICE) in adults with and without T2DM. Twelve older male adults with T2DM (57–84 years), and twenty-four healthy young and older adults (12 per group, aged 20–40 years and 57–76 years, respectively), completed an acute bout of HIIE, MICE, and a non-exercise condition. FMD was evaluated by the same researcher following standardized guidelines. FMS was calculated from the manufacturer’s PWV beta formulas. Central arterial stiffness was estimated via carotid-femoral PWV (cfPWV). %FMD was reduced (d= − 5.94%, 95% CI: − 10.50 to − 1.38%, p = 0.002), whereas %FMS increased (d = 4.55%, 95% CI: 0.62 to 8.48%, p = 0.01), 10-min after HIIE only in adults with T2DM, normalizing 60-min into recovery. Conversely, %FMD was increased (d = 5.33%, 95% CI: 0.76 to 9.89%, p = 0.009) 10-min after MICE only in adults with T2DM. cfPWV remained unchanged following HIIE and MICE in all groups. We report disease-associated vascular function responses to aerobic exercise suggesting both HIIE and MICE uncover transient vascular alterations in older adults with T2DM. | eng |
| dc.identifier.citation | Marôco, J.L., Arrais, I., Silvestre, T. et al. Vascular function after acute aerobic exercise in adults with and without type 2 diabetes mellitus. Sci Rep 15, 25727 (2025). https://doi.org/10.1038/s41598-025-10865-7 | |
| dc.identifier.doi | 10.1038/s41598-025-10865-7 | |
| dc.identifier.issn | 2045-2322 | |
| dc.identifier.uri | http://hdl.handle.net/10400.26/63445 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.publisher | Springer Nature | |
| dc.relation.hasversion | https://doi.org/10.1038/s41598-025-10865-7 | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | Cardiovascular biology | |
| dc.subject | Type 2 diabetes | |
| dc.subject | acute aerobic exercise | |
| dc.subject | adults | |
| dc.title | Vascular function after acute aerobic exercise in adults with and without type 2 diabetes mellitus | eng |
| dc.type | contribution to journal | |
| dspace.entity.type | Publication | |
| oaire.citation.startPage | 25727 | |
| oaire.citation.title | Scientific Reports | |
| oaire.citation.volume | 15 | |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 |