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Publication
O Plasma Rico Em Plaquetas No Tratamento Da Osteoartrite Dos Equinos
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Advisor(s)
Abstract(s)
As patologias articulares, particularmente a osteoartrite,representam uma parte significativa nas
perdas de bem-estar e de performances nos equinos. Esta doença da cartilagem articular, de natureza
degenerativa, é altamente complexa e os tratamentos convencionais com anti-inflamatórios mostramse
insuficientes. No sentido de limitar a degenerescência precoce e a perda de função da articulação,
o interesse crescente pela medicina regenerativa tem levado a um aumento considerável de estudos
relativos ao Plasma rico em plaquetas e à sua utilização neste tipo de patologias. Graças a uma técnica
simples de colheita e dupla centrifugação e com um custo moderado, pode ser obtida uma solução
concentrada em plaquetas. Esta substância permite a liberação de fatores de crescimento e de
citoquinas diretamente no local da lesão. Os fatores de crescimento ajudam na proliferação celular, na
reparação dos tecidos e, consequentemente, na regeneração da cartilagem. Eles são suplementados
pelas citoquinas que são responsáveis pela regulação do catabolismo e da reação inflamatória intraarticular.
O alívio da dor e dos sinais clínicos permite alcançar retorno ao exercício ou aumento do
conforto na vida de muitos cavalos. Mesmo tendo em conta a variabilidade individual, este produto
autólogo apresenta resultados muito positivos e promissores no futuro da medicina veterinária. No
entanto, mais estudos são necessários para definir um consenso sobre protocolos de preparação e de
aplicação do Plasma Rico em Plaquetas, bem como para obter mais informação sobre a eficiência e a
fiabilidade do tratamento.
Joint pathologies, particularly osteoarthritis , represent a significant portion of welfare and performance losses in horses. This degenerative joint disease is highly complex, and conventional treatments with anti-inflammatories often prove insufficient. In an effort to limit early degeneration and joint function loss, the growing interest in regenerative medicine has led to a considerable increase in studies regarding Platelets Rich Plasma and its use in such pathologies. Thanks to a simple technique of collection and double centrifugation, and with moderate cost, a platelet-rich plasma solution can be obtained. This substance allows for the release of growth factors and cytokines directly at the site of the lesion. The growth factors aid in cell proliferation, tissue repair, and consequently, cartilage regeneration. They are supplemented by cytokines responsible for regulating catabolism and the intraarticular inflammatory reaction. Relief from pain and clinical signs enables a return to exercise or an increase in the quality of life for many horses. Despite individual variability, this autologous product shows very positive and promising results for the future of veterinary medicine. However, further studies are needed to establish a consensus on Platelets Rich Plasma preparation and application protocols, as well as to obtain more information on treatment efficiency and reliability.
Joint pathologies, particularly osteoarthritis , represent a significant portion of welfare and performance losses in horses. This degenerative joint disease is highly complex, and conventional treatments with anti-inflammatories often prove insufficient. In an effort to limit early degeneration and joint function loss, the growing interest in regenerative medicine has led to a considerable increase in studies regarding Platelets Rich Plasma and its use in such pathologies. Thanks to a simple technique of collection and double centrifugation, and with moderate cost, a platelet-rich plasma solution can be obtained. This substance allows for the release of growth factors and cytokines directly at the site of the lesion. The growth factors aid in cell proliferation, tissue repair, and consequently, cartilage regeneration. They are supplemented by cytokines responsible for regulating catabolism and the intraarticular inflammatory reaction. Relief from pain and clinical signs enables a return to exercise or an increase in the quality of life for many horses. Despite individual variability, this autologous product shows very positive and promising results for the future of veterinary medicine. However, further studies are needed to establish a consensus on Platelets Rich Plasma preparation and application protocols, as well as to obtain more information on treatment efficiency and reliability.
Description
Keywords
Plasma Rico Em Plaquetas PRP Medicina Regenerativa Articulação Cartilagem Cavalos Osteoartrite Platelet Rich Plasma Regenerative Medicine Joint Cartilage Horses Osteoarthritis