Publicação
Bar adsorptive microextraction for trace determination of natural and semi-synthetic cannabinoids in saliva
| datacite.subject.fos | Ciências Naturais::Ciências Químicas | |
| datacite.subject.sdg | 03:Saúde de Qualidade | |
| datacite.subject.sdg | 16:Paz, Justiça e Instituições Eficazes | |
| dc.contributor.author | Pereira, Maria Beatriz | |
| dc.contributor.author | Sá, Joana M. N. | |
| dc.contributor.author | Justino, Gonçalo C. | |
| dc.contributor.author | Quintas, Alexandre | |
| dc.contributor.author | Neng, Nuno R. | |
| dc.date.accessioned | 2026-07-01T11:02:34Z | |
| dc.date.available | 2026-07-01T11:02:34Z | |
| dc.date.issued | 2026-05 | |
| dc.description.abstract | Cannabis is the most widely consumed illicit substance worldwide, and the rise of synthetic and semi-synthetic cannabinoids poses growing public health concerns due to their high potency and unpredictable effects. This study presents a new analytical methodology for the simultaneous determination of natural and semi-synthetic cannabinoids (cannabidiol (CDB), Δ8-tetrahydrocannabinol (∆8-THC), Δ9-tetrahydrocannabinol (∆9-THC), and hexahydrocannabinol (HHC)) in saliva using gas chromatography coupled with mass spectrometry (GC-MS) in combination with bar adsorptive microextraction (BAμE) as a green sample preparation. The optimized method showed satisfactory recoveries (57.3–80.6%), low detection and quantification limits (1.25 and 4.13 ng/mL, respectively), excellent linearity (r2 ≥ 0.9963), and robust precision and accuracy. Application to authentic saliva samples demonstrated cannabinoid levels consistent with literature values. Overall, the proposed methodology offers a cost-effective, miniaturized, and environmentally sustainable platform for routine oral fluid cannabinoid analysis, highlighting its potential for forensic, clinical, and toxicological applications. | eng |
| dc.identifier.citation | Pereira MB, Sá JMN, Justino GC, Quintas A, Neng NR. Bar Adsorptive Microextraction for Trace Determination of Natural and Semi-Synthetic Cannabinoids in Saliva. Separations. 2026; 13(5):134. https://doi.org/10.3390/separations13050134 | |
| dc.identifier.doi | 10.3390/separations13050134 | |
| dc.identifier.issn | 2297-8739 | |
| dc.identifier.uri | http://hdl.handle.net/10400.26/63671 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.publisher | MDPI | |
| dc.relation.hasversion | https://doi.org/10.3390/separations13050134 | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | phytocannabinoid | |
| dc.subject | BAμE | |
| dc.subject | GC-MS | |
| dc.subject | biological samples | |
| dc.title | Bar adsorptive microextraction for trace determination of natural and semi-synthetic cannabinoids in saliva | eng |
| dc.type | contribution to journal | |
| dspace.entity.type | Publication | |
| oaire.citation.issue | 5 | |
| oaire.citation.startPage | 134 | |
| oaire.citation.title | Separations | |
| oaire.citation.volume | 13 | |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 |