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Orientador(es)
Resumo(s)
Cannabis is the most widely consumed illicit substance worldwide, and the rise of synthetic and semi-synthetic cannabinoids poses growing public health concerns due to their high potency and unpredictable effects. This study presents a new analytical methodology for the simultaneous determination of natural and semi-synthetic cannabinoids (cannabidiol (CDB), Δ8-tetrahydrocannabinol (∆8-THC), Δ9-tetrahydrocannabinol (∆9-THC), and hexahydrocannabinol (HHC)) in saliva using gas chromatography coupled with mass spectrometry (GC-MS) in combination with bar adsorptive microextraction (BAμE) as a green sample preparation. The optimized method showed satisfactory recoveries (57.3–80.6%), low detection and quantification limits (1.25 and 4.13 ng/mL, respectively), excellent linearity (r2 ≥ 0.9963), and robust precision and accuracy. Application to authentic saliva samples demonstrated cannabinoid levels consistent with literature values. Overall, the proposed methodology offers a cost-effective, miniaturized, and environmentally sustainable platform for routine oral fluid cannabinoid analysis, highlighting its potential for forensic, clinical, and toxicological applications.
Descrição
Palavras-chave
phytocannabinoid BAμE GC-MS biological samples
Contexto Educativo
Citação
Pereira MB, Sá JMN, Justino GC, Quintas A, Neng NR. Bar Adsorptive Microextraction for Trace Determination of Natural and Semi-Synthetic Cannabinoids in Saliva. Separations. 2026; 13(5):134. https://doi.org/10.3390/separations13050134
Editora
MDPI