Percorrer por data de Publicação, começado por "2026-05"
A mostrar 1 - 10 de 67
Resultados por página
Opções de ordenação
- Feasibility and acceptability of a self-management program for stroke survivors: a mixed-methods studyPublication . Pereira, Carla; Branco, Daniela; Branquinho, Inês; Dias, Teresa; Marques, António
- Feasibility and acceptability of a self-management program for stroke survivors: a mixed-methods studyPublication . Pereira, Carla; Branco, Daniela; Branquinho, Inês; Dias, Teresa; Marques, António
- Bone availability in the sagittal dimension of the infrazygomatic crest for miniscrew insertion : a retrospective cone-beam computed tomography studyPublication . Furão, Susana; Bugaighis, Iman; Proença, Luís; Brito, José; Costa, Hélder Nunes; Pereira, François Durand; Pereira, Pedro MarianoBackground: There is limited information available regarding the bone volume in the sagittal dimension of the infrazygomatic crest (IZC) that is safe for the insertion of a temporary skeletal anchorage device. The objective of this study was to assess the sagittal bone availability when the anterior and posterior walls of the IZC reach an inclination of 45°. Methods: A cross-sectional investigation was undertaken on 100 cone-beam computed tomography scans of 40 males and 60 females. A total of 20 landmarks were digitized for each IZC outline, 1 mm from the vestibular alveolar bone, and their x, y, and z coordinates were extracted. Afterward, the sagittal measurement of the IZC at which the curvature reached 45° was recorded. Symmetry of measurements was assessed using paired-samples t tests. In addition, these measurements were compared as a function of sex and age group (≤21 vs >21 years) using an independent-samples t test and the Spearman rank correlation coefficient test (P <0.05). Results: There were no significant differences between paired sagittal measurements of the IZC (3.5 ± 1.5 mm on the right side and 3.6 ± 1.3 mm on the left side; P = 0.144), except for younger patients (P = 0.030). In addition, no significant differences were found between corresponding male and female measurements (P ≥0.149). A significant discrepancy was identified between the younger age group (3.2 ± 1.2 mm) and the older cohort (3.8 ± 1.6 mm) for the sagittal dimension of the right IZC (P = 0.038), with an estimated mean difference of 0.03-1.16 mm (95% confidence interval). A significant positive weak correlation was found between the sagittal dimension of the right IZC and age (ρ = 0.201; P = 0.045). Conclusions: Sufficient IZC bone volume is available at an angle of 45° for inserting a temporary skeletal anchorage device, with no sex or side variation, except for the significantly greater sagittal dimension of the right IZC in older patients.
- Impact of Sarcopenia on prognosis, treatment toxicity and surgical complications in locally advanced gastric cancerPublication . Dias, David da Silva; Luz, Paulo; Fortuna, Ana; Águas, Ana; Machado, Mafalda; Gosálbez, Beatriz; Farate, Rosa; Pinho, Rita Clemente; Valente, Ana Carmo; Mendes, José Leão; Seladas, Marta Maria; Trabulo, Carolina; Ravasco, PaulaBackground: Weight loss and skeletal muscle wasting are frequent in cancer and may influence treatment tolerance and outcomes. Computed tomography (CT) based body composition analysis at the third lumbar vertebra (L3) is an accurate method to quantify skeletal muscle in routine oncology care. Methods: We performed a multicenter retrospective cohort study including 202 adults with locally advanced (stage IB–III) gastric cancer treated in four Portuguese hospitals (January 2020–December 2022). Skeletal muscle area (SMA) was assessed on baseline CT at the L3 vertebral level, using Data Analysis Facilitation Suite (DAFS) software v3.11.2, and skeletal muscle index (SMI) was subsequently calculated. Patients with low muscle quantity were classified as sarcopenic (below sex-specific SMI mean). We evaluated associations with relapse-free survival (RFS), overall survival (OS), FLOT chemotherapy dose-limiting toxicities (DLTs), and postoperative complications after gastrectomy. Results: Mean age was 69 years, 65% had ECOG PS 0, 53% received FLOT chemotherapy protocol. Mean SMI was 49.6 cm2/m2 in males and 40.9 cm2/m2 in females and correlated positively, though moderately, with BMI (p < 0.01; r = 0.424). Sarcopenia was not significantly associated with RFS (p = 0.186) or OS (p = 0.168) at 30-month follow-up. Although numerical differences were observed (64% vs. 56% of patients did not relapse and 74% vs. 63% were alive, for non-sarcopenic vs. sarcopenic patients). Sarcopenia was associated with a higher risk of DLTs (p = 0.021; OR 2.56, 95% CI 1.15–5.73) and postoperative complications (p = 0.024; OR 2.16, 95% CI 1.11–4.21). Conclusions: Sarcopenia significantly increases the risk of chemotherapy toxicity and postoperative complications in locally advanced gastric cancer. However, its effect on OS and RFS was not statistically significant at 30-month follow-up. Standardization of CT-based sarcopenia cut-offs remains a major barrier to clinical implementation.
- Orthographic knowledge as a predictor of writing composition in European Portuguese : a longitudinal study in grade 2Publication . Querido, Luís; Fernandes, Sandra; Verhaeghe, Arlette; Marques, CatarinaWriting development in the early grades depends critically on transcription skills, yet little is known about how components of orthographic knowledge support children’s written composition in European Portuguese. This study examined whether lexical and sublexical orthographic knowledge assessed at the beginning of Grade 2 predict written composition at the end of the school year, and whether these effects are direct or mediated by word spelling. Eighty Grade 2 children completed measures of lexical orthographic knowledge (orthographic choice), sublexical orthographic knowledge (orthographic awareness), and word spelling at the beginning of the year, and a written composition task scored for lexical diversity at year’s end. Path analyses with maximum likelihood estimation and bias-corrected bootstrapping showed that orthographic knowledge explained 44% of the variance in word spelling and up to 18% in written composition. Lexical orthographic knowledge was a significant direct predictor of written composition (β = 0.38, p < 0.01), whereas sublexical orthographic knowledge showed a small but significant indirect effect through spelling (β = 0.08, p < 0.05) in the full mediation model. These findings highlight the central role of orthographic knowledge, particularly its lexical component, in supporting early writing in an orthography of intermediate depth.
- Oral manifestations in HIV-positive individuals under highly active antiretroviral therapy : a systematic review and meta-analysis of prevalence dataPublication . Dagnoni, Thais Suzigan; Paranhos, Luiz Renato; Almeida, Vinícius Lima de; Vieira, Walbert de Andrade; Botelho, João; Netto, Verena Paula Stern; Silva, Micena Roberta Miranda Alves e; Franco, Ademir; Brito Júnior, Rui Barbosa deThis study aims to analytically explore the prevalence of oral manifestations in HIV-positive patients who are receiving or are not receiving highly active antiretroviral therapy (HAART). Electronic search was conducted at multiple databases (PubMed, Embase, LILACS, SciELO, Scopus and Web of Science) and gray literature was also assessed (ProQuest and EASY databases). JBI Critical Appraisal Tools were used to establish methodological quality. Data from each study was combined in a meta-analysis of proportions using an inverse variance method, Freeman-Tukey double arcsine transformation, and Clopper-Pearson confidence interval. Quality of evidence was determined via Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach. The search yielded 25 eligible articles, with quantitative synthesis from 13. Only four studies had a low risk of bias. The meta-analysis revealed a prevalence of oral manifestations in 42% (95% CI: 29% – 56%, I2 = 97%) of patients receiving HAART. Patients undergoing HAART were less likely to present oral manifestations (OR: 0.51; 95% CI: 0.27–0.94) than those in the non-HAART group, with a very low certainty of evidence. Although patients receiving HAART are less likely to present with oral manifestations, primary studies must be performed with a standardized methodology to guarantee results with a higher certainty of evidence.
- Post-market non-controlled study on the clinical safety of a synthetic calcium phosphate ceramic in alveolar bone regeneration : a 6-month prospective studyPublication . Silva, Nuno; Rodrigues, Carlota; Lobito, Angel; Azul, António Mano; Trancoso, Pedro Ferreira; Machado, Vanessa; Botelho, JoãoThis prospective, single-arm post-market study aimed to evaluate the clinical safety and performance of a synthetic calcium phosphate ceramic used in alveolar bone regeneration procedures. Eighty adult patients requiring bone augmentation were treated with β-tricalcium phosphate (β-TCP) under routine clinical indications. Surgical approaches were adapted to defect morphology. Safety outcomes included adverse events (AEs) and device deficiencies (DDs), while performance outcomes focused on two-dimensional radiographic bone assessment. Radiographic bone consolidation was defined as continuous trabecular radiopacity without radiolucent defects or clinical signs of infection. Patients were followed for six months post-surgery, with clinical and radiographic evaluations, as well as assessment of oral health-related quality of life (OHIP-14). All 80 patients (mean age: 47.2 ± 18.9 years; 51% male) completed the immediate postoperative assessment. Eleven DDs (granule loss) were observed postoperatively (13.8%) and no AEs. At six months, 71 patients (88.8%) completed follow-up. Radiographic bone repair was confirmed in all cases clinically observed and with follow-up X-ray (100%). No AEs or DDs reported (AE-free rate: 100%) at this follow-up. The median OHIP-14 score improved significantly at six months (p = 0.037), indicating better self-reported oral health. Given the observational design, absence of a control group, and partial reliance on non-radiographic follow-up, these findings should be interpreted with caution. Within these limitations, the synthetic calcium phosphate ceramic demonstrated a favorable short-term safety profile and apparent bidimensional radiographic signs of clinical performance under real-world conditions, rather than definitive evidence of effectiveness. Further controlled studies incorporating histological and volumetric analyses are warranted to confirm its regenerative potential.
- Non-surgical cosmetic treatment modalities for interdental papilla reconstruction “black triangles” : an evidence-based reviewPublication . Elhaj, Ayah; Shatta, Bashar; Nguyen, Sheila; Pereira, Inês Novo; Hassan, HaidarBackground: The interdental papilla plays a vital role in dental and facial aesthetics, as the loss of papilla manifests as unesthetic “black triangles”. In recent years, non-surgical approaches such as hyaluronic acid injections, autologous platelet concentrates, laser therapy, and microneedling with vitamin C have emerged as alternatives to technically demanding and unpredictable surgical reconstruction. Aim: To evaluate the effectiveness, patient satisfaction, and safety of cosmetic non-surgical treatment modalities for the correction of black triangles. Materials and Methods: A comprehensive literature search was conducted using the PubMed, Cochrane Library, Scopus, and Embase databases, from January 2013 to January 2024. All case series, cohort studies, and randomized controlled trials with relevant outcomes were included. The BestBETs methodology was used, and the risk of bias was assessed using the “Quality Assessment Tool for Quantitative Studies.” Results: A total of 19 human studies met the inclusion criteria. Of these, six studies were classified as level II evidence, while the remaining 13 were categorized as level III or level IV evidence. Based on level II evidence, hyaluronic acid injections were effective and safe for correcting the black triangles and improving the smile. Evidence on non-surgical modalities such as autologous platelet concentrates, photobiomodulation therapy, and microneedling with vitamin C remains limited. Based on level II to level IV evidence, these conservative treatments are recommended as clinically effective for filling black triangle spaces, demonstrating high patient satisfaction and minimal adverse events. Conclusion: Non-surgical cosmetic treatments offer a promising alternative for reconstructing interdental papilla deficiencies, with benefits including reduced complications and favorable aesthetic outcomes. However, the current evidence remains limited, and findings should be interpreted with caution. Further well-designed, standardized clinical trials are required to establish the effectiveness, long-term stability, and patient-centred outcomes of these interventions.
- Wearable technologies in occupational safety and health: a systematic review and a human-centered implementation modelPublication . Mendes, David; Terradillos, Elena; Navas, Helena V. G.; Costa, Olga; Matias, João; Soares, VanessaWearable technologies have emerged as promising tools for supporting Occupational Safety and Health through continuous and multimodal monitoring of physiological, biomechanical, and environmental risk factors. However, evidence regarding their real-world effectiveness and implementation remains fragmented. This study presents a systematic literature review conducted in accordance with PRISMA 2020 guidelines, synthesizing evidence from 60 studies addressing wearable-based monitoring, assessment, and intervention in occupational contexts. The review examines the types of technologies applied, the risks and functions addressed, the evidence on effectiveness, the evaluation metrics used, and the main barriers affecting implementation. The findings show that wearable technologies are mainly applied to ergonomic, physiological, environmental, and critical-event risks, using devices such as inertial sensors, biosensors, smart personal protective equipment, and exoskeletons. While the evidence indicates strong potential for real-time monitoring, risk detection, and data-informed decision-making, most studies rely on controlled or short-term evaluations, and consistent evidence of sustained accident reduction remains limited. The results also highlight technical, organizational, ethical, and human-related barriers, including usability, interoperability, privacy concerns, worker acceptance, and data governance. Based on this synthesis, a conceptual human-centered implementation model is proposed to support responsible and context-sensitive adoption.
- Pre-cure contact time and dentin surface roughness in modulating bonding and impregnation of self-adhesive composites to dentinPublication . Miranda, Inês; Sousa, Teresa Andrade e; Pereira, Pedro; Delgado, António H. S.Background: Self-adhesive flowable resin composites (SAFRCs) offer simplified, single-step placement and are intended to reduce technique sensitivity, but their bonding remains largely inconsistent. Therefore, this study investigated whether pre-cure contact time and dentin surface finish affect immediate bond strength and interfacial morphology of two commercial SAFRCs. Materials and methods: Sound human molars were allocated to 12 groups: two SAFRCs (Vertise™ Flow; Constic) × two finishes (fine vs. coarse diamond) × three pre-cure contact times (immediate/0 min, 1 min, 5 min). For positive controls a universal adhesive/conventional composite were applied. Three 2 × 2-mm cylinders/group were bonded to mid-coronal dentin discs and were light-cured (20 s; 950 mW/cm²) and tested in shear bond strength setup (SBS; 24 h at 1 mm/min). One fractured disc/group was examined by SEM and ~ 1-mm interface slices underwent Masson’s trichrome and were imaged at 100× with calibrated scaling. The 12 SAFRC groups were analyzed by three-way ANOVA with Tukey’s (α = 0.05); comparisons with the matched controls were performed separately using one-way ANOVA followed by Dunnett’s test. Results: Material (p = 0.02) and application time (p < 0.0001) significantly affected SBS; surface finish did not (p = 0.97). Five-minute pre-cure contact yielded the highest SBS for both SAFRCs and, in several groups, values not significantly different from the matched controls. SEM showed an application time-dependent improvement of the interface quality: with 0 min application showing no continuous interfacial resin/tubule tags; from 1 to 5 min, progressively continuous resin fronts with tags, most evident at 5 min, irrespective of finish. Masson’s trichrome revealed a more conspicuous dark-pink collagen band at the interface of immediate cure samples and attenuated/discontinuous after 1–5 min. Surface finish mainly altered interfacial contour without qualitative improvement. Conclusion: Prolonged pre-cure contact enhances SAFRC bonding; the tested roughness range was not determinative. Trichrome staining corroborates shallow demineralization with partially exposed collagen, indicating limited monomer infiltration and explaining the material-dependent, low bond efficacy of current SAFRCs.