A carregar...
Publicação
Insights into Candida colonization in intensive care unit patients : a prospective multicenter study
| Nome: | Descrição: | Tamanho: | Formato: | |
|---|---|---|---|---|
| 1.53 MB | Adobe PDF |
Orientador(es)
Resumo(s)
The skin mycobiota plays a significant role in infection risk, pathogen transmission, and personalized medicine approaches in intensive care settings. This prospective multicenter study aimed to enhance our understanding of intensive care units’ (ICUs’) Candida colonization dynamics, identify modifiable risk factors, and assess their impact on survival risk. Specimens were taken from 675, 203, and 110 patients at the admission (D1), 5th (D5), and 8th (D8) days of ICU stay, respectively. The patient’s demographic and clinical data were collected. Candida isolates were identified by conventional culture-based microbiology combined with molecular approaches. Overall, colonization was 184/675 (27.3%), 87/203 (42.8%), and 58/110 (52.7%) on D1, D5, and D8, respectively. Candida colonization dynamics were significantly associated with ICU type (odds ratio (OR) = 2.03, 95% CI 1.22–3.39, p = 0.007), respiratory infection (OR = 1.74, 95% CI 1.17–2.58, p = 0.006), hemodialysis (OR = 2.19, 95% CI 1.17–4.10, p = 0.014), COVID-19 (OR = 0.37, 95% CI 0.14–0.99, p = 0.048), and with a poor 3-month outcome (p = 0.008). Skin Candida spp. colonization can be an early warning tool to generate valuable insights into the epidemiology, risk factors, and survival rates of critically ill patients, and should be considered for epidemiological surveillance.
Descrição
Palavras-chave
Candida spp. intensive care unit colonization surveillance risk factors prevalence
Contexto Educativo
Citação
Nascimento T, Inácio J, Guerreiro D, Patrício P, Proença L, Toscano C, Diaz P, Barroso H. Insights into Candida Colonization in Intensive Care Unit Patients: A Prospective Multicenter Study. Journal of Fungi. 2024; 10(6):378. https://doi.org/10.3390/jof10060378
Editora
MDPI