CI - Saúde - CUF
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O Repositório Institucional da CUF foi constituído com o objectivo de armazenar, centralizar, divulgar e dar acesso à produção científica dos Hospitais e Clínicas CUF, em formato digital.
A CUF desenvolve a sua atividade de forma integrada e abrangente, aliando uma rede de hospitais e clínicas, ferramentas digitais e novas formas de prestação de cuidados de proximidade, estando, desta forma, onde, quando e como o cliente necessita. A missão da CUF é promover a prestação de serviços de saúde com os mais elevados níveis de qualidade e conhecimento, respeitando o primado da vida e o ambiente, através do desenvolvimento do capital intelectual das organizações, numa permanente vontade de ser e fazer melhor.
Na vanguarda da inovação terapêutica e tecnológica, a CUF, em estreita articulação com um corpo clínico reconhecidamente de excelência, promove uma cultura contínua de atualização do conhecimento científico. A entidade responsável pela formação, ensino e investigação em toda a rede é o CUF Academic Center. Através da promoção e incentivo à inovação, investigação clínica, desenvolvimento de competências, treino e simulação clínica e ensino das melhores práticas em saúde, o CUF Academic Center afirma-se atualmente como um centro de referência na área da saúde.
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- Anomalia Congénita Coclear: Tentativa de Relação Embriológica e Anátomo-FuncionalPublication . Maurício, JC; Biscoito, L; Branco, GIn this review of cochlear malformations, 17 cases were studied by CT scan (high resolution-target program) including 10 males and 7 females. The anomaly was bilateral in 12 cases and unilateral in 7 (the latter included 2 Mondini type aplasias and one Michel). The cochlear malformation (whose most frequent expression was the cochlear hypoplasia with 1 or 1 1/2 spires-65% of the cases) was associated to semicircular canals and/or vestibular aqueduct anomaly in 82% of the patients; it was exclusively of the anterior labyrinth in 18% of the cases. A middle ear malformation coexisted in 29%: in 3 cases with malleoincudal dysmorphy only and with tympanic aplasia in 2 others. These cochlear anomalies with CT expression were discussed considering the embryology, in view of a possible gestational dating, moreover relating to the hipocusia type: perceptive or combined.
- An alternative explanation of the origin of the signal in diffusion-weighted MRIPublication . Branco, GI formulated an alternative explanation for the origin of the signal in diffusion-weighted MRI (DWI) and tested it in a simple experimental model using gelatin. My findings indicate that the signal in DWI is influenced by the passage of water from the sol to the gel state, independently of the presence of cell structures or membrane-dependent diffusion.
- Montelukast in 2 atopic patients with intolerance to nonsteroidal anti-inflammatory drugs and paracetamol: 5-year follow-upPublication . Morais-Almeida, M; Marinho, S; Gaspar, A
- Patologia naso-sinusalPublication . Paço, J; Branco, C; Ruah, C; Marco, E; Barros, E; Ruah, S; Loureiro, C; Caroça, C; Almeida, E; Branco, G; Cardoso, S; Vilhena de Mendonça, F
- Periodontal impact of surgically induced dental lesions in mandibular osteodistraction: an animal study.Publication . Soares Correia, PE; Wehrbein, H; Mommaerts, MYAIM: The objective of the study was to evaluate the impact of dental lesions on the periodontium, in a canine model of mandibular osteodistraction. MATERIAL AND METHODS: In six adult male Beagle dogs, an osteotomy was made between the right second lateral incisor and canine, and a distraction device placed. The roots adjacent to the osteotomy were deliberately damaged by the reciprocating saw and chisel, with preservation of the attached gingiva. The osteodistraction protocol used was: latency of 7 days, rate of distraction 1mm per day, and rhythm once a day for 5 days. Vital staining was carried out with tetracycline, Xylenol Orange and Calcein Green. The dogs were sacrificed after 12 weeks of consolidation and the specimens were evaluated with light microscopy (native, polarized light, fluorescence, and after toluidin blue staining). RESULTS: The periodontal ligament (PDL) regeneration was observed in the 2500 slices examined. Cementum and dentine lesions were repaired by cellular cementum. Loose dentine and cementum-dentine fragments were embedded in regenerated PDL and their surface repaired by cementum. By means of light microscopic examination and within the limited observation time, no degenerative pulpal changes were found, when the pulp canal was not entered. Extensive pulp exposure and destruction resulted in ingrowth of the PDL and bone-like tissue. In that case, cellular cementum also lined the dentine surface of the pulp canal. CONCLUSION: Although there was an extensive reparative response to the para-pulpal lesions, none of the changes observed showed evidence of a loss of functional integrity of the periodontium at the distraction site. The fate of the tooth with exposed pulp canal remains uncertain.
- Enterocolic phlebitis" mimicking a primary tumor of the cecum--a rare presentation of an unusual entity.Publication . Cruz, J; Almeida, M; Soares, JIntestinal vasculitis is an infrequent entity in the absence of systemic vasculitis or chronic inflammatory bowel disease. The primary involvement of gut restricted to mesenteric venous territory is exceedingly rare. We report a pseudotumoural lesion of the cecum caused by localized phlebitis and venulitis associated with thrombosis, with a putative immune etiology, in a young adult presenting with obstructive intestinal crisis.
- Cutaneous mastocytosis: Two pediatric cases treated with topical pimecrolimus.Publication . Correia, O; Duarte, AF; Quirino, P; Azevedo, R; Delgado, LCutaneous mastocytosis is characterized by increased numbers of skin mast cells that release mediators causing pruritus, urticaria, and flushing. Most pediatric mastocytosis patients exhibit the pattern of urticaria pigmentosa, which typically appears during the first two years of life and resolves spontaneously in late adolescence. However, while the disease is active, patients are frequently symptomatic and uncomfortable, which justifies symptomatic treatment. We report 2 patients, a 14-month-old girl and a 26-month-old boy, with localized cutaneous erythematous lesions with a positive Darier sign. In each, a punch biopsy confirmed the diagnosis of mastocytosis. Treatment was instituted with pimecrolimus cream twice a day and oral antihistamine. An almost complete response was achieved after 4 months of therapy in both patients, with no clinical evidence of recurrence after 4 years and 2 years of follow-up, respectively. In children, the treatment of mastocytosis is directed primarily to avoiding potential mast cell degranulating agents and alleviating symptoms. Topical calcineurin inhibitors act by inhibiting T-cell activation and cytokine release; they may suppress mast cell- mediated reactions by reducing their degranulation. These two cases suggest that in localized cutaneous mastocytosis they are a safe and efficacious alternative to topical steroid therapy.
- Evaluating Residual Activity in 18F-FDG administrationPublication . Santos, A; Geão, A; Dias, L; Mota, A; Fernandes, MThe Positron Emission Tomography (PET) is an imaging technique, based on functional, biochemical and molecular information. It is also a useful tool in oncological examination. 18F-FluoroDeoxyGlucose (FDG) is a radiopharmaceutical widely used in nuclear medicine departments with PET facilities. FDG’s corrects administration is very important in order to achieve good images and correct Standard Uptake Values (SUV). The aim of this study was to evaluate the residual activity, according to the method used in our department. Materials & Methods: Residual activities of the syringes used to administer FDG to 125 patients were measured and recorded, during one month. The intravenous administration was always performed by the same four nuclear medicine technologists. These technologists are trained in this procedure, according with the developed technique, based on the procedure guidelines for PET imaging. This technique consists in administering FDG in a catheter with a triple channel system (standard system with three-way tap to enable saline flush); the syringe is always filled to its maximum capacity (5cc) and rinsed once, including needle rinsing. Registered time in every procedure was calibrated, in order not to include bias. Results: according to the analysis of the registered data, less than 1% of the activity calculated and measured for each patient remained on the syringe. Conclusions: regarding the search for the best administration procedure, we conclude that the technique used in our department results in a very low residual activity, meaning that it is an accurate technique that leads to reliable SUV values.
- Rinosinusites na prática clínica: guia de diagnóstico e tratamentoPublication . Paço, J; Branco, C; Ruah, C; Caroça, C; Barros, E; Branco, G; Ruah, S; Vilhena de Mendonça, F
- Otites na prática clínica: guia de diagnóstico e tratamentoPublication . Paço, J; Branco, C; Caroça, C; Vieira de Almeida, J; Caçador, M; Vilhena de Mendonça, F