Percorrer por autor "Silva-dos-Santos, A"
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- Acute Psychosis as Major Clinical Presentation of Legionnaires’ DiseasePublication . Coentre, Ricardo; Silva-dos-Santos, A; Cotrim-Talina, MWe report a case of a 61-year-old woman who presented with acute psychosis as a major manifestation of Legionnaires’ disease in the absence of other neuropsychiatric symptoms. Clinical history revealed dry cough and nausea. Observation showed fever and auscultation crackles in the lower lobe of the right lung. Laboratory testing demonstrated elevated C-reactive protein and lung chest radiograph showed patchy peribronchial and right lower lobe consolidation. Soon after admission, she started producing purulent sputum. Epidemiological data suggested Legionella pneumophila as possible cause of the clinical picture that was confirmed by urinary antigen detection and polymerase chain reaction of the sputum. She was treated with levofloxacin 750 mg/day for 10 days with complete remission of pulmonary and psychiatric symptoms. She has not had further psychotic symptoms.
- Avoiding revolving door and homelessness: The need to improve care transition interventions in psychiatry and mental healthPublication . Bravo, J; Buta, FL; Talina, M; Silva-dos-Santos, A
- A Closed Loop Brain-machine Interface for Epilepsy Control Using Dorsal Column Electrical StimulationPublication . Pais-Vieira, M; Yadav, AP; Moreira, D; Guggenmos, D; Silva-dos-Santos, A; Lebedev, M; Nicolelis, MLAlthough electrical neurostimulation has been proposed as an alternative treatment for drug-resistant cases of epilepsy, current procedures such as deep brain stimulation, vagus, and trigeminal nerve stimulation are effective only in a fraction of the patients. Here we demonstrate a closed loop brain-machine interface that delivers electrical stimulation to the dorsal column (DCS) of the spinal cord to suppress epileptic seizures. Rats were implanted with cortical recording microelectrodes and spinal cord stimulating electrodes, and then injected with pentylenetetrazole to induce seizures. Seizures were detected in real time from cortical local field potentials, after which DCS was applied. This method decreased seizure episode frequency by 44% and seizure duration by 38%. We argue that the therapeutic effect of DCS is related to modulation of cortical theta waves, and propose that this closed-loop interface has the potential to become an effective and semi-invasive treatment for refractory epilepsy and other neurological disorders.
- Doença mental, homocisteína, risco cardiovascular e síndrome metabólicaPublication . Silva-dos-Santos, A
- Editorial: How does brain stimulation work? Neuroversion and other putative mechanisms of actionPublication . Kar, SK; Silva-dos-Santos, A; Lebedev, MA; Deng, ZD
- Initial medical work-up in first-episode psychosisPublication . Coentre, R; Silva-dos-Santos, A; Lopes, J; Gracias, MJ; Talina, M
- Patient care transition in psychiatry and mental health (Transição entre níveis de cuidados e a adesão do doente)Publication . Silva-dos-Santos, A; Talina, M
- Retrospective study on structural neuroimaging in first-episode psychosisPublication . Coentre, R; Silva-dos-Santos, A; Talina, MCBackground. No consensus between guidelines exists regarding neuroimaging in firstepisode psychosis. The purpose of this study is to assess anomalies found in structural neuroimaging exams (brain computed tomography (CT) and magnetic resonance imaging (MRI)) in the initial medical work-up of patients presenting first-episode psychosis. Methods. The study subjects were 32 patients aged 18–48 years (mean age: 29.6 years), consecutively admitted with first-episode psychosis diagnosis. Socio-demographic and clinical data and neuroimaging exams (CT and MRI) were retrospectively studied. Diagnostic assessments were made using the Operational Criteria Checklist +. Neuroimaging images (CT and MRI) and respective reports were analysed by an experienced consultant psychiatrist. Results. None of the patients had abnormalities in neuroimaging exams responsible for psychotic symptoms. Thirty-seven percent of patients had incidental brain findings not causally related to the psychosis (brain atrophy, arachnoid cyst, asymmetric lateral ventricles, dilated lateral ventricles, plagiocephaly and falx cerebri calcification). No further medical referral was needed for any of these patients. No significant differences regarding gender, age, diagnosis, duration of untreated psychosis, in-stay and cannabis use were found between patients who had neuroimaging abnormalities versus those without. Discussion. This study suggests that structural neuroimaging exams reveal scarce abnormalities in young patients with first-episode psychosis. Structural neuroimaging is especially useful in first-episode psychosis patients with neurological symptoms, atypical clinical picture and old age.
- Suicidality risk assessment in primary carePublication . Silva-dos-Santos, A; Rothes, I; Teixeira, A; Gusmão, R