Percorrer por autor "Pechirra, Pedro"
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- Epidemiology and genetic variability of respiratory syncytial virus in Portugal, 2014–2018Publication . Sáez-López, Emma; Cristóvão, Paula; Costa, Inês; Pechirra, Pedro; Conde, Patrícia; Guiomar, Raquel; Peres, Maria João; Viseu, Regina; Lopes, Paulo; Soares, Vânia; Vale, Fátima; Fonseca, Patrícia; Freitas, Ludivina; Alves, Jose; Pessanha, Maria Ana; Toscano, Cristina; Mota-Vieira, Luísa; Veloso, Rita Cabral; Côrte-Real, Rita; Branquinho, Paula; Pereira‑Vaz, João; Rodrigues, Fernando; Cunha, Mário; Martins, Luís; Mota, Paula; Couto, Ana Rita; J, Bruges Armas; Almeida, Sofia; Rodrigues, DéboraRespiratory syncytial virus (RSV) is associated with substantial morbidity and mortality since it is a predominant viral agent causing respiratory tract infections in infants, young children and the elderly. Considering the availability of the RSV vaccines in the coming years, molecular understanding in RSV is necessary.
- ESCALA DE MATURAÇÃO MACROSCÓPICA E MICROSCÓPICA DO VERDINHO (Micromesistius poutassou)Publication . Gonçalves, Patrícia; Costa, Ana M.; Ferreira, Ana Luísa; Resende, Adelaide; Carmo Nunes Silva,; Abreu, Paula; Pechirra, Pedro; Instituto Português do Mar e da Atmosfera, I.P.Blue whiting (Micromesistius poutassou) is a mesopelagic teleost, of the gadidae family and widely distributed along the Atlantic North and Mediterranean. On the Portuguese coast, the main spawning season for this species occurs between January and March. At IPMA, the biological sampling of blue whiting is carried out regularly, in samples from discards collected onboard commercial vessels, fishing landings (Peniche, Matosinhos e Vila Real de St. António) and from scientific research surveys. Regarding the reproductive cycle, the identification of the maturity stages is made macroscopically during biological sampling. The maturity stage key currently in use at IPMA and applied to blue whiting is of the one suggested by Godinho et al. (2001), which was developed only based on macroscopic observations and descriptions, without microscopic validation. This study aims to microscopically describe the morphology of the gonads throughout the reproductive cycle for blue whiting, to validate and intercalibrate the macroscopic identifications based on histology and also to propose a new macroscopic maturity stage key taking into account the microscopic and macroscopic characteristics of the different stages from the sexual development cycle. Keywords: Blue whiting, Micromesistius poutassou, histology, macroscopic identification, microscopic maturity scale, macroscopic maturity scale.
- Estimates of 2012/13 influenza vaccine effectiveness using the case test-negative control design with different influenza negative control groupsPublication . Nunes, Baltazar; Machado, Ausenda; Guiomar, Raquel; Pechirra, Pedro; Conde, Patrícia; Cristovão, Paula; Falcão, IsabelBackground: In recent years several reports of influenza vaccine effectiveness (VE) have been made early for public health decision. The majority of these studies use the case test-negative control design (TND),which has been showed to provide, under certain conditions, unbiased estimates of influenza VE. Nevertheless, discussions have been taken on the best influenza negative control group to use. The presentstudy aims to contribute to the knowledge on this field by comparing influenza VE estimates using three test-negative controls: all influenza negative, non-influenza respiratory virus and pan-negative.Methods: Incident ILI patients were prospectively selected and swabbed by a sample of general practitioners. Cases were ILI patients tested positive for influenza and controls ILI patients tested negative forinfluenza. The influenza negative control group was divided into non-influenza virus control group andpan-negative control group. Data were collected on vaccination status and confounding factors. InfluenzaVE was estimated as one minus the odds ratio of been vaccinated in cases versus controls adjusted for confounding effect by logistic regression.Results: Confounder adjusted influenza VE against medically attended laboratory-confirmed influenza was 68.4% (95% CI: 20.7–87.4%) using all influenza negatives controls, 82.1% (95% CI: 47.6–93.9%) usingnon-influenza controls and 49.4% (95% CI: −44.7% to 82.3%) using pan-negative controls.Conclusions: Influenza VE estimates differed according to the influenza negative control group used.These results are in accordance with the expected under the hypothesis of differential viral interference between influenza vaccinated and unvaccinated individuals. Given the wide importance of TND study further studies should be conducted in order to clarify the observed differences.