Browsing by Author "Moncada, Margarida"
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- Adansonia digitata L. (Baobab fruit) effect on postprandial glycemia in healthy adults : a randomized controlled trialPublication . Rita, Keyla; Bernardo, Maria Alexandra; Silva, Maria Leonor; Brito, José; Mesquita, Maria Fernanda; Pintão, Ana Maria; Moncada, MargaridaBaobab fruits have been traditionally used in Africa due to their therapeutic properties attributed to their high polyphenol content. The aim of the study was to investigate the effect of baobab fruit on postprandial glycaemia in healthy adults and to measure its bioactive compounds and antioxidant activity. The study (NCT05140629) was conducted on 31 healthy subjects. The participants were randomly allocated in the control group (oral glucose tolerance test (OGTT); n = 16) and in the intervention group (OGTT, followed by administration of 250 mL baobab aqueous extract (BAE); n = 15). Total phenols, proanthocyanins, hydrolyzable tannins, and antioxidant activity (FRAP, DPPH, ABTS, and inhibition of O2•− and NO• methods) were quantified. Repeated measures ANOVA of mixed type and independent samples t-test were used. Glycemia incremental area under the curve (p = 0.012) and glucose maximum concentration (p = 0.029) was significantly lower in the intervention group compared to the control group. The BAE revealed high total contents of phenols, proanthocyanins, and hydrolyzable tannins, as well as a strong capacity to scavenge superoxide anions and nitric oxide radicals and a high antioxidant activity. In conclusion, this study encourages the use of this food component as a promising source of natural antioxidants and a hypoglycemic agent under glucose load acute conditions.
- Adansonia digitata L. (Baobab) bioactive compounds, biological activities, and the potential effect on glycemia : a narrative reviewPublication . Silva, Maria Leonor; Rita, Keyla; Bernardo, Maria Alexandra; Mesquita, Maria Fernanda de; Pintão, Ana Maria; Moncada, MargaridaAdansonia digitata L. fruit, also known as baobab, has been used traditionally throughout the world for its medicinal properties. Ethnopharmacological uses of various plant parts have been reported for hydration, antipyretic, antiparasitic, antitussive, and sudorific properties and also in the treatment of diarrhea and dysentery in many African countries. Several studies have revealed that in addition to these applications, baobab has antioxidant, anti-inflammatory, analgesic, and antimicrobial activities. The health benefits of baobab have been attributed to its bioactive compounds, namely phenols, flavonoids, proanthocyanins, tannins, catechins, and carotenoids. Baobab fruit is also an important source of vitamin C and micronutrients, including zinc, potassium, magnesium, iron, calcium, and protein, which may reduce nutritional deficiencies. Despite scientific studies revealing that this fruit has a wide diversity of bioactive compounds with beneficial effects on health, there is a gap in the review of information about their mechanisms of action and critical analysis of clinical trials exploring, in particular, their effect on glycemia regulation. This work aims to present a current overview of the bioactive compounds, biological activities, and effects of A. digitata fruit on blood glucose, highlighting their potential mechanisms of action and effects on glycemia regulation, evaluated in recent animal and human trials.
- Efeitos benéficos para a saúde humana de framboesas produzidas em PortugalPublication . Câmara, Madalena Bettencourt da; Moncada, Margarida
- Effect of aqueous cinnamon extract on the postprandial glycemia levels in patients with type 2 Diabetes mellitus : a randomized controlled trialPublication . Rachid, Ana Paula; Moncada, Margarida; Mesquita, Maria Fernanda de; Brito, José; Bernardo, Maria Alexandra; Silva, Maria LeonorCinnamon is a spice used in traditional cuisine that has been investigated due to hypoglycemic properties. The objective of this study was to investigate the effect of aqueous cinnamon extract on postprandial glycemia levels in type 2 diabetes mellitus (DM2) adults. This clinical trial enrolled 36 adults with DM2, randomly allocated in two groups: the control group (n = 18) took only an oral glucose tolerance test (OGTT) and the intervention group (n = 18) took OGTT immediately followed by aqueous cinnamon extract (6 g/100 mL) ingestion. Blood glucose levels were measured on fasting and after 30, 60, 90 and 120 min in both groups. The chemical analysis of the aqueous cinnamon extract included total phenols content determination and antioxidant activity assessment through FRAP and DPPH methods. The data reveal that aqueous cinnamon extract ingestion did not show a significant difference in the incremental area under the curve (p = 0.834), maximum glucose concentration (p = 0.527) and glucose concentration variation (p = 0.873) compared with the control group. Cinnamon extract possess a total phenol content of 1554.9 mg/L gallic acid equivalent and a strong antioxidant capacity, revealed by the DPPH (5125.0 µmol Trolox/L) and FRAP (3658.8 µmol Trolox/L) tests. Aqueous cinnamon extract did not significantly influence postprandial glucose response in diabetic patients during an OGTT.
- Mediadores inflamatórios na saliva: associação entre obesidade e doença periodontalPublication . Cachinho, Ricardo; Manso, Ana Cristina; Bernardo, Alexandra; Moncada, Margarida; Mendes, José João; Mesquita, Maria Fernanda de
- Study of the Phenolic Content and the antioxidant capacity of Rubus idaeus L. genotypes within the development of a national cultivarPublication . Cornamusaz, Rita; Luz, Francisco; Oliveira, Pedro Brás de; Moncada, Margarida; Câmara, Madalena Bettencourt daThe production of raspberries in Portugal has increased considerably in the last two decades, assuming a great economic interest today. Here, we studied the phenolic content and the antioxidant capacity of selected genotypes within a breeding program. The results suggest that this program may be unintentionally selecting raspberry phenolics. If so, this would be of particular interest, since there is scientific evidence that raspberry phenolics or their metabolites may have beneficial health effects, namely antioxidant activity.