Percorrer por autor "Mendes, Lucas Alexandre de Sousa"
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- Is cold storage still a must? Evaluating room-temperature onabotulinumtoxinA for glabellar lines treatmentPublication . Rodriguez, Ruth Yimna Del Socorro Blanco; Canales, Giancarlo De La Torre; Giracca, César Nunes; Vaz, Thaís Caroline Schwartz Saldanha; Paulovski, Gislaine; Mendes, Lucas Alexandre de Sousa; Cordeiro, Jairo Matozinho; Murakami, Fábio Seigi; Câmara-Souza, Mariana BarbosaBackground: New botulinum toxin type A (BoNT-A) formulations eliminated cold-chain storage before reconstitution. Nonetheless, concerns remain about BoNT-A properties when stored at room temperature after reconstitution. Aim: This study aimed to evaluate the sterility and effectiveness of BoNT-A storage at room temperature in glabellar wrinkles. Methods: BoNT-A (Allergan Botox, Brazil) was reconstituted and maintained in a stove at 37°C for 60 days and then tested for sterility according to the Pharmacopeia guidelines. Then, sixty patients aged 25–60 years were divided into two groups: Group 1 (G1) received BoNT-A immediately after reconstitution, and Group 2 (G2) received BoNT-A after 7 days at room temperature. Participants were assessed for wrinkle severity using the Merz Scale, satisfaction with treatment using the Face-Q scale, and muscle activity by electromyography. Data were collected before injections and after 15, 30, 60, and 90 days. Results: Absence of turbidity evidenced no microbial growth in all periods analyzed. Both groups showed significant reductions in glabellar contraction (p < 0.001), wrinkle severity (p < 0.05), and improved satisfaction. G1 presented lower wrinkle severity, while G2 reported higher satisfaction (p < 0.05). Conclusion: Room temperature and longer storage periods may not affect OnabotulinumtoxinA sterility and clinical results.
- Rheological and structural analysis of hyaluronic acid fillers used for chin augmentationPublication . Carbone, Ana Claudia; Neves, Maria Luiza Boechat Borges; Zinco, André Gaspar; Nayak, Vasudev Vivekanand; Mendes, Lucas Alexandre de Sousa; Assad, Andressa De Marchi El; Câmara-Souza, Mariana Barbosa; Teixeira, Stephanie; Machado Filho, Daniel Augusto; Murakami, Fabio Seigi; Canales, Giancarlo De la TorreIntroduction: Chin contouring and projection represent some of the most frequently requested procedures in aesthetic practice using hyaluronic acid (HA) fillers. Variations in the physicochemical and viscoelastic properties of HA fillers may directly influence clinical performance. This study aimed to compare four commercially available HA gels specifically indicated for chin projection: JUVÉDERM® VOLUX, RESTYLANE® LYFT, PERFECTHA® SUBSKIN, and RESTYLANE® SHAYPE. Methods: The samples were characterized using scanning electron microscopy, dynamic light scattering, zeta potential, and swelling factor (SF). Rheological assessments included frequency sweep, amplitude sweep, and cohesivity modulus (MOC). All tests were performed in triplicate. Results: JUVÉDERM® VOLUX exhibited the highest SF values (3.28–3.37), indicating greater swelling capacity, whereas RESTYLANE® LYFT showed the lowest (1.53–1.66), reflecting a denser and less expansive profile. Rheological analysis revealed that RESTYLANE® LYFT and RESTYLANE® SHAYPE had higher storage modulus (G′) values at elevated frequencies. MOC was significantly higher for RESTYLANE® SHAYPE and PERFECTHA® SUBSKIN compared with JUVÉDERM® VOLUX, suggesting greater resistance to deformation. Conclusions: Overall, RESTYLANE® SHAYPE demonstrated the most favorable balance, combining moderate SF, high G′ values, and elevated MOC. However, patient-specific anatomy, aesthetic goals, and injector expertise remain critical in determining the most appropriate product for chin contouring.