Browsing by Author "Freitas, C."
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- Age-related expression of TGF beta family receptors in human cumulus oophorus cellsPublication . Ribeiro, A.; Freitas, C.; Matos, L.; Gouveia, A.; Gomes, F.; Silva Carvalho, J. L.; Almeida, H.During ovarian follicle growth, local cellular interactions are essential for oocyte quality acquisition and successful fertilization. While cumulus cells (CCs) nurture oocytes, they also deliver oocyte-secreted factors (OSFs) that activate receptors on CCs. We hypothesized that disturbance of those interactions contributes to age-related lower reproductive success in women submitted to assisted reproductive technology treatments.
- Finding Out The Neurological Consequences Of Covid-19Publication . Alves, A.I.; Freitas, C.; Viveiros, A.; Ribeiro, L.; Faria, S.; Freitas, D.; Faria, R.; Faria, J.t- Introduction: Since the first official case of COVID-19 in China in December 2019, researchers have been trying to uncover the mechanism of action of the severe acute respiratory syndrome Coronavirus 2 (Sars-CoV-2), which attacks several organs in addition to the lungs and causes circulatory changes that can lead to death not only from lung failure but also due to commitment of other organs. Objective: The aim of this study is to find out the neurological consequences of COVID-19. Material and methods: A systematic review of the literature was concretised by mobilizing the descriptors: "Sars-Cov-2", "coronavirus infections" and "Neurological Consequences". Databases were selected and seven articles were included for analysis. Results and discussion: Although the effects of Sars-CoV-2 on the lung are exemplary and frightening, the long-term effects on the nervous system may be greater and even more overwhelming, as the regeneration of nerve tissue is difficult and can lead to general disability, as the nervous system coordinates the functions of the entire body. All studies show the presence of any kind of injury (mild or severe) to Central Nervous System, but some of them highlight the need for further studies to have great certainty. Conclusion: It can be said that the studies all agree on the possibility of existing neurological sequelae and a majority agree on the need for other studies.
- Gestão do tempo dos enfermeiros gestores numa ULS – estudo de caso,Publication . Freitas, C.; Martins, MM
- Gestão em enfermagem numa ULS – estudo de casoPublication . Freitas, C.; Martins, MM
- Reclassification of the intermediate group classified according to heartscore taking in considertaion individual genetic predisposition to coronary artery diseasePublication . Mendonça, M.; Pereira, A.; Rodrigues, R.; Neto, M.; Sousa, A.C.; Freitas, S.; Freitas, C.; Freitas, A.I.; Borges, S.; Palma dos Reis, R.Introduction: Cardiovascular risk stratification has included traditional cardiovascular risk factors (TRF) including tobacco, cholesterol and blood pressure adjusted to age and sex. The utility of genetic risk scores (GRS) as predictors of cardiovascular risk remains inconclusive. Objective: We intended to evaluate the ability of a multilocus GRS within the intermediate risk subgroup, defined by the European Heart score, to add predictive power for the association with coronary artery arterial disease (CAD). Methods: After applying European SCORE (ES) stratification to a total population of 2703 Portuguese individuals, 639 individuals with 59.0 ± 4.3 years were considered to be at intermediate risk subgroup (2 Results: GRS was an independent predictor for CAD (OR=2.411; p<0.0001). Diabetes mellitus (OR=3.196;p<0.0001), arterial hypertension (OR=2.201; p=0.003) and smoking (OR=3.148; p<0.0001) were also significantly associated with CAD. AUC increased from 0.694 to 0.734 after adding GRS to TRF. When discriminated by tertiles of GRS, the AUC for TRF was maximum for the 2nd tertile GRS [AUC (TRF)=0.734] and lower for the 1st and 3rd tertiles (AUC =0.673 and AUC =0.671, respectively). NRI showed better increase in the intermediate risk subgroup with a 35.2% interpreted as the roportion of patients reclassified to a more appropriate risk category, and 29.4% on the lower risk. Conclusion: In our population, the GRS increased the predictive value of TRF in the subgroup of patients at intermediate risk by the European Score. The predictive value of TRF is lower in patients with higher GRS. In this subgroup, the inclusion of genotyping may be considered for better stratification of cardiovascular risk.
- The Efficacy of LUCAS in Cardiac ArrestPublication . Alves, A.I.; Freitas, C.; Viveiros, A.; Ribeiro, L.; Veríssimo, M.; Fernandes, O.Introduction: Chest compression is the basic technique of cardiopulmonary resuscitation (CPR) in patients with cardiac arrest. The quality and early performance of CPR is critical to improve the prognosis and chances of restoring spontaneous blood flow. Today we have manual compressions and mechanical chest compression devices. Objective: The aim of this study is to clarify the importance of the LUCAS system (The Lund University Cardiac Arrest System) in CPR. Material and methods: A systematic review of the literature by mobilizing the descriptors "Cardiac Arrest", "Lucas Efficacy" and "nursing", using the methodological head. Ten conceivable databases were selected, between 2010-2020, and seven articles were included for analysis. Results and discussion: The results of the studies are different, as four of the studies indicate that LUCAS is fully effective, particularly in fatigue and transport, but two of them do not recognise its full effectiveness. One of the studies mentions that the fact that compression by the automatic device is effective does not necessarily reflect a better result. The vast majority of the studies recognise the need for further studies to make more convincing decisions. Conclusion: Mechanical chest compression devices can improve patient outcome if used appropriately in the event of cardiac arrest. The hemodynamic performance of the LUCAS compression-decompression system is, according to some results, better than manual CPR. However, the quality of the current evidence is not sufficient. Randomised studies are needed to evaluate the effect of mechanical chest compression devices on survival inside or outsider the hospital.