Age-related expression of TGF beta family receptors in human cumulus oophorus cells

Ribeiro, A.; Freitas, C.; Matos, L.; Gouveia, A.; Gomes, F.; Silva Carvalho, J. L.; Almeida, H.

http://hdl.handle.net/10400.26/33005

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Authors

Silva Carvalho, J. L.

Almeida, H.

Abstract(s)

During ovarian follicle growth, local cellular interactions are essential for oocyte quality acquisition and successful fertilization. While cumulus cells (CCs) nurture oocytes, they also deliver oocyte-secreted factors (OSFs) that activate receptors on CCs. We hypothesized that disturbance of those interactions contributes to age-related lower reproductive success in women submitted to assisted reproductive technology treatments.

Keywords

Adult Anaplastic Lymphoma Kinase Bone Morphogenetic Protein Receptors, Type I Bone Morphogenetic Protein Receptors, Type II Cumulus Cells Female Fertilization in Vitro Gene Expression Regulation, Developmental Humans Middle Aged Oocytes Ovarian Follicle Protein-Serine-Threonine Kinases Receptor Protein-Tyrosine Kinases Receptor, Transforming Growth Factor-beta Type I Receptors, Transforming Growth Factor beta Reproductive Techniques, Assisted Portugal

URI

http://hdl.handle.net/10400.26/33005

Citation

Ribeiro, A., Freitas, C., Matos, L. et al. Age-related expression f TGF beta family receptors in human cumulus oophorus cells. J Assist Reprod Genet 34, 1121–1129 (2017).