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Publicação
Age-related expression of TGF beta family receptors in human cumulus oophorus cells
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Orientador(es)
Resumo(s)
During ovarian follicle growth, local cellular interactions are essential for oocyte quality acquisition and successful fertilization. While cumulus cells (CCs) nurture oocytes, they also deliver oocyte-secreted factors (OSFs) that activate receptors on CCs. We hypothesized that disturbance of those interactions contributes to age-related lower reproductive success in women submitted to assisted reproductive technology treatments.
Descrição
Palavras-chave
Adult Anaplastic Lymphoma Kinase Bone Morphogenetic Protein Receptors, Type I Bone Morphogenetic Protein Receptors, Type II Cumulus Cells Female Fertilization in Vitro Gene Expression Regulation, Developmental Humans Middle Aged Oocytes Ovarian Follicle Protein-Serine-Threonine Kinases Receptor Protein-Tyrosine Kinases Receptor, Transforming Growth Factor-beta Type I Receptors, Transforming Growth Factor beta Reproductive Techniques, Assisted Portugal
Contexto Educativo
Citação
Ribeiro, A., Freitas, C., Matos, L. et al. Age-related expression f TGF beta family receptors in human cumulus oophorus cells. J Assist Reprod Genet 34, 1121–1129 (2017).
Editora
Springer