Browsing by Author "Fernandes, Ana Isabel"
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- 4Ps - perceções, preferências e prescrição personalizadaPublication . Nogueira, Sofia; Fernandes, Ana Isabel
- About the effect of eye blinking on drug release from pHEMA-based hydrogels: an in vitro studyPublication . Galante, Raquel; Paradiso, Patrizia; Moutinho, Maria Guilhermina; Fernandes, Ana Isabel; Mata, José; Matos, António; Colaço, Rogério; Saramago, Benilde; Serro, Ana Paula"The development of new ophthalmic drug delivery systems capable of increasing the residence time of drugs in the eye and improve its bioavailability relatively to eyedrops has been object of intense research in recent years. Several studies have shown that drug loaded therapeutic soft contact lenses (SCLs) constitute a promising approach, with several potential advantages as compared with collyria. The main objective of this work is to study the effect of repetitive load and friction cycles caused by the eye blinking, on the drug release from hydrogels used in SCLs which, as far as we know, was never investigated before. Two poly-2-hydroxyethylmethacrylate based hydrogels, pHEMA-T and pHEMA-UV, were used as model materials. Levofloxaxin was chosen as model drug. The hydrogels were fully characterized in what concerns structural and physicochemical properties. PHEMA-UV revealed some superficial porosity and a lower short range order than PHEMA-T. We observe that the load and friction cycles enhanced the drug release from pHEMAUV hydrogels. The application of a simple mathematical model, which takes into account the drug dilution caused by the tear flow, showed that the enhancement of the drug release caused by blinking on this hydrogel may be relevant in in vivo conditions. Conversely, the more sustained drug release from pHEMA-T is not affected by load and friction cycles. The conclusion is that, depending on the physicochemical and microstructural characteristics of the hydrogels, blinking is a factor that may affect the amount of drug delivered to the eye by SCLs and should thus be considered."
- Addressing drug solubility problems : a case-studyPublication . Costa, Nuno F. da; Fernandes, Ana Isabel; Pinto, João F.
- Bridging generations through integrative learning, research, and community care : The ESPIEM ProjectPublication . Auxtero, Maria Deolinda; Costa, Isabel Margarida; Brito, José; Figueiredo, Alexandra; Ascenso, Carla; Miranda, Margarida; Caneiras, Cátia; Fernandes, Ana IsabelCommunication abstract presented at the EAFP Annual Conference 2025 – “Pharmaceutical Education & Research: SWOT Analysis”. Faculty of Pharmacy, University of Coimbra, 13th-15th of May 2025
- Co-amorphization of olanzapine for solubility enhancementPublication . Costa, Nuno F. da; Fernandes, Ana Isabel; Pinto, João F. Pinto
- Coffee in the workplace: a social break or a performance enhancer?Publication . Rodrigues, Carla F.; Raposo, Hélder; Pegado, Elsa; Fernandes, Ana IsabelCoffee is a socially rooted drink with pharmacological properties. It is embedded in different everyday rituals, including ‘coffee breaks’ during working hours. This paper analyzes the role of coffee at workplace. Focusing on three professional areas associated with high pressure and responsive demands, we explore the social expression of coffee use at work, and how it is mobilized as a tool for managing sleepiness, fatigue, stress, and concentration problems, amongst other work-related issues.
- Cohesiveness of powdered co-amorphous Olanzapine and impact on tablet productionPublication . Costa, Nuno F. da; Pinto, João F.; Fernandes, Ana IsabelThe evaluation of the processability of co-amorphous mixtures is of paramount importance since these systems are increasingly used to address the poor solubility presented by most of the drugs in research and development. This work shows that co-amorphous olanzapine powders present higher cohesiveness than their crystalline counterpart and resulted in the production of tablets with a higher tensile strength and a slower release of the drug. As a result, this work demonstrates that despite the solubility advantages of co-amorphous mixtures, consideration should be given to the downstream processing of formulations containing such materials.
- Compliance aids in elderly medication packaging: comparative study of Portugal and FrancePublication . Fernandes, Ana Isabel; Henriques Dias Fernandes, Ana Isabel; Brito, José; Almeida de Brito, José Américo; Auxtero, Maria DeolindaPoster apresentado no Congresso Nacional dos Farmacêuticos 2024. Lisboa, 21-23 Novembro 2024
- Dispensing of food supplements in the treatment and prevention of urinary tract infectionsPublication . Setoca, Beatriz; Fernandes, Ana IsabelUrinary tract infections constitute an important public health issue due to recurrence and antibiotic resistance. Currently, antibiotics are the standard therapy but non-antibiotic approaches, such as food supplements, could be beneficial and reduce bacterial resistance. This work aimed at a better understanding of the perception of health professionals involved in dispensing and counselling, in the community pharmacy, regarding the utility of these products as preventive alternatives and therapeutic approaches.
- Drug-excipient and drug-drug mixtures : a pathway for the production of co-amorphous entitiesPublication . Costa, Nuno F. da; Fernandes, Ana Isabel; Pinto, João F.
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