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Advisor(s)
Abstract(s)
The evaluation of the processability of co-amorphous mixtures is of paramount importance since these systems are increasingly used to address the poor solubility presented by most of the drugs in research and development. This work shows that co-amorphous olanzapine powders present higher cohesiveness than their crystalline counterpart and resulted in the production of tablets with a higher tensile strength and a slower release of the drug. As a result, this work demonstrates that despite the solubility advantages of co-amorphous mixtures, consideration should be given to the downstream processing of formulations containing such materials.
Description
Communication abstract: Proceedings of the 5th International Congress of CiiEM - Reducing inequalities in Health and Society, held at Egas Moniz’ University Campus in Monte de Caparica, Almada, from June 16th to 18th, 2021.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords
Co-amorphous Cohesiveness Dissolution Olanzapine Tablets Tensile strength
Citation
da Costa NF, Pinto JF, Fernandes AI. Cohesiveness of Powdered Co-Amorphous Olanzapine and Impact on Tablet Production. Medical Sciences Forum. 2021; 5(1):2. https://doi.org/10.3390/msf2021005002
Publisher
MDPI