Percorrer por autor "Fernandes, Ana I."
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- Additive manufacturing (3D printing): a new approach for the manufacture of individualized medicinesPublication . Figueiredo, Sara; Brízio, Ana; Carvalho, Fátima G.; Fernandes, Ana I.; Pinto, João F.
- Addressing drug solubility problems : a case-studyPublication . Costa, Nuno F. da; Fernandes, Ana I.; Pinto, João F.
- Amorphous and co-amorphous Olanzapine stability in formulations intended for wet granulation and pelletizationPublication . Costa, Nuno F. da; Daniels, Rolf; Fernandes, Ana I.; Pinto, João F.The preparation of amorphous and co-amorphous systems (CAMs) effectively addresses the solubility and bioavailability issues of poorly water-soluble chemical entities. However, stress conditions imposed during common pharmaceutical processing (e.g., tableting) may cause the recrystallization of the systems, warranting close stability monitoring throughout production. This work aimed at assessing the water and heat stability of amorphous olanzapine (OLZ) and OLZ-CAMs when subject to wet granulation and pelletization. Starting materials and products were characterized using calorimetry, diffractometry and spectroscopy, and their performance behavior was evaluated by dissolution testing. The results indicated that amorphous OLZ was reconverted back to a crystalline state after exposure to water and heat; conversely, OLZ-CAMs stabilized with saccharin (SAC), a sulfonic acid, did not show any significant loss of the amorphous content, confirming the higher stability of OLZ in the CAM. Besides resistance under the processing conditions of the dosage forms considered, OLZ-CAMs presented a higher solubility and dissolution rate than the respective crystalline counterpart. Furthermore, in situ co-amorphization of OLZ and SAC during granule production with high fractions of water unveils the possibility of reducing production steps and associated costs.
- Assessment of the stability of co-amorphous Olanzapine in tabletsPublication . Costa, Nuno F. da; Pinto, João F.; Fernandes, Ana I.
- Assessment of the stability of co-amorphous Olanzapine in tabletsPublication . Costa, Nuno F. da; Pinto, João F.; Fernandes, Ana I.
- Association between culture and the preference for, and perceptions of, 11 routes of medicine administration : a survey in 21 countries and regionsPublication . Murdan, Sudaxshina; Wei, Li; Riet-Nales, Diana A. van; Gurmu, Abyot Endale; Usifoh, Stella Folajole; Tăerel, Adriana-Elena; Yıldız-Peköz, Ayca; Krajnović, Dušanka; Azzopardi, Lilian M.; Brock, Tina; Fernandes, Ana I.; Santos, André Luis Souza dos; Anto, Berko Panyin; Vallet, Thibault; Lee, Eunkyung Euni; Jeong, Kyeong Hye; Akel, Marwan; Tam, Eliza; Volmer, Daisy; Douss, Tawfik; Shukla, Sharvari; Yamamura, Shigeo; Lou, Xiaoe; Riet, Bauke H.G. van; Usifoh, Cyril O.; Duwiejua, Mahama; Ruiz, Fabrice; Furnham, AdrianMedicines can be taken by various routes of administration. These can impact the effects and perceptions of medicines. The literature about individuals' preferences for and perceptions of the different routes of administration is sparse, but indicates a potential influence of culture. Our aim was to determine: (i) any association between one's culture and one's preferred route of medicine administration and (ii) individual perceptions of pain, efficacy, speed of action and acceptability when medicines are swallowed or placed in the mouth, under the tongue, in the nose, eye, ear, lungs, rectum, vagina, on the skin, or areinjected. A cross-sectional, questionnaire-based survey of adults was conducted in 21 countries and regions of the world, namely, Tunisia, Ghana, Nigeria, Turkey, Ethiopia, Lebanon, Malta, Brazil, Great Britain, United States, India, Serbia, Romania, Portugal, France, Netherlands, Japan, South Korea, Hong Kong, mainland China and Estonia, using the Inglehart–Welzel cultural map to ensure coverage across all cultures. Participants scored the pain/discomfort, efficacy, speed of onset and acceptability of the different routes of medicine administration and stated their preferred route. Demographic information was collected. A total of 4435 participants took part in the survey. Overall, the oral route was the most preferred route, followed by injection, while the rectal route was the least preferred. While the oral route was the most preferred in all cultures, the percentage of participants selecting this route varied, from 98% in Protestant Europe to 50% in the African-Islamic culture. A multinomial logistic regression model revealed a number of predictors for the preferred route. Injections were favoured in the Baltic, South Asia, Latin America and African-Islamic cultures while dermal administration was favoured in Catholic Europe, Baltic and Latin America cultures. A marked association was found between culture and the preference for, and perceptions of the different routes by which medicines are taken. This applied to even the least favoured routes (vaginal and rectal). Only women were asked about the vaginal route, and our data shows that the vaginal route was slightly more popular than the rectal one.
- Characterization and stability of co-amorphous systems containing Olanzapine and sulfonic acidsPublication . Santos, Inês A.; Bastos, Ana C.; Pinto, João F.; Fernandes, Ana I.
- Co-formability, solubility enhancement and stability of Olanzapine co-amorphous systems produced with different co-formersPublication . Bastos, Ana C.; Santos, Inês A.; Pinto, João F.; Fernandes, Ana I.
- Co-formability, solubility enhancement and stability of Olanzapine co-amorphous systems produced with different co-formersPublication . Bastos, Ana C.; Santos, Inês A.; Pinto, João F.; Fernandes, Ana I.
- Comparison of the amorphization ability of two polymorphic forms of OlanzapinePublication . Chendo, Catarina; Costa, Nuno F.; Pinto, João F.; Fernandes, Ana I.