Browsing by Author "Costa, F. A."
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- Dose Administration Aid system in the elderly: testing student active participation in the implementation of a new service for community pharmacyPublication . Costa, F. A.; Miranda, I.; Cavaco-Silva, P.; Oliveira, P.; Carneiro, C.; Fernandes, A. I.
- Evaluation of influenza vaccination services in a community pharmacy in Lisbon, PortugalPublication . Aguiar, J. P.; Matias, B.; Cavaco-Silva, P.; Costa, F. A.
- Identification of drug related problems in a sample of Portuguese nursing homesPublication . Silvestre, L.; Cavaco-Silva, P.; Oliveira, P.; Carneiro, C.; Fernandes, A. I.; Costa, F. A.
- Medicines review in the elderlyPublication . Costa, F. A.; Miranda, I.; Periquito, C.; Silvestre, L.; Cavaco Silva, P.; Fernandes, A. I.; Carneiro, C.; Taveira, N.
- Portuguese pharmacists perceived needs of education in anticoagulationPublication . Caldeira, A.; Papastergiou, J.; Kheir, N.; Rydant, S.; Antoniou, S.; Costa, F. A.; International Pharmacists for Anticoagulation Care Taskforce
- Potentially inappropriate medication in nursing homes: application of the Beers criteriaPublication . Periquito, C.; Cavaco-Silva, P.; Oliveira, P.; Carneiro, C.; Fernandes, A. I.; Costa, F. A.
- Revisão e reconciliação terapêutica em hospitalização domiciliáriaPublication . Brito, A.; Simões, A.; Costa, F. A.; Alcobia, A.
- The cancer registry as an ally in monitoring treatment effectivenessPublication . Costa, F. A.; Ramos, C.; Murteira, R.; Almodovar, T.; Passos-Coelho, J. L.; Carvalho, M. I.; Costa, L.; Brito, M. J.; Ramos, S.; Ferreira, M.; Miranda, A. C.OBJECTIVE: To evaluate if the cancer registry database can be used to monitor treatment effectiveness using nivolumab treatment of non-small cell lung cancer (NSCLC) as an example. METHOD: An observational inception cohort was used, where all registered cases of NSCLC with authorisation to initiate treatment with nivolumab were monitored retrospectively to evaluate disease characteristics and response to prior treatments. Current exposure to nivolumab was prospectively characterised and treatment outcomes classified based on the clinical information registered in the patient medical record. The main outcome measure used to assess treatment effectiveness was overall survival (OS). Secondary outcomes considered were progression free survival (PFS) as a measure of effectiveness and occurrence of Adverse Drug Reaction (ADRs) as a measure of safety. Data were analysed using SPSS, version 24. RESULTS: A total of 115 patients received treatment with nivolumab for NSCLC, between November 1st 2015 and July 31st 2016, and were registered in the database. The majority were non-squamous type (n=107). The median OS was 11.4 months {CI95%: 11.1-11.7}, with a 1-year survival of 44%, in line with clinical trial data. Median PFS was 5.4 months {CI95%: 2.8-7.9}. Treatment was discontinued in 82 cases, most frequently due to disease progression. There were 38 cases of ADRs documented in the patient medical chart, 21 of which led to treatment discontinuation. CONCLUSION: The analysed data suggest that the cancer registry is a powerful tool to monitor treatment effectiveness, although considerable investment is needed to improve the medical culture of recording treatment exposure, particularly documentation of ADRs.